Therapeutics-Biotech

Methods of Diagnosing Leiomyoma by Measuring Catechol-O-methyltransferase
Ayman Al Hendy, M.D., Ph.D.

 

Miniprotein Ligands and Other Polypeptides and Methods For Making and Using Same
Robert Fox, Ph.D.; Alan D. Barrett, Ph.D.; Xiuzhen Fan, Ph.D.; Michael Holbrook, Ph.D.

 

IKK Gamma Gene Products and Methods for Making and Using Same
Allan Brasier, M.D.; Tao Hai, Ph.D.; Thomas Wood, Ph.D.; Yuanfen Wei

 

Methods of Treating Lung Inflammation
Antonella Casola, M.D.; Roberto Garofalo, M.D.; Allan Brasier, M.D.

 

Methods and Materials for Treating Autoimmune Diseases and Conditions
Premkumar Christadoss, M.D.; Erdem Tuzun, M.D.

 

Use of Thiazolidinediones Derivatives for Preventing Uterine Contractions In Premature Labor or Lactation
John A. Copland, Ph.D.; Kirk L. Ives; Melvyn Soloff, Ph.D.

 

High-Throughput Assay for Virus Entry and Drug Screening
Robert A. Davey, Ph.D.; Andrey Kolokoltsov, M.S.

 

Radiation and Nanoparticles for Enhancement of Drug Delivery in Solid Tumors
Rinat O. Esealiev, Ph.D.

 

SIRNA Inhibition of PI3K P85, P110, and AKT2 and Methods of Use
B. Mark Evers, M.D.; Piotr G. Rychahou, M.D., Ph.D.

 

Large Scale Production of Packaged Alphavirus Replicons
Ilya Frolov, Ph.D.; Elena Frolov, Ph.D.

 

Uses of Tetrahydrobiopterin for Treating Gastroparesis
Pankaj J. Pasricha, M.D.; Pandau R. Gangula, Ph.D.

 

Troglitazone Compounds for Treating Climacteric and Cancer
Randall J. Uban, Ph.D.; Allan Green, Ph.D.

 

Methods and Materials for Pain Management
Li-Yen Mae Huang, Ph.D.; Yanping Gu, Ph.D.; Ya Xu, M.D.

 

Methods and Compositions for Vaccination Against or Involving Enterobacteriaceae Bacteria
Gary R. Klimpel, Ph.D.; David W. Niesel, Ph.D.; Ashok Chopra, CSc, Ph.D.; Jian Sha, M.D., MS

 

Reverse Genetic System for Rift Valley Fever Virus and Uses Thereof
Shinji Makino, DVM, Ph.D.; Tetsuro Ikegami, Ph.D.; Clarence J. Peters, M.D.; Sungyong Won, Ph.D.

 

Methods and Compositions for Delivering Enzymes and Nucleic Acid Molecules to Brain, Bone and Other Tissues
Reuben Matalon, M.D., Ph.D.

 

Methods and Compositions for the Treatment of Attention Deficit Hyperactivity Disorder and Hyperphenylalanemia
Reuben Matalon, M.D., Ph.D.; Ofer Matalon, Ph.D.

 

Use of CD63 Inhibitors
William A. O'Brien, M.D.; Kathie Grovit-Ferbas, Ph.D.

 

Treatment of Disorders By Implanting Stem Cells and/or Progeny Thereof Into Gastrointestinal Organs
Pankaj J. Pasricha, M.D.; Maria-Adelaide Micci, Ph.D.

 

Method of Identifying Antinociceptive Compounds Using Protease Activated Receptor-2
Pankaj J. Pasricha, M.D.; Willemijntje A. Hoogerwerf, Ph.D.; John Winston, Ph.D.; Maria-Adelaide Micci, Ph.D.; Helen Hellmich, M.D.; Mohan Shenoy, Ph.D.

 

Treatment of Irritable Bowel Syndrome and Related Bowel Diseases
Pankaj J. Pasricha, M.D.

