IMIPRAMINE

Collection: Routine venipuncture. The optimal time for collection of specimens for steady-date levels is between 10 and 14 hours after the last dose of medication for patients taking antidepressants once a day, and just before the morning dose for patients who are on a divided dose schedule.

Storage Instructions: Store at 2-8°C. Centrifuge the specimen and remove the serum from the red cells within 4 hours of collection; freeze serum in plastic vial at -20°C.

Causes for Rejection: Serum allowed to remain on the clot for more than 4 hours, blood collected in a SST tube

Availability: Samples are received 24 hours per day at Sample Management, 5.136 McCullough.

Turnaround Time: Routine: 3-5 days; test is performed on Tuesdays and Thursdays

Specimen: Blood

Volume: 7 mL blood

Minimum Volume: 1 mL serum

Container: Red-topped tube. Do not use SST tubes.

Reference Ranges: Therapeutic Range: Imipramine, 150-300 ng/mL; Desipramine, 150-300 ng/mL

Critical Values: Potential Toxicity: > 500 ng/mL

Test Method: HPLC

Reviewed/revised April 2007 by P. Harris

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