Collaborative Research Team Members
Environmental Determinants of Viral Bronchiolitis. This CRT draws much of its membership from the Asthma Pathogenesis Research Core in the previous UTMB-CET structure. The CRT extends research on the interactions of viral infections with second-hand tobacco smoke in modulating inflammatory responses in the lungs in a mouse model and in children. Asterisks denote UTMB-CET members.
| Investigator | CRT Role |
|---|---|
| R. Garofalo, MD* | Leader, Mentor |
| A. Casola, MD* | Leader, Mentor |
| D. Kolli, PhD | Investigator |
| J. Wiktorowicz, PhD | Investigator, Proteomics |
| A. Brasier, MD* | Investigator, CTSA Director |
| A. Kurosky, PhD* | Investigator, Protoemics |
| I. Boldogh, PhD* | Investigator |
| W. Calhoun, MD* | Clinical Investigator |
| H. Spratt, PhD | Investigator, Bioinformatics |
| Y. Hosakote, PhD | Investigator |
| M. Gupta, MD | CTSA K12 trainee (Garofalo) |
| D. Esham, MD | CTSA pilot investigator |
| B. Xiaoyong, PhD | Investigator, CRSP trainee (Casola) |
| T. Wood, PhD* | Investigator, Genomics |
| J. Grady, PhD | Investigator-Biostatistics |
| S. Jain, MD | Investigator |
| K. Rajarathnam, PhD | Investigator |
| L. Hallberg, PhD | Investigator |
| P. Piedra, MD | Investigator |
Severe Asthma Collaborative Research Team (SACRT). This CRT conducts ongoing studies characterizing unique patterns of protein expression in bronchiolar alveolar lavage samples from asthma patients to investigate the role of ambient air pollution in exposed populations. The leader is William J. Calhoun, MD, Director of the Coordination Core of the CTSA. Asterisks denote UTMB-CET members.
| Investigator | CRT Role |
|---|---|
| W. Calhoun MD* | Leader, Mentor |
| C. Prys-Picard MBBS PhD | Trainee (Calhoun) |
| B. Ameredes PhD* | Investigator |
| M. Moore PhD | Biorepository Director |
| H. Ju PhD* | Investigator, Biostatistics |
| A. Kurosky PhD* | Investigator, Proteomics |
| J. Wiktorowicz PhD | Investigator, Proteomics |
| A. Brasier MD* | Investigator, CTSA Director |
Role of Oxidative Stress in Lung Inflammation in Asthma, Chronic Obstructive Pulmonary Disease (COPD), and Lung Cancer. This CRT comprises a collaboration among investigators formerly in the Asthma Pathogenesis and DNA Repair and Mutagenesis Research Cores of the UTMB-CET. The CRT is investigating the role of oxidative stress and lung inflammation associated with asthma, COPD, and lung cancer. Both environmental etiologies and endogenous mechanisms of induction of pulmonary oxidative stress are being studied. Asterisks denote UTMB-CET members.
| Investigator | CRT Role |
|---|---|
| S. Sur, MD* | Leader |
| I. Boldogh, Ph.D.* | Investigator |
| V. Cardenas, MD | Clinical Investigator, Mentor |
| T. Hazra, PhD* | Investigator, UTMB-CET pilot project grant recipient |
| A. Kurosky, PhD* | Investigator, Proteomics |
| S. Mitra, PhD* | Investigator |
| M. Willis, MD | Clinical Trainee (Cardenas) |
Role of Aldose Reductase (AR) in Inflammatory Disease Mechanisms. This CRT establishes a collaborative study by investigators in the Oxidative Stress and Signaling, and Asthma Pathogenesis Research Cores in the UTMB-CET. It is based on the discovery that inhibition of AR imparts anti-inflammatory effects that improve outcomes in colon cancer, asthma, and ocular disease. The basic research findings are now leading to the development of a clinical trial using an AR inhibitor. Asterisks denote UTMB-CET members.
| Investigator | CRT Role |
|---|---|
| S. Srivastava, PhD* | Leader, Mentor |
| E. van Kuijk, MD/PhD | Clinical Investigator, Mentor |
| K. Ramana, PhD | Investigator |
| N. Ansari, PhD* | Investigator |
| I. Boldogh, PhD* | Investigator |
| U. Yadav, PhD | Postdoctoral Trainee (Srivastava) |
| Tammali, PhD | Investigator |
| Aramati, PhD | Investigator |
| N. Kalariya, PhD | Postdoctoral Trainee (van Kuijk) |
| S. Sur, MD* | Clinical Investigator |
Hepatocellular Carcinoma. This CRT conducts studies with a serological specific focus on both biomarker discovery for early detection of hepatocellular carcinoma, and the role of ROS and environmental toxins in liver cancer. Asterisks denote UTMB-CET members.
2D-Differential in gel electrophoresis on patient pre-cancerous (Cy3) and heptocellular carcinoma (Cy5) serological samples.
| Investigator | CRT Role |
|---|---|
| C. Elferink, PhD* | Leader, Mentor, CTSA pilot project grant recipient |
| L. Ciacalese, MD | Mentor, Transplant surgery |
| B. Luxon, PhD* | Mentor, Bioinformatics |
| H. Ju, PhD* | Investigator-Biostatistics |
| J Petersen, PhD | Investigator-Pathology |
| J. Sun, PhD | Investigator |
| I. Boldogh, PhD* | Investigator, Mentor |
| H. Spratt, PhD | K25 Trainee (Luxon) |
| M. Mustafa, PhD | Postdoctoral Trainee (Elferink) |
| A. Duchini, MD | Clinical investigator, Gastroenterology |
Mechanisms of Environmental Estrogen Toxicity. This CRT comprises a multi-institution collaborative team which is investigating mechanisms of toxicity of Bisphenol A and related compounds in human populations and in wildlife. Specific health outcomes of interest include asthma, reproductive effects, breast and endocrine tissue cancers, and behavioral effects. Asterisks denote UTMB-CET members.
| Investigator | CRT Role |
|---|---|
| C. Watson, PhD* | Leader, Mentor and UTMB-CET pilot project grant recipient |
| D. Crews | Investigator, Mentor |
| K. Cunningham, PhD | Investigator |
| K. Johnson, PhD | Investigator |
| P. Thomas, PhD | Investigator, Mentor |
| G. Ansari, PhD* | Investigator, IHSFC Exposure Assessment Facility Director |
| A. Landry, PhD | Investigator |
| D. Cowan, PhD | Investigator |
| T. Midori-Horiuti, PhD* | Investigator, Mentor and UTMB-CET pilot project grant recipient |
| R. Goldblum, MD* | Investigator, Clinician |
| S. Petronella, PhD* | Investigator, COEC Director |
| D. Estes, PhD | Investigator |
| B. Kaphalia, PhD* | Investigator, IHSFC Exposure Assessment Facility |
| R. Alyea, PhD | Postdoctoral Trainee (Thomas) |
| J. Guptarak, PhD | Postdoctoral Trainee (Watson) |
| Y. Nakajima, PhD | Postdoctoral Trainee (Midoro-Horiuti) |
Third Column
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