Diego Rincon-Limas

Dineley, Kelly T., Ph.D.

Assistant Professor

Affiliations: Department of Biochemistry & Molecular Biology

Phone: (409) 747-4535
Fax: (409) 747-2555
Email: ktdinele@utmb.edu

Research Interests:  please click here

Current Projects

1) Physiological role of Ab – nAChR Interaction in Health and Disease
2) Hyperinsulinemia as a Risk Factor for AD
3) Role of NF-
kB Signaling Axis in Ab – Induced Cognitive Impairment
4) Calcineurin as a Mediator of A
b – Induced Cognitive Impairment
5) Mass-Spectrometry Identification of Therapeutic Targets in Early and Late AD
6) Proteome of Nicotine – Conditioned Context Associations

Selected Publications

Cole, A.R., Noble, W., van Aalten, L., Yoshida, H., Plattner, F., Meimaridou, R., Hogan, D., LaFrancois, J., Taylor, M., Gunn-Moore, F., Verkhratsky, A., Oddo, S., La Ferla, F., Duff, K., Goedert, M., Giese, K.P., Dineley, K.T., Richardson, J.C., Hanger, D.P., Allan, S.M., Sutherland, C. (2007) Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer’s disease progression.  J. Neurochem.  103(3):1132-44, 2007 Nov.

Dineley, K.T., Hogan, D., Ru, W., Taglialatela, G. (2007) Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice.  Neurobiol. Learn. Mem.  88(2):217-24, 2007 Sep.

Jones IW, Westmacott A, Chan E, Jones RW, Dineley K, O'Neill MJ, Wonnacott S. (2006) Alpha7 nicotinic acetylcholine receptor expression in Alzheimer's disease: receptor densities in brain regions of the APP(SWE) mouse model and in human peripheral blood lymphocytes. J Mol Neurosci. 30(1-2):83-84.

Hotte M., Thuault S., Dineley K.T., Hemmings H.C., Nairn A.C., Jay T.M. (2006) Phosphorylation of CREB and DARPP-32 during late LTP at hippocampal to prefrontal cortex synapses in vivo.  Synapse. 61(1):24-28.

 Hotte M., Thuault, S.J., Lachaise F., Dineley K.T., Hemmings H.C., Nairn A.C., Jay T.M. (2006) D1 receptor modulation of memory retrieval performance is associated with changes in pCREB and pDARPP-32 in rat prefrontal cortex.  Behavioral Brain Research.  171:127-133.

Bell, K.A., O’Riordan, K.J., Sweatt, J.D. and Dineley, K.T.  (2004) MAPK recruitment by b-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time.  J. Neurochem.  91:349-361.

Wang, R., Dineley, K.T., Sweatt, J.D. and Zheng, H. (2004) Presenilin 1 familial Alzheimer’s disease mutation leads to defective association learning and impaired adult neurogenesis.  Neurosci. 126:305-312

Galvan, C.D., Wenzel, J.H., Dineley, K.T., Lam, T.T., Schwartzkroin, P.A., Sweatt, J.D. and Swann, J.W.  (2003) Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo.  Eur. J. Neurosci. 18:1861-1872.

Dineley K.T., Bell K.A., Bui D., and Sweatt J.D. (2002) b-amyloid peptide activates a7 nicotinic acetylcholine receptors expressed in Xenopus oocytes.  J. Biol. Chem. 277:25056-25061.

Dineley K.T., Xia X., Bui D., Sweatt J.D. and Zheng H. (2002) Accelerated plaque accumulation, associative learning deficits and up-regulation of a7 nicotinic acetylcholine receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. J. Biol. Chem. 277:22768-22780.

Adams J.P., Anderson A.E., Varga A.W., Dineley K.T., Cook R.G., Pfaffinger P.J., and Sweatt J.D. The A-type potassium channel, Kv4.2, is a substrate for the mitogen activated protein kinase, ERK.  J. NeuroChem. 75:2277-2287; 2000.

Dineley, K.T., Westerman, M, Bui D, Bell, K, Ashe, KH, and Sweatt, JD, Beta-amyloid actvates the mitogen-activated protien kinase cascade via hippocampal alpha 7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease. J Neurosci, 2001. 21:4125-33.

Dineley, KT, Bell, KA, Bui, D, and Sweatt, JD, Beta-amyloid peptide activates alpha 7 nicotinic acetylcholine receptors expressed in Xenopus oocytes. J Biol Chem, 2002. 277:25056.

Dineley, KT, Xia, X, Bui, D, Sweatt, JD, and Zheng, H, Accelerated plaque accumulation, sassociative learning defecits and up-regulation of alpha 7 nicotinic receptor protien in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. J Biol Chem, 2002. 277:22768.

Bell, KA, o'Riordan, KJ, Sweatt, JD, and Dineley, KT. (2004) MAPK recruitment by beta-amyloid in organotypic hippocampal slide cultures depends on physical state and exposure time. J. Neurochem 91:349.