Publications/Grants/Projects

Peer-reviewed Publications

  • Hochman DJ, Collaco CR, Brooks EG. Acrolein induction of oxidative stress and degranulation in mast cells. Environ Toxicol. 2012 Oct 10. doi: 0.1002/tox.21818. [Epub ahead of print] PMID: 23047665
  • Hallberg LM, Ward JB, Hernandez C, Ameredes BT, Wickliffe JK. Advanced Collaborative Emissions Study (ACES) Subchronic exposure results: biologic responses in rats and mice and assessment of genotoxicity. Part 3. Assessment of genotoxicity and oxidative stress after exposure to diesel exhaust from U.S. 2007-compliant diesel engines: Report on 1- and 3-month exposures in the ACES bioassay. Res Rep Health Eff Inst., (166): 163-184, 2012.
  • Heung M. Lee, Lance M. Hallberg, George H. Greeley, Jr. and Ella W. Englander,. Differential Inhibition of Mitochondrial Respiratory complexes by Inhalation of Combustion Smoke and Carbon Monoxide, Invivo, in Rat Brain, Inhalation Toxicology Aug. 20, 22(9), 770-777, 2010
  • Castro SM, Kolli D, Guerrero-Plata A, Garofalo RP, Casola A. Cigarette smoke condensate enhances respiratory syncytial virus-induced chemokine release by modulating NF-kappa B and interferon regulatory factor activation.Toxicol Sci 2008 Dec,106(2):509-18. doi: 10.1093/toxsci/kfn175. Epub 2008 Aug 22. PMID: 18723827
  • Wickliffe JK, SM Herring, LM Hallberg, LA Galbert, OE Masters III, M M Ammenheuser, J Xie, EC Friedberg, RS Lloyd, SZ Abdel-Rahman, JB Ward, Jr. Detoxification of olefinic epoxides and nucleotide excision repair of epoxide-mediated DNA damage: insights from animal models examining human sensitivity to 1,3-butadiene. Chemico-Biological Interactions, 166, 226-231, 2007.
  • Wickliffe JK, Galbert LA, Ammenheuser MM, Herring SM, Xie J, Masters OE, III, Friedberg EC, Lloyd RS, Ward JB, Jr. 3,4-Epoxy-1-butene, a reactive metabolite of 1,3-butadiene, induces somatic mutations in Xpc-null mice, Environ Mol Mutagen. 67-70, 2006.
  • Abdel-Rahman SZ, Ammenheuser MM, Omiecinski CJ, Wickliffe JK, Rosenblatt JI, Ward JB Jr. Variability in human sensitivity to 1,3-butadiene: influence of polymorphisms in the 5'-flanking region of the microsomal epoxide hydrolase gene (EPHX1).Toxicol Sci. 2005 May;85(1):624-31. Epub 2005 Feb 16.PMID: 15716486
  • Wickliffe JK, Ammenheuser MM, Salazar JJ, Abdel-Rahman SZ, Hastings-Smith DA, Postlethwait EM, Lloyd RS, Ward JB. A model of sensitivity: 1,3-Butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene. Environ Mol Mutagen. 106-110, 2003.

