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NORTRIPYLINE, serum (087-0668)
Test Mnemonic:

  NORTRIP
Methodology:

 UHPLC/MS/MS
Performed:

 Clinical Chemistry
Turnaround Time:

 Routine: 3-5 days; test is performed Tuesdays and Thursdays
Specimen Requirements:

Collect: Routine venipuncture. The optimal time for collection of specimens for steady-date levels is between 10 and 14 hours after the last dose of medication for patients taking antidepressants once a day, and just before the morning dose for patients who are on a divided dose schedule. Red-topped tube. Do not use SST/serum separator tubes.

Storage/Transport: Store at 2-8°C. Centrifuge the specimen, remove serum from red cells within 4 hours of collection and freeze in a plastic vial.

Causes for Rejection: Serum allowed to remain on the clot for more than 4 hours, blood collected in a SST/serum separator tube
Clinical Information:

If applicable, state clinical information that is required to be provided with specimen.
Reference Range:

By report (reports may vary based on instrumentation, patient age and sex)
Note:

 Blood samples received in the TDM laboratory before noon on the day of analysis will be included on the run. STAT requests after 4:00 PM require the approval of the director or pathology resident on call. Metabolites of cyclobenzaprine (Flexeril) may cause interference. Nortriptyline cannot be quantitated if the patient is also on cyclobenzaprine. Some of the phenothiazines may also interfere.
CPT 4 Code:

  80182
7/13/12 Reviewed by Tho Nguyen, MT(ASCP)

When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient.  Components of the organ or disease panels may be ordered individually.  The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-9 code or its verbal equivalent.

  

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