 

Method of Increasing Gastric Emptying
Pankaj Jay Pasricha, M.D.; Maria-Adelaide Micci, Ph.D.

 

Polypeptide That Interacts With Heat Shock Proteins
Winston C. Patterson, M.D.; Carol A. Ballinger, Ph.D.

 

3' Sequence of the GB Virus B (GBV-B) Genome
David V. Sangar, Ph.D.; Stanley M. Lemon, M.D.

 

Methods and Compositions Involving Nucleotide Repeat Disorders
Partha Sarkar, Ph.D.; Tetsuo Ashizwa, M.D.; Weidong Xu, Ph.D.

 

Method for Designing a Potential Inhibitor of Glutathione-Aldehyde Conjugate Binding To Aldose Reductase
Satish K. Srivastava, Ph.D.; Aurni Bhatnagar, Ph.D.; Kota V. Ramana, Ph.D.

 

Thermostable UvrA and UvrB Polypeptides and Methods of Use
Bennett Van Houten, Ph.D.; Milan Skorvaga, Ph.D.

 

Plasmodium Sp. Chitinase
Joseph M. Vinetz, M.D.

 

Rickettsia Felis Outer Membrane Protein
Donald H. Bouyer, Ph.D.; Patricia Crocquet-Valdes; John Stenos, Ph.D.; David H. Walker, M.D.

 

Viral Pseudo-Capsids Including Assembly Agonists and Antagonists
Stanley J. Watowich, Ph.D.; Meghan Kunkel, Ph.D.; Marta Lorinczi, Ph.D.

 

Method of Producing Region-Specific Neurons From Human Neuronal Stem Cells
Ping Wu, M.D., Ph.D.

 

Phosphorylation of 5-lipoxygenase at ser523 and Uses Thereof
Yochi Birnbaum, Ph.D.

 

Methods of Increasing cAMP levels and Uses Thereof
Yochi Birnbaum, Ph.D.

 

Uses of Selective Cyclooxygenase-1 Inhibitors
Yochi Birnbaum, Ph.D.

 

Inhibition of Inositol 1,4,5-Triphosphate Receptor Calcium Channel/Cytochrome c Interactions and Uses Thereof
Darren F. Boehning, Ph.D.; Jose M. Barral, M.D., Ph.D.

 

Methods for Inhibiting Allergic Inflammation and Other Responses Initiated by Pollens, Molds, and Other Non-Animal Derived Allergens
Istvan Boldogh, Ph.D.; Sanjiv Sur, M.D.

 

Method and Biomarkers for the Detection of Dengue Hemorrhagic Fever
Tadeusz Kochel, Ph.D.; Josefina Nores Garcia, Ph.D.; Allan Brasier, M.D.; Adrian Recinos, Ph.D.; John E Wiktorowicz, Ph.D.; Heidi Spratt, Ph.D.; Hyunsu Ju, Ph.D.

 

Novel Small Chemical Inhibitors for Exchange Protein Directly Activated by cAMP (EPAC)
Xiaodong Cheng, Ph.D.; Jia Zhou, Ph.D.; Tamara Tsalkova, Ph.D.; Fang Mei, Ph.D.; Haijun Chen, Ph.D.

 

Production of and Uses for Decellularized Lung Tissue
Joaquin Cortiella, M.D.; Joan E. Nichols, Ph.D.; Jean A. Niles

 

Inhibition of Filovirus Entry Into Cells and Uses Thereof
Robert A. Davey, Ph.D.; Andrey A. Kolokoltsov, Ph.D.; Mohammad F. Saeed, Ph.D.

 

Methods and Compositions Related to a Triple Combination Cancer Therapy
Jianli Dong, Ph.D.; Gengming Huang, Ph.D.

 

UNC-45A Splice Variants Based Cancer Diagnostics and Therapeutics
Henry Fredric Epstein, M.D.; Wei Guo, Ph.D.; Daisi Chen, Ph.D.; Ram Singh, Ph.D.

