Tapas Hazra, PhD
Associate Professor, Division of Pulmonary Critical Care & Sleep Medicine
Tapas Hazra, PhD
Associate Professor, Department of Internal Medicine and
Department of Biochemistry and Molecular Biology
Scientist, Sealy Center for Molecular Medicine
Division of Pulmonary Critical Care & Sleep Medicine
University of Texas Medical Branch
301 University Blvd.
Galveston, TX 77555-1079
|Degree/Training Completed||Year||Name & Location|
|B.Sc Chemistry||1982||Calcutta University, India|
|M.Sc Biochemistry||1985||Calcutta University, India|
|Ph.D Biochemistry||1992||Jadavpur University, India|
- Oxidative damage repair in mammalian genomes
- Enzyme kinetics, biochemical and cellular characterization of protein-protein and protein-DNA interactions
- Post-translational modification of DNA repair proteins, SNP analysis, mutation analysis, transcription-coupled repair of oxidized bases, DNA repair and inflammation: linkage to disease susceptibility.
- Hazra, TK; Izumi, T.; Boldogh, I.; Imhoff, B.; Kow, Y. W.; Jaruga, P., Dizdaroglu, M. and Mitra S. Identification and characterization of a human DNA glycosylase for repair in modified bases in oxidatively damaged DNA. Proc. Natl. Acad. Sci. 99:3523-3528, 2002. PMID: 11904416
- Hazra, TK, Kow, Y. W., Hatahet, Z., Imhoff, B., Boldogh, I., Mokkapati, S. K., Mitra, S., and Izumi, T. Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived bases. J. Biol. Chem. 277:30417-30420, 2002. PMID: 12097317.
- Dou H, Mitra S, Hazra TK.: Repair of oxidized bases from DNA bubble structures by human DNA glycosylases NEIL1 and NEIL2. J. Biol. Chem. 278:49679-49684, 2003. PMID: 14522990
- Das A, Wiederhold L, Leppard JB, Kedar P, Prasad R, Wang H, Boldogh I, Karimi-Busheri F, Weinfeld M, Tomkinson AE, Wilson SH, Mitra S, Hazra TK: NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for repair complex in human cell." DNA Repair. 5: 1439-48. 2006. PMID: 16982218 PMCID: PMC2805168
- Banerjee D, Mandal SM, Das A, Hegde ML, Das S, Bhakat KK, Boldogh I, Sarkar PS, Mitra S, Hazra TK: Preferential repair of oxidized base damage in the transcribed genes of mammalian cells." J Biol Chem. 2010 Dec 17. [Epub ahead of print] PMID: 21169365
The department of internal medicine is developing evidence based clinical protocols which will be available in EPIC (as order sets) for use when admitting patients with these diagnoses. Their AIM is to standardize care and decrease length of stay and readmission rates.Currently available protocols are:
- CAP - Community Acquired Pneumonia Orderset
- Congestive Heart Failure (CHF)
- Chronic Obstructive Pulmonary Disease (COPD)
- Diabetic Ketoacidosis Adult, ICU
- General Medicine Admission
- Immunodeficiency Flow Panel
- MICU/CCU Admission Order Set
- Oral Analgesic Medicaitons
- Parenteral Opioids
- Sepsis, Adult ICU
- 111 - Stroke Alert
- 112 - Stroke Activation
- 300086 - Stroke Floor Admission
- 3000000001 - Stroke Critical care without tPA
- 300088 Stroke - Transfer from Critical care to floor
- 3004002 - Stroke Discharge
All protocols can be found in the EPIC order set section.
The department of Internal Medicine has a large role in the Meaningful Use Initiative. Our participation is key for the success of the initiative. Please visit the meaningful use website for important communication and updates from the Meaningful Use Initiative.