Liquid chromatography-mass spectrometry (LC-MS)

Gas chromatography-mass spectrometry (GC-MS)

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UTMB-CET: Synthetic Organic Chemistry Core

The Synthetic Organic Chemistry Core (SOCC) at UTMB was established in 1998 to study and develop new methods and protocols for the synthesis of modified nucleosides representing known DNA damage, and for conversion of these nucleosides into phosphoramidites that can be conveniently and site-specifically incorporated into synthetic DNA sequences. The SOCC also develops methods for incorporating lesion sites into oligonucleotides via post-synthesis methods and protocols for purifying and analyzing these defined products. The synthetic organic services provided have also been adapted and expanded over the past 10 years to accommodate a growing need for synthesis and purification of other small molecules and bioconjugates that are of interest to biomedical and environmental health researchers at UTMB and elsewhere. This area of synthesis continues to grow rapidly with expansion of the Integrative Health Sciences Facility Core's Exposure Assessment and Biomarker Development Facility and its focus on assay development for monitoring exposure and disease.

The SOCC fulfills two main purposes:

  1. To provide a cost-effective, on-campus chemical synthesis facility with expertise in the synthesis of defined chemical DNA lesions either unavailable elsewhere or prohibitively expensive commercially, as well as other unavailable organic molecules, bioconjugates and biomarkers for biological, medical and environmental health research.
  2. To reduce costs for this service by sharing these resources and their maintenance campus-wide among several research groups who use the facility. Maintenance of the SOCC's equipment is taken care of daily by trained and qualified personnel at minimal costs to researchers through charge-back fees for services.

The SOCC program for achieving these goals utilizes known literature methods and develops new methods and protocols when necessary. The SOCC specifically has expertise in the synthesis of modified nucleosides representing known site-specific DNA damage and also development of methods and protocols for purifying and analyzing these defined products.

The SOCC is relocated in a 1200 ft² laboratory space in Ewing Hall. The SOCC is located in newly renovated space (Rm. 2.130) adjacent to the Environmental Exposure Facility supported by the Sealy Center for Environmental Health and Medicine. The SOCC comprises 4 separate areas: an instrument room, chemistry lab, DNA synthesis lab and glassware cleaning and storage area. Close proximity to UTMB's Dockside NMR facility also facilitates the SOCC's NMR monitoring of chemical reactions, and analysis of products and intermediates. The SOCC also has access to a newly purchased LC-MS located in the Exposure Assessment and Biomarker Development Facility within the Integrative Health Sciences Facility.

Core Director and Members

Structure

Richard P. Hodge, Ph.D.
Director, Synthetic Organic Chemistry Service Core, Scientist, Sealy Center for Environmental Health & Medicine
Linda C. Hackfeld, M.S.
Member, Synthetic Organic Chemistry Service Core, Research Associate III, Sealy Center for Environmental Health & Medicine
Omar Guerra, B.S.
Member, Synthetic Organic Chemistry Service Core, Research Associate I, Sealy Center for Environmental Health & Medicine

Important Links

SOC Forms & Pricing:

Third Column

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