Day1: Fri, Jan 25, 2008

Opening Session
8:00-8:10 Welcome
Chris Walker, Lewis Lanier and Stan Lemon

8:10-8:20 Introduction to the Meeting Hypotheses
Nick Crispe, Rochester

8:20-8:45 Ultrastructure and microanatomy of the liver
Irwin Arias, Boston

Session I.   Tolerance, Immunity, and Antigen Presentation in the Liver

8:45-9:10 T cell activation inside versus outside the liver
Patrick Bertolino, Sydney

9:10-9:30 The role of innate signals in hepatitis
Karl Lang, Zurich

9:30-9:50 Immunobiology of liver sinusoidal epithelial cells
Percy Knolle, Bonn

9:50-10:00 Coffee Break

10:00-10:20 Liver dendritic cell subsets
Angus Thomson, Pittsburgh

10:20-10:40 Antigen presentation by stellate cells
Florian Winau, Berlin

10:40-11:00 Liver transplantation and local antigen presentation
Nick Crispe, Rochester NY

11:00-11:30 Discussion

11:30-1:00 Lunch

Session II. Regulation and Subversion of Innate and Adaptive Intrahepatic Immunity
1:00-1:20 The genetics of innate immunity
Bruce Beutler, La Jolla (IB)

1:20-1:40 The role of Toll-like receptors and RIG-I-like helicases in antiviral responses
Shizuo Akira, Osaka (IB)

1:40-2:00 Regulation of interferon gene expression and virus infection of the liver
Takashi Fujita, Kyoto

2:00-2:20 Differential cellular adaptors mediating innate and adaptive immunity
Takashi Saito, Yokohama (IB)

2:20-2:40 RIG-I signaling in HCV infection
Michael Gale, Seattle (HP)

2:40-3:00 Innate immune responses in HAV infection
Stan Lemon, Galveston

3:00-3:20 Peptide 25: a unique immunomodulator for the control of innate and acquired immunity
Kiyoshi Takatsu, Toyama

3:20-3:40 Discussion

3:40-4:00 Coffee Break

Session III. Regulation of Adaptive Cellular Immunity in the Liver
4:00-4:20 PD-1 and T cell anergy in chronic hepatitis C
Arash Grakoui, Atlanta

4:20-4:40 Beyond PD-1: other strategies to silence effector T cells in the chronically infected host
Rafi Ahmed, Atlanta (IB)

4:40-5:00 T helper cell differentiation and regulatory functions
Kazuo Sugamura, Sendai (IB)

5:00-5:20 Mechanisms of T helper cell failure in chronic hepatic viral infections
Paul Klenerman, Oxford

5:20-5:40 Under the immunological radar: virus dose determines the outcome of HBV infection
Frank Chisari, La Jolla

5:40-6:00 Discussion

END DAY 1

Day2: Sat, Jan 26, 2008

Session IV.  Mechanisms of Liver Injury

8:30-8:50 Toll-like receptors and hepatocellular injury
David Brenner, San Diego

8:50-9:10 Stellate cell influences on T cells, dendritic cells and fibrosis
Scott Friedman, New York

9:10-9:30 Inflammation and adipogenesis
Anna Mae Diehl, Durham

9:30-9:50 Discussion

9:50-10:10   Coffee Break

10:10-10:30 Interferon Regulatory Factor 3 and hepatotoxicity in viral infections
Genhong Cheng, Los Angeles

10:30-10:50 HCV proteins and oxidative stress in liver injury
Kazuhiko Koike, Tokyo (HP)

10:50-11:10 Chronic hepatitis C, immunity, and liver Injury: Decoding the HALT-C Trial
Chihiro Morishima, Seattle

11:10-11:30 Discussion

11:30-1:00  Lunch and Break

Session V.  Natural Lymphocytes, Immunity, and Immunopathology
1:00-1:20 NK cells, cytokines, and the liver
Cliona O’Farrelly, Dublin

1:10-1:30 NK cell-mediated liver damage in HBV infection
Mala Maini, London

1:30-1:50 NK cells and immune surveillance in liver fibrosis
Bin Gao, Bethesda

1:50-2:10 Regulating signaling pathways for shaping NK cell responses to viruses and cytokines
Christine Biron, Providence

2:10-2:30 NKT cells and protection from liver injury
Jorg Reimann, Ulm

2:30-3:00 Discussion

3:00-3:20 Break

Session VI. Natural Lymphocytes, Dendritic Cells, and the Interface of Innate and Adaptive Immunity
3:20-3:40 NKT cells and bacterial immunity in the liver and elsewhere  
Mitch Kronenberg, La Jolla (IB)

3:40-4:00 Intraepithelial lymphocytes and innate immunity
Hiroshi Kiyono, Tokyo (IB)

4:00-4:20 Regulation and function of intraepithelial lymphocytes
Bana Jabri, Chicago

4:20-4:40 NK cell signaling in innate and adaptive immunity
Lewis Lanier, San Francisco (IB)

4:40-5:00 NK and NKT-dendritic cell interactions in HCV infection
Tatsuya Kanto, Osaka (HP)

5:00-5:20 Sphingomonas cell wall antigens, NKT cells and liver inflammation
Albert Bendelac, Chicago

5:20-5:40 Discussion

END DAY 2

DAY3: Sun, Jan 27, 2008

Session VII. Autoimmunity and the Liver

8:30-8:50 Autoimmune disease in the liver: Molecular mechanisms and pathological pictures
Diego Vergani, London

8:50-9:10 Development of regulatory T cells in health and disease
Anjana Rao, Harvard (IB)

9:10-9:30 Immunomics of autoimmune liver disease: Relationship with other autoimmune diseases
Michael Manns, Hannover

9:30-9:50 Antigen presentation to T regulatory cells
Kayo Inaba, Kyoto (IB)

9:50-10:10   CD4+ T cells, TGF-b, and autoimmune liver disease
Jim Gorham, Lebanon, New Hampshire

10:10-10:30 Destruction of Dock2 gene prevents development of autoimmune disease and allograft rejection
Takehiko Sasazuki, Tokyo (IB)

10:30-10:50 Autoimmune driven pathological mechanisms in the liver: lessons from animal models
Eric Gershwin, Davis

10:50-11:20 Discussion

Closing Session

11:20-12:00 Debate of the Hypotheses
Conference Organizers

12:00   Adjourn