Bill T. Ameredes, Ph.D. is an Associate Professor of Medicine, and Director of Fellow Research Training, in the APICS Division, at the University of Texas Medical Branch.
Dr. Ameredes earned his Bachelor of Science degree in 1981 and Master of Science degree in Biology in 1984, at the University of Akron, and went on to earn his Doctor of Philosophy degree in Physiology, at the Ohio State University in 1989. He conducted his postdoctoral fellowship at the University of Florida from 1989-1992, during which time he was an American Heart Association Research Fellow. Afterward, he joined the faculty at the University of Pittsburgh in the Division of Pulmonary, Allergy, and Critical Care Medicine, where he conducted research in Pulmonary Physiology for over 13 years, with funding from the American Heart Association, American Lung Association, American Respiratory Alliance of Western Pennsylvania, and the National Institutes of Health. His current work at the University of Texas is supported by funding from the NIH and other sources.
Beginning with his Masters’ work, Dr. Ameredes has performed physiology research in humans, and in animal models of disease, as well as in cellular and molecular models, including cell cultures. His work has focused on applied pulmonary and cardiovascular investigations in disease areas including hypertension, chronic obstructive pulmonary disease, and asthma, as well as basic investigations of control of hyperemia during exercise, muscle metabolism, and the role of cytokines and small gaseous molecules in airway inflammation and hyperresponsiveness. He has published 35 papers and over 100 abstracts in these areas since 1983. His recent work focuses on the role of nitric oxide and carbon monoxide in regulation of the cytokine network in airway inflammation, regulation of airway smooth muscle contractile hyperresponsiveness, in murine models, and in human airway smooth muscle cell culture models of allergic airway inflammation. Current studies include the role of IL-10 in the resolution of airway inflammation, the role of mitogen-activated protein kinases in the development and resolution of airway inflammation through the use of transgenic mice with genetically-targeted deletions of IL-10, iNOS, and critical kinasessuch as MKK3 and JNK1, and studies of beta-receptor-modulated cytokine production by beta-agonists in airway smooth muscle cells.
Dr. Ameredes is a member of the American Physiological Society and the American Thoracic Society, and is a scientific reviewer for the Journal of Applied Physiology, the American Journal of Physiology, the American Journal of Respiratory and Critical Care Medicine, and the American Journal of Respiratory Cell and Molecular Biology, among others. He teaches pulmonary physiology to graduate students, medical students, and fellows, and he is responsible for guidance of the fellows in basic and applied research in allergy and pulmonary medicine
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