MIME-Version: 1.0 Content-Type: multipart/related; boundary="----=_NextPart_01C99E3F.39223080" This document is a Single File Web Page, also known as a Web Archive file. If you are seeing this message, your browser or editor doesn't support Web Archive files. Please download a browser that supports Web Archive, such as Microsoft Internet Explorer. ------=_NextPart_01C99E3F.39223080 Content-Location: file:///C:/E768ED32/022509GR.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Naira Baregamian, M.D. Dai H. Chung, M.D., F.A.C.S. Grand Rounds 02/25/09

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------=_NextPart_01C99E3F.39223080 Content-Location: file:///C:/E768ED32/022509GR_files/master49.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C99E3F.39223080 Content-Location: file:///C:/E768ED32/022509GR_files/pres.xml Content-Transfer-Encoding: quoted-printable Content-Type: text/xml; charset="utf-8" ------=_NextPart_01C99E3F.39223080 Content-Location: file:///C:/E768ED32/022509GR_files/editdata.mso Content-Transfer-Encoding: base64 Content-Type: application/x-mso QWN0aXZlTWltZQAAAfAEAAAA/////wAAA/AJAAAAAAAlBAEAAAABAAAL8AQAAAASNFZ4 ------=_NextPart_01C99E3F.39223080 Content-Location: file:///C:/E768ED32/022509GR_files/slide0001.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Naira Baregamian, M.D. Dai H. Chung, M.D., F.A.C.S. Grand Rounds 02/25/09
Oxidative Stress in
   Necrot= izing Enterocolitis
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Chung, M.D., F.A.C.S. Grand Rounds 02/25/09
Goals & Objectives
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§Discuss etiology & diagnosis of <= span style=3D'position:absolute;top:32.75%;left:15.54%;width:78.65%;height:6.5%= '>Necrotizing enterocolitis (NEC) <= /div>
§Describe  clinical presentation & surgical management of NEC
§Discuss the role of oxidative stress  in injures intestine, molecular signaling mechanisms involved in NEC
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file:///C:/E768ED32/022509GR_files/slide0002.htm Content-Transfer-Encoding: quoted-printable Content-Type: text/html; charset="us-ascii" Naira Baregamian, M.D. Dai H. Chung, M.D., F.A.C.S. Grand Rounds 02/25/09
Necrotizing Enterocolitis(NEC)
=
=
§Most common GI emergency in neonates
§Prematurity is the single most important risk factor
§Well-described risk factors: ischemia, bacteria, cytokines, enteral feeding
§Exogenous  surfactant & mechanical ventilation contribute to greater numbers of premature infants at risk for developing NEC
§Significant morbidity and mortality
§Exact  etiology remains poorly understood
§Animal models are not reliable
§Cellular mechanisms involved in NEC <= span style=3D'position:absolute;top:86.25%;left:11.42%;width:58.61%;height:4.75= %'>remain undefined
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Chung, M.D., F.A.C.S. Grand Rounds 02/25/09
Necrotizing Enterocolitis (NEC)
= §Most commonly affects terminal ileum and proximal = §Varying degrees of NEC can affect any = segment of the small intestine or colon
§Pattern of disease: = single isolated area or multiple, diffuse = lesions
  Terminal
<= span style=3D'mso-spacerun:yes'>     ileum
Ileocecal
   valve
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