Scott C. Weaver, M.S., Ph.D.
Professor, Departments of Pathology and Microbiology & Immunology
Scott C. Weaver, M.S., Ph.D.
Departments of Pathology and Microbiology & Immunology
Director, Institute for Human Infections and Immunity
Scientific Director, Galveston National Laboratory
Institute for Human Infections and Immunity
Galveston National Laboratory Building, Rm 6.200
301 University Blvd.
Galveston, Texas 77555-0610
|Degree/Training Completed||Year||Name & Location|
|B.S.||1979||The College of William and Mary,
|M.S.||1982||Cornell University, Ithaca, NY|
|Ph.D.||1993||University of California, San Diego, La Jolla, CA|
|Postdoctoral Fellow||1994||Yale University School of Medicine, New Haven, CT|
The mission of the Institute for Human Infections and Immunity is to coordinate, facilitate and enhance the activities of UTMB's research centers and programs that focus on advancing the fields of infection and immunity. It is to understand the nature of infectious diseases, and work to translate new research concepts into products aimed at controlling emerging infectious diseases and mitigating their effects on society. The programs of the Institute for Human Infections and Immunity (IHII) are the hub of infectious disease research at UTMB.
IHII programs include the Galveston National Laboratory, the Center for Biodefense & Emerging Infectious Diseases, the WHO Collaborating Center for Tropical Diseases, the Sealy Center for Vaccine Development, the World Reference Center for Emerging Viruses and Arboviruses and the McLaughlin Endowment for Infection and Immunity.
My research focuses on arboviruses, including mechanisms of emergence from enzootic cycles, evolution, mosquito-virus interactions, and vaccine development. My research approaches include reverse genetics to identify adaptive mutations that mediate host range changes, and field studies in Africa and Latin America to understand the ecology and epidemiology of emerging arboviruses.
- Arrigo NC, Adams AP, Weaver SC. Evolutionary patterns of eastern equine encephalitis virus in North versus South America suggest ecological differences and taxonomic revision. J Virol 84 (2): 1014-25, 2010. PMCID: PMC2798374.
- Deardorff ER, Forrester NL, Travassos da Rosa AP, Estrada-Franco JG, Navarro-Lopez R, Tesh RB, Weaver SC. Experimental Infections of Oryzomys couesi with Sympatric Arboviruses from Mexico. Am J Trop Med Hyg 82 (2): 350-3, 2010. PMCID: PMC2813180.
- Kenney JL, Adams AP, Weaver SC. Transmission Potential of Two Chimeric Western Equine Encephalitis Vaccine Candidates in Culex tarsalis. Am J Trop Med Hyg 82 (2): 354-9, 2010. PMCID: PMC2813181.
- Volk SM, Chen R, Tsetsarkin KA, Adams AP, Garcia TI, Sall AA, Nasar F, Schuh AJ, Holmes EC, Higgs S, Maharaj PD, Brault AC, Weaver SC. Genome-scale phylogenetic analyses of chikungunya virus reveal independent emergences of recent epidemics and various evolutionary rates. J Virol 84 (13): 6497-504, 2010. PMCID: PMC2903258.
- Auguste AJ, Lemey P, Pybus OG, Suchard MA, Salas RA, Adesiyun AA, Barrett AD, Tesh RB, Weaver SC, Carrington CV. Yellow fever virus maintenance in Trinidad and its dispersal throughout the Americas. J Virol 84 (19): 9967-77, 2010. PMCID: PMC2937779.
- Deardorff ER, Weaver SC. Vector competence of Culex (Melanoconion) taeniopus for equine-virulent subtype IE strains of Venezuelan equine encephalitis virus. Am J Trop Med Hyg 82 (6): 1047-52. PMCID: PMC2877410
- Sherman MB, Weaver SC. Structure of the recombinant alphavirus Western equine encephalitis virus revealed by cryoelectron microscopy. J Virol 84 (19): 9775-82, 2010. PMCID: PMC2937749.
- Arrigo NC, Adams AP, Watts DM, Newman PC, Weaver SC. Cotton rats and house sparrows as hosts for North and South American strains of eastern equine encephalitis virus. Emerg Infect Dis 16 (9): 1373-80, 2010. PMCID: not yet available.
- Auguste AJ, Adams AP, Arrigo NC, Martinez R, Travassos da Rosa AP, Adesiyun AA, Chadee DD, Tesh RB, Carrington CV, Weaver SC. Isolation and characterization of sylvatic mosquito-borne viruses in trinidad: enzootic transmission and a new potential vector of Mucambo virus. Am J Trop Med Hyg 83 (6): 1262-5, 2010. PMCID: PMC2990042.
- Kenney JL, Volk SM, Pandya J, Wang E, Liang X, Weaver SC. Stability of RNA virus attenuation approaches. Vaccine 29 (12): 2230-4, 2011. PMCID: PMC3060670.
- Darwin JR, Kenney JL, Weaver SC. Transmission Potential of Two Chimeric Chikungunya Vaccine Candidates in the Urban Mosquito Vectors, Aedes aegypti and Ae. albopictus. Am J Trop Med Hyg 84 (6): 1012-5, 2011.
- Tsetsarkin KA, Chen R, Leal G, Forrester N, Higgs S, Huang J, Weaver SC. Chikungunya virus emergence is constrained in Asia by lineage-specific adaptive landscapes. Proc Natl Acad Sci U S A 108 (19): 7872-7, 2011. PMCID: PMC3093459.
- Forrester NL, Guerbois M, Adams AP, Liang X, Weaver SC. Analysis of intrahost variation in Venezuelan equine encephalitis virus reveals repeated deletions in the 6-kilodalton protein gene. J Virol 85 (17): 8709-17, 2011. PMCID: not yet available.
- Plante K, Wang E, Partidos CD, Weger J, Gorchakov R, Tsetsarkin K, Borland EM, Powers AM, Seymour R, Stinchcomb DT, Osorio JE, Frolov I, Weaver SC. Novel Chikungunya Vaccine Candidate with an IRES-Based Attenuation and Host Range Alteration Mechanism. PLoS Pathog 7 (7): e1002142, 2011. PMCID: PMC3145802
- Johnson BW, Kosoy O, Wang E, Delorey M, Russell B, Bowen RA, Weaver SC. Use of sindbis/eastern equine encephalitis chimeric viruses in plaque reduction neutralization tests for arboviral disease diagnostics. Clin Vaccine Immunol 18 (9): 1486-91, 2011. PMCID: PMC3165225.
- Deardorff E, Estrada-Franco J, Freier J, Navarro-Lopez R, Travasos da Rosa AP, Tesh RB, Weaver, SC. Candidate vectors and rodent hosts of Venezuelan equine encephalitis virus, Chiapas 2006-2007. Am J Trop Med Hyg. In press, 2011. PMCID: not yet available.
- Zhang R, Hryc CF, Cong Y, Liu X, Jakana J, Gorchakov R, Baker ML, Weaver SC, Chiu W. 4.4 A cryo-EM structure of an enveloped alphavirus Venezuelan equine encephalitis virus. EMBO J 30 (18): 3854-63, 2011. PMCID: not yet available.