Sutapa Ray, Ph.D.
Sutapa Ray, Ph.D.
Division of Endocrinology
Department of Internal Medicine
University of Texas Medical Branch
8.138 Medical Research Building
Galveston, TX 77555-1060
My research interest is to investigate the role of IL-6-JAK-STAT3 signaling pathway in inflammation and acute phase response, mainly focusing on the regulation of Signal Transducer and Activator of Transcription-3 (STAT3) by post translational modification. STAT3 is a latent transcription factor activated by tyrosine and serine phosphorylation in response to many cytokines and growth factors. Earlier we discovered that interleukin-6 induces acetylation of the STAT3 NH2-terminus by the recruitment of the p300 coactivator and is essential for target gene activation and chromatin remodeling. We subsequently showed that acetylation of STAT3 at its NH2 terminus is also required for binding of other important transcriptional regulators e.g. P300, PTEFb complex, HDAC1 and APE1. My long term goal is to investigate the role of IL-6-STAT3 pathway in tissue regeneration and cellular proliferation in burn-induced hypertrophic scarring. Elucidating this pathway should demonstrate a role of STAT3 antagonists to be used as therapeutic interventions in the treatment of post burn inflammation and morbidity.
The department of internal medicine is developing evidence based clinical protocols which will be available in EPIC (as order sets) for use when admitting patients with these diagnoses. Their AIM is to standardize care and decrease length of stay and readmission rates.Currently available protocols are:
- CAP - Community Acquired Pneumonia Orderset
- Congestive Heart Failure (CHF)
- Chronic Obstructive Pulmonary Disease (COPD)
- Diabetic Ketoacidosis Adult, ICU
- General Medicine Admission
- Immunodeficiency Flow Panel
- MICU/CCU Admission Order Set
- Oral Analgesic Medicaitons
- Parenteral Opioids
- Sepsis, Adult ICU
- 111 - Stroke Alert
- 112 - Stroke Activation
- 300086 - Stroke Floor Admission
- 3000000001 - Stroke Critical care without tPA
- 300088 Stroke - Transfer from Critical care to floor
- 3004002 - Stroke Discharge
All protocols can be found in the EPIC order set section.
The department of Internal Medicine has a large role in the Meaningful Use Initiative. Our participation is key for the success of the initiative. Please visit the meaningful use website for important communication and updates from the Meaningful Use Initiative.