 

Ultrasound-Based Treatment Methods for Therapeutic Treatment of Skin and Subcutaneous Tissues
Rinat O. Esenaliev, Ph.D.

 

Noninvasive Therapies In the Absence or Presence of Exogenous Particulate Agents
Rinat O. Esenaliev, Ph.D.

 

Attenuation of Encephalitogenic Alphavirus and Uses Thereof
Ilya V. Frolov, Ph.D.; Elena Frolova, Ph.D.; Scott C. Weaver, Ph.D.

 

Chimeric Chikungunya Virus and Uses Thereof
Ilya V. Frolov, Ph.D.; Scott C. Weaver, Ph.D.; Eryu Wang, M.D., Ph.D.

 

Uses of Morelloflavone
Kenichi Fujise, M.D.; Nongporn Towatana, Ph.D.; Wilawan Mahabusarakam, Ph.D.

 

Diagnosis and Treatment of Trypanosoma Cruzi Infection and Chagas Disease
Nisha J. Garg, Ph.D.

 

Antibody-Mediated Modulation of Allergy
Randall M. Goldblum, M.D.; Terumi Midoro-Horiuti, M.D., Ph.D.; Bo Ning, Ph.D.; Ruby Tiwari, Ph.D.

 

Chikungunya Virus Infectious Clones and Uses Therefor
Stephen T. Higgs, Ph.D.; Dana L. Vanlandingham, Ph.D.; Konstantin Tsetsarkin, Ph.D.

 

Upregulation of Opioid Receptors for Pain Management
Li-Yen Mae Huang, Ph.D.; Yanping Gu, Ph.D.

 

Methods and Compositions for Treatment of Reperfusion Injury and Other Cardiac Conditions
Ming-He Huang, Ph.D.; Yochai Birnbaum, Ph.D.; Barry F. Uretsky, M.D.

 

Reducing Myocardial Reperfusion Injury by the Combination Therapy of Protein Kinase A Activation and B1-Adrenegic Receptor Blockade
Ming-He Huang, Ph.D.; Yochai Birnbaum, Ph.D.; Barry F. Uretsky, M.D.

 

Inhibitor of dsRNA-Dependent Protein Kinase (PKR) as an Enhancer of Bunyavirus Live-Attenuated Vaccines
Tetsuro Ikegami, Ph.D.; Birte Kalveram, Ph.D.; Sabarish Indran, Ph.D.; Olga Lihoradova, Ph.D.; Alexander Freiberg, Ph.D.

 

Compositions and Methods Related To Poloxamer Copolymer Membrane Sealant
Rakez Kayed, Ph.D.

 

Antibodies That Bind Tau Oligomers
Rakez Kayed, Ph.D.

 

Antibodies That Bind Amyloid Oligomers
Rakez Kayed, Ph.D.

 

Methods and Compositions for Treating Phenylketonuria
Reuben Matalon, M.D., Ph.D.

 

Ex Vivo Human Lung/Immune System Model Using Tissue Engineering for Studying Microbial Pathogens With Lung Tropism
Joan E. Nichols, Ph.D.; Joaquin Cortiella, M.D.; Ronald P. Mlcak, Ph.D.; Jean A Niles

 

Autologous Somatic Cells from Peripheral Blood and Uses Thereof
Joan E. Nichols, Ph.D.; Joaquin Cortiella, M.D.; Jean A. Niles; Eric Lee, Ph.D.; Donald Prough, M.D.

 

Antagonists of the Transient Receptor Potential Vanilloid 1 and Uses Thereof
Jiande Chen, Ph.D.; Pankaj Jay Pasricha, M.D.; Rami Hawari, Ph.D.

 

Transient Receptor Potential Vanilloid 1 and Uses Thereof
Pankaj J. Pasricha, M.D.; John H. Winston, Ph.D.

 

Neurotoxin Therapy for Postprandial Hyperglycemia
Pankaj J. Pasricha, M.D.

 

Modulation of Nerve Pain Activity by Resiniferatoxin and Uses Thereof
Pankaj J. Pasricha, M.D.

