Larry Denner, Ph.D.
Larry Denner, Ph.D.
Division of Endocrinology and Metabolism
Department of Internal Medicine
University of Texas Medical Branch
8.138 Medical Research Building
Galveston, TX 77555-1060
Larry's work encompasses a broad approach to improving human health. This includes identification of novel therapeutic targets for small molecule drug discovery, development of new stem cell-based therapies, assessment of the mechanism of action of existing therapies in order to improve efficacy and side-effects, and the discovery, testing, and implementation of new biomarkers for diagnosis and management of human diseases. These diseases currently include Alzheimer's disease, traumatic brain injury, substance abuse, infertility in women, diabetes, obesity, metabolic syndrome, and ovarian, prostate, and hepatocellular carcinoma. His research uses cell-free systems, cell models, animal models, and patients. He focuses on signaling pathways, phosphorylation in particular, and biomarker assessment in patient biofluids using state-of-the-art mass spectrometry.
In addition, his work includes community prevention and control programs in chronic diseases including diabetes, obesity, and end stage renal disease with an emphasis on survey instruments to evaluate strategies to assist in the definition of best practices in communities at high risk for these diseases. These populations will ultimately provide the diverse phenotypes of disease susceptibility and sequelae for the development of individualized biomarkers for a personalized medicine approach to disease predisposition and management. Finally, public policy, public education, and legislative affairs are important areas of his efforts to build understanding of, and appreciation for, the need for public support of the diverse strategies to improve human health.
- Stark Diabetes Center
- University of Texas Community Outreach Program
- Mitchell Center for Neurodegenerative Diseases
- Sealy Center for Molecular Medicine
- Institute for Translational Sciences
- Policy Scholar of the James A. Baker III Institute for Public Policy at Rice University
The department of internal medicine is developing evidence based clinical protocols which will be available in EPIC (as order sets) for use when admitting patients with these diagnoses. Their AIM is to standardize care and decrease length of stay and readmission rates.Currently available protocols are:
- CAP - Community Acquired Pneumonia Orderset
- Congestive Heart Failure (CHF)
- Chronic Obstructive Pulmonary Disease (COPD)
- Diabetic Ketoacidosis Adult, ICU
- General Medicine Admission
- Immunodeficiency Flow Panel
- MICU/CCU Admission Order Set
- Oral Analgesic Medicaitons
- Parenteral Opioids
- Sepsis, Adult ICU
- 111 - Stroke Alert
- 112 - Stroke Activation
- 300086 - Stroke Floor Admission
- 3000000001 - Stroke Critical care without tPA
- 300088 Stroke - Transfer from Critical care to floor
- 3004002 - Stroke Discharge
All protocols can be found in the EPIC order set section.
The department of Internal Medicine has a large role in the Meaningful Use Initiative. Our participation is key for the success of the initiative. Please visit the meaningful use website for important communication and updates from the Meaningful Use Initiative.