| 1. | Radiation Safety | Luz Cheng | ||
| 1.1 | Review of basic radiation safety | |||
| 1.2 | Specifics of radiation safety with enclosed sources (GNL and Shope Lab irradiators | |||
| 1.3 | TDSHS Requirements for Security of Radioactive Materials of Concern | |||
| 2. | Introduction to radiation biology | Joan Nichols | ||
| 2.1 | Use of irradiation to inactivate biological materials | |||
| 2.2 | Mechanism of ioizing raditation invactivation | |||
| 2.2.1 | Effect of target size on dosage required | |||
| 2.2.2 | Effect of target matrix on effect of radiation | |||
| 2.2.3 | Why kill curves are necessary | |||
| 3. | Biological Safety in using gamma irradiation | Dee Zimmermann | ||
| 3.1 | Precautions to ensure biological safety in packaging | |||
| 3.2 | Transport and storage of material to irraditor | |||
| 3.3 | Ensuring inactivation (generation of kill curves) | Tom Ksiazek | ||
| 3.4 | SOP — kill curve | |||
| 3.5 | Example — machine output | |||
| 3.6 | Publication — Lassa / Ebola / Marburg examples of kill curves | |||
| 3.7 | Calculating expposure times or use of provided tables | |||
| 3.8 | Documenting inactivation | |||
| 4. | Break | |||
| 5. | Security | Dee Zimmermann | ||
| 5.1 | Select Agent Security | |||
| 5.1.1 | Precautions to insure security of removal from high containment labs | |||
| 5.1.2 | Precautions required in transfer of materials from Lab to irradiator or storage area | |||
| 5.1.3 | Documenting removal and inactivation of the material for security purposes | |||
| 6. | Practical familiarization with the Devices | Colette Pietzsch (Keng) and Terry Juelich | ||
| 6.1 | Introduction to the mechanical aspects | |||
| 6.2 | Practical Demonstration of operation | |||
| 6.2.1 | Placing materials | |||
| 6.2.2 | Setting the Timing Mechanism on the Devices | |||
| 6.2.3 | Interruption of the exposure cycle for refreshing coolant | |||
| 6.2.4 | Termination of Run and Labeling of materials | |||