John Sealy Distinguished Chair for MD-PhD Studies Professor of Internal Medicine Professor of Neuroscience and Cell Biology A.B., Harvard College, 1977 M.D., Ph.D., Washington University, 1984 Postdoctoral, Digestive Diseases, Yale University American Digestive Health Foundation Basic Science Research Award American Gastroenterological Association Research Scholar

Pathogenesis of Viral and Alcoholic Hepatitis Role of Mitochondria in Liver Diseases

Okuda, M.; Li, K.; Beard, M.R.; Showalter, L.A.; Scholle, F.; Lemon, S.M.; Weinman, S.A. Mitochondrial injury, oxidative stress and antioxidant gene expression are induced by hepatitis C virus core protein. Gastroenterology 122:366-375, 2002. Wang, T.; Weinman, S.A. Involvement of chloride channels in hepatic copper metabolism: ClC-4 promotes formation of holoceruloplasmin. Gastroenterology. 126:1157-1168, 2004. Korenaga, M., Wang, T., Li, Y., Showalter, L., Chan, T., Sun, J., Weinman, S.A. Hepatitis C Virus Core Protein inhibits mitochondrial electron transport and increases ROS production. J.Biol Chem, 280:45-37841, 2005. Otani, K., Korenaga, M., Beard, M.R., Li, K., Qian, T., Showalter, L.A., Singh, A.W., Wang, T., Weinman, S.A. Hepatitis C virus core protein, cytochrome P450 2E1, and alcohol produce combined mitochondrial injury and cytotoxicity in hepatoma cells. Gastroenterology, 128:96-117, 2005. Loo, YM., Owen, DM., Li, K., Erickson, AK., Johnson, CL., Fish, CL., Carney, DS., Wang, T., Ishida, H., Yoneyama, M., Fujita, T., Satio, T., Lee, WM., Hagedorn, CH., Lau, DT., Weinman, SA., Lemon, SM., Gale, M, Jr.Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection. Proc Natl Acad Sci USA, 103:6001-6006, 2006. Wang, T., Weinman, S.A., Causes and consequences of mitochondrial reactive oxygen species generation in Hepatitis C. J Gastroenterol Hepatol, 3:S34-7, 2006 Chen, Z., Benureau, Y., Rijnbrand, R., Yi, J., Wang, T., Warter, L., Lanford, R.E., Weinman, S.A., Lemon, S.M., Martin, A., Li, K. GB virus B disrupts RIG-I signaling by NS3/4A-meditated cleavage of the adaptor protein MAVS. J. Virol, 81:964-976, 2007 Li, Y., Boehning, D., Qian, T., Popov, V., Weinman, S.A. Hepatitis C virus core protein increases mitochondrial ROS production by stimulation of Ca2+ uniporter activity. FASEB Journal, 21:2474-85, 2007 Zhao, Z., Li, X., Hao, J., Winston, J., Weinman, S.A. The CIC-3 chloride transport protein traffics through the plasma membrane via interaction of an N-terminal dileucine cluster with clathrin. J. Biol. Chem, 282:29022-29031, 2007

Clinical Interests General Hepatology Viral Hepatitis

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