 

Post-Translational Regulation of Catalytic Activities of Cytochrome P450 46A1 and Uses Thereof
Irina A. Pikuleva, Ph.D.; Natalia V. Mast, Ph.D.

 

Treatment for Neuropathic Pain Due to Spinal Cord Injury
Regino Perez-Polo, Ph.D.

 

S-Nitrosylation of Glucosylating Toxins and Uses Therefor
Tor C. Savidge, M.D.; Jonathan Stamler, Ph.D.

 

Novel Allosteric Therapeutics for Clostridium Difficile Infection (CDI)
Tor C. Savidge, M.D.

 

Physicochemical (PCP) Based Consensus Sequences and Uses Thereof
Catherine H. Schein, Ph.D.; Petr Danecek, Ph.D.

 

Methods Involving Aldose Reductase Inhibitors-Sepsis
Satish K. Srivastava, Ph.D.; Venkat Ramana, Ph.D.; Aruni Bhatnagar, Ph.D.

 

Treatment of Cancer with Aldose Reductase Inhibitors (Colon, Lung, Breast and Prostate Cancer)
Satish K. Srivastava, Ph.D.; Kota V. Ramana, Ph.D.

 

Methods Involving Aldose Reductase Inhibitors
Satish K. Srivastava, Ph.D.; Kota V. Ramana, Ph.D.

 

Methods for Treating COPD
Satish K. Srivastava, Ph.D.; Kota V. Ramana, Ph.D.; Umesh C. Yadav, Ph.D.

 

Bcl-2 Promoted Cell Death
Giulio Taglialatela, Ph.D.; Bryce Portier, Ph.D.

 

Method of Diagnosing and Treating Ehrlichia
David H. Walker, M.D.; Sunil Thomas, Ph.D.

 

Diagnosis and Treatment of Erlichiosis
Sunil Thomas, Ph.D.; David H. Walker, M.D.

 

Compositions and Methods for Preventing or Treating Burkholderia Infection
Alfredo G. Torres, Ph.D., D. Mark Estes, Ph.D.

 

Regulation of Brain Natriuretic Peptide and Catecholamines for the Treatment of Cardiovascular Diseases
Ming-He Huang, M.D., Ph.D.; Barry Uretsky, M.D.

 

Fusogenic Virus-like Particles and Uses Thereof
Pramila Walpita, Ph.D.

 

Small Molecule Inhibitors of Dengue and West Nile Virus Proteases
Stanley J. Watowich, Ph.D.; Suzanne M. Tomlinson, Ph.D.; Scott Gilbertson, Ph.D.

 

Chimeric Sindbis-Eastern Equine Encephalitis Virus and Uses Thereof
Ilya Frolov, Ph.D.; Patricia V. Aguilar, Ph.D.; Scott C. Weaver, Ph.D.; Slobodan Paessler, DVM, Ph.D.

 

Chimeric Sindbis-Western Equine Encephalitis Virus and Uses Thereof
Ilya Frolov, Ph.D.; Scott C. Weaver, Ph.D.

 

Single Stranded DNA Aptamers Binding NF-kB/RelA
Steven G. Widen, Ph.D.; Thomas G. Wood, Ph.D.; Allan R. Brasier, M.D.; Yingxin Zhao, Ph.D.

 

Sheep Model of Neuropathic Pain Behavior and Uses Thereof
Denise M. Wilkes, Ph.D.; Li-Yen M. Huang, Ph.D.

 

Allosteric Modulators of 5-Hydroxytryptamine 2C Receptor (5-HT2CR)
Jia Zhou, Ph.D.; Chunyong Ding, Ph.D.; Kathryn A. Cunningham, Ph.D.

 

Bivalent AMPA Receptor Positive Allosteric Modulators
Jia Zhou, Ph.D.; Haijun Chen, Ph.D.; Kenneth M. Johnson, Ph.D.; Cheng Z. Wang, Ph.D.