ORGANIZATION OF THE MEETING
MAIN SCIENTIFIC SESSIONS WILL FOCUS ON SIX TOPICS AND WILL BE COMPLEMENTED BY A POSTER SESSION.
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Session I. Tolerance, Immunity, and Antigen Presentation in the Liver
Session II. Regulation and Subversion of Innate and Adaptive Intrahepatic Immunity
Session III. Regulation of Adaptive Cellular Immunity in the Liver
Session IV. Immunity, Inflammation, and Liver Injury
Session V. Natural Lymphocytes, Immunity, and Immunopathology
Session VI. Natural Lymphocytes, Dendritic Cells, and the Interface of Innate and Adaptive Immunity
Session VII. Autoimmunity and the Live
HYPOTHESES TO BE DISCUSSED
Three hypotheses have been selected as the guiding motif for the meeting. These will be introduced at the beginning of the meeting and session Chairs will be encouraged to revisit them to guide discussion. They will also be debated in a special session at the end of the meeting.
Hypothesis 1: "Liver antigen presentation determines the outcome of liver infection" versus "Innate immune mechanisms determine the outcome"
Hypothesis 2: "Rational treatment of chronic viral hepatitis will involve blocking liver-specific T cell inhibitory pathways, for instance PD-1" versus "In the context of immunopathology, blocking T cell inhibitory pathways will precipitate severe liver injury"
Hypothesis 3: "Autoimmune hepatitis is a dysfunction of antigen-specific immunity" versus "Autoimmune hepatitis is a dysfunction of innate immune mechanisms"