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Robin Stephens, Ph.D.
Assistant Professor, Division of Infectious Diseases



Robin Stephens, Ph.D., Associate Professor

Robin Stephens, Ph.D.
Assistant Professor
Department of Internal Medicine
Division of Infectious Diseases

University of Texas Medical Branch
301 University Blvd, Marvin Graves Bldg., Rm 4.210D
Galveston, Texas 77555-0435
Phone: 409.747.1860
Fax: 409.772.6527
Email: rostephe@utmb.edu

Education

Degree/Training Completed Year Name & Location
B.A. 1993 Cornell University Ithaca, NY
M.D. 1997 New York University, New York, NY
Ph.D 2001 Washington University, St. Louis, MO
Postdoctoral 2010 National Institute for Medical Research, London, England

Overview

Malaria still kills 1-2 million people a year, mostly children in sub-Saharan Africa. Vaccine work has entered a very hopeful stage, but very little is known about the factors determining immunity to this parasitic disease. Work in our laboratory focuses on the immunology and pathology of malaria infection.

Research Interests

  • CD4+ T cell memory to blood stages of Plasmodium chabaudi chabaudi (AS), mouse malaria
  • Effector function (Th1, Tfh) commitment in memory cells in malaria
  • Vaccine strategies to generate protective effector memory T cells
  • B cell memory and splenic microenvironment
  • T cell memory and cytokines in P. Falciparum infection in collaboration with field laboratories
Techniques: Multi-color flow cytometry, microchip analysis, in vivo studies

Select Publications

  1. Stephens R, Langhorne J. Effector memory Th1 CD4 T cells are maintained in a mouse model of chronic malaria. PLoS Pathog. 2010 Nov 24;6(11):e1001208. PMID: 21124875.
  2. Stephens R, Albano FR, Quin S, Pascal BJ, Harrison V, Stockinger B, Kioussis D, Weltzien HU, Langhorne J. Malaria-specific transgenic CD4(+) T cells protect immunodeficient mice from lethal infection and demonstrate requirement for a protective threshold of antibody production for parasite clearance. Blood. 2005 Sep 1;106(5):1676-84. Epub 2005 May 12. PMID: 15890689
  3. Stephens R, Culleton RL, Lamb TJ. The contribution of Plasmodium chabaudi to our understanding of malaria. Trends Parasitol. 2012 Feb;28(2):73-82. Epub 2011 Nov 17. Review. PMID: 22100995
  4. Stephens R, Ndungu FM, Langhorne J. Germinal centre and marginal zone B cells expand quickly in a second Plasmodium chabaudi malaria infection producing mature plasma cells. Parasite Immunol. 2009. Jan;31(1):20-31. PMID: 19121080

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