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Sutapa Ray, Ph.D.
Assistant Professor

Sutapa Ray, Ph.D.

Sutapa Ray, Ph.D.
Assistant Professor
Division of Endocrinology
Department of Internal Medicine

University of Texas Medical Branch
8.138 Medical Research Building
Galveston, TX 77555-1060
Phone: 409.772.1922
Fax: 409.772.8709

Personal Overview

My research interest is to investigate the role of IL-6-JAK-STAT3 signaling pathway in inflammation and acute phase response, mainly focusing on the regulation of Signal Transducer and Activator of Transcription-3 (STAT3) by post translational modification. STAT3 is a latent transcription factor activated by tyrosine and serine phosphorylation in response to many cytokines and growth factors. Earlier we discovered that interleukin-6 induces acetylation of the STAT3 NH2-terminus by the recruitment of the p300 coactivator and is essential for target gene activation and chromatin remodeling. We subsequently showed that acetylation of STAT3 at its NH2 terminus is also required for binding of other important transcriptional regulators e.g. P300, PTEFb complex, HDAC1 and APE1. My long term goal is to investigate the role of IL-6-STAT3 pathway in tissue regeneration and cellular proliferation in burn-induced hypertrophic scarring. Elucidating this pathway should demonstrate a role of STAT3 antagonists to be used as therapeutic interventions in the treatment of post burn inflammation and morbidity.

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