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AMITRIPTYLINE, serum (087-0460) Synonyms: Elavil CPT 4 Code: 80152 Test Order Mnemonic: AMITRIP Test Includes: Nortriptyline Lab: Clinical Chemistry Request Form: Special Chemistry Form 2 Collection: Routine venipuncture. The optimum time for collection of blood specimen is between 10 and 14 hours after the last dose of medication for patients taking antidepressants once a day and just before the morning dose for patients who are on a divided dose schedule. Lab slip request must include date and time of specimen collection. Storage Instructions: Process as soon as possible. Serum must be removed from the clot within 4 hours of draw and frozen. Causes for Rejection: Serum not separated from the clot in 4 hours or less, blood collected with plasticizers or gel separators Availability: Samples are received 24 hrs per day at Sample Management, Room 5.136 McCullough. Turnaround Time: Routine: 3-5 days; test is performed on Tuesdays and Thursdays. Special Instructions: Cyclobenzaprine (Flexeril) interferes with the quantitation of amitriptyline; therefore, amitriptyline cannot be quantitated if the patient is also on cyclobenzaprine. Some of the phenothiazines may also interfere. Specimen: Blood Volume: 7 mL blood Minimum Volume: 1 mL serum Container: Red-topped tube. Do not use SST/gel separator tube. Reference Ranges: Therapeutic Range: 80-200 ng/mL (Total) Critical Values: Potential Toxicity: > 500 ng/mL (Total) Test Method: HPLC Revised April 2007 by P. Harris |
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