Abstracts

  • Hallberg LM, Parks JL, Hernandez CL, Norton CM, Ward JB, Ameredes BT, Wickliffe JK. Biomarker-based Evaluation of Diesel Exhaust Emissions from 2007-Compliant Engines in Rats and Mice Exposed for Defined Time Periods. Society of Toxicology Annual Meeting San Antonio, Texas, Toxicologist 132(1) 399, 2013.
  • Hallberg LM, Parks J, Hernandez C, Ward JB, Ameredes BT, Norton C, Zaas S, and Wickliffe JK. ACES: Genotoxicity of Diesel Exhaust from 2007-Compliant Diesel Engines: A Continuation of the Study, Health Effects Institute Annual Meeting San Francisco, California 32, 2013.
  • Reno AL, Hallberg LM, Spear WC, Parks JL, Chaparro AP, Brooks EG, Ameredes BT. Sulfur dioxide modulates oxidative stress responses in IL-10 deficient mice with airway inflammation. Society of Toxicology Annual Meeting San Antonio, Texas, Toxicologist 132(1) 431, 2013.
  • Hallberg LM, Ward JB, Ameredes BT, Wickliffe JK. Assessment of the Genotoxicity of Diesel Exhaust Particulates from Improved Diesel Engines. Health Effects Institute Annual Meeting Chicago, Illinois 36, 2012.
  • Reno AL, Hallberg LM, Spear WC, Parks JL, Principe MF, Brooks EG, Ameredes BT. Sulfur dioxide promotes a pro-oxidant shift in IL-10-deficient mice with airway inflammation. The Toxicologist Vol. 126 (1), 2012.
  • Ruiz J, Hallberg LM, Panettieri, Jr. RA, Ameredes BT. Involvement of the mitochondrial respiratory chain in the anti-inflammatory effects of carbon monoxide in human airway smooth muscle cells. Am. J. Resp. Crit. Care Med. Vol. 185: A1277, 2012.
  • Hallberg LM, Parks JL, Hernandez CL, Norton CM, Ward JB, Ameredes BT, Wickliffe JK. Genotoxicity of diesel exhaust from 2007-compliant diesel engines: a continuation of the ACES study Health Effects Institute Annual Meeting Boston, Massachusetts, 2011.
  • Ruiz J, Hallberg LM, Parks JL, Panettieri RA, Boldogh I, Ameredes BT. Reduction of intracellular ROS levels and oxidative metabolic activity in human airway smooth muscle cells by carbon monoxide and hypoxia. Am. J. Resp. Crit. Care Med. Vol. 183: A2538, 2011.
  • Reno AL, Hallberg LM, Parks JL, Calhoun WJ, Ameredes BT. Modulatory effects of sulfur dioxide on the production of nitric oxide in murine airway inflammation. Am. J. Resp. Crit. Care Med. Vol. 183: A1423, 2011.
  • Ruiz, J, Duru EA, Parks JL, Panettieri RA, Calhoun WJ, Ameredes BT. Reduction of GM-CSF release in human airway smooth muscle cells by carbon monoxide, hypoxia, and anoxia. Am J Respir Crit Care Med Vol. 181:A3597, 2010.
  • Thompson M, Shilpi G, LM Hallberg, JB Ward, JA Swenberg, G Boysen. Effects of styrene co-exposure on formation of 1,3-butadiene derived N7-guanine adducts. Society of Toxicology Annual Meeting Salt Lake City, Utah, Toxicologist 114(1) 400, 2010.
  • Reno AL, Duru EA, Parks IV JL, Aloi FP, Choi AMK, Calhoun WJ, Ameredes BT. IL-12p40 subunit expression in lungs of mice administered low-dose carbon monoxide. Am. J. Resp. Crit. Care Med. 179: A5448, 2009.
  • Ruiz J, Duru EA, Parks IV JL., Panetierri RA, Calhoun AJ, Ameredes BT. Reduction of GM-CSF release in human airway smooth muscle cells by carbon monoxide and hypoxia. Am. J. Resp. Crit. Care Med. 179: A3170, 2009.

Grants/Contract Projects/Project and Program Affiliations

  • NIEHS/UTMB: Cellular Response Mechanisms to Environmental Challenge, Center in Environmental Toxicology (5P30ES006676: 2012-2017)
  • Alcon Research, Inc.: Effects of Novel Compounds on Nasal Sinus Inflammation (2010-2013)
  • Health Effects Institute: Assessment of Genotoxicity of Diesel Exhaust/Particulates from Improved Diesel Engines. (2010-2013)
  • NIEHS/Univ. North Carolina: Adducts as quantitative markers of butadiene mutagenesis: Inhalation exposure to 1, 3-butadiene. (NIEHS 1R01ES012689 ; 2009-2012)
  • NIEHS/CET/UTMB: Role of IL-10 in SO2-exacerbated Asthma (5P30ES006676: Pilot Project: 2009-2011)
  • NIEHS/UTMB: Molecular Mechanisms for Environmental Injury (05T32ES007254-20: 1990-2016)
  • Sealy Center for Environmental Health and Medicine (SCEHM)/UTMB
  • The Brown Foundation