Laboratory Test Directory

Prothrombin Time: (089-0106)

Useful in monitoring Warfarin/Coumadin therapy and detecting abnormalities of the extrinsic clotting pathway.

 PT

 Electromagnetic Viscosity Detection

 Samples are accepted 24 hours per day at Sample Management, 5.136 McCullough Bldg.

 STAT: 1 hour; ROUTINE: 4 hours

Collect: Routine venipuncture; discard 1st mL of blood or collect other tubes (EDTA, red-topped) prior to collecting sample in blue-topped (3.2% sodium-citrate) tube.

Specimen Preparation:  Samples drawn for Prothrombin Time testing should be stored and transported at ROOM TEMPERATURE to avoid activation of Factor VII. Deliver sample to lab within ½ hour for best results.

Specimen: Blood

Volume:  2.7 ml

Minimum Volume:  Call Lab

Storage/Transport:  NOTE:  If time from draw to receipt in the laboratory is to be greater than 24 hours, centrifuge the specimen for 15 minutes at 2000-2500g.  Remove the plasma from red cells and snap freeze (-20°C) plasma.

Stability: Unrefrigerated whole blood samples are viable for 24 hours. Plasma may be stored at 20+/- 5°C for  8 hours. Snap frozen plasma is viable for 6 months.

Causes for Rejection: QNS, clotted, severely hemolyzed specimen, specimen greater than 24 hours old, wrong tube (3.8% sodium citrate), high hematocrit (> 55%), identification error, sample processed/transported, and/or stored improperly.

Therapeutic Range:  Using the INR: Standardization of the Prothrombin Time (PT) with the International Normalized Ratio (INR) allows for uniform measurement of the anticoagulation status of patients on oral anticoagulants (Warfarin/Coumadin/Coumarin).  The use of the INR has permitted development of effective recommendations for use of oral anticoagulants in a variety of clinical settings.  Most published studies indicate that in most cases an INR of at least 2.0 is required for effective anticoagulation.  The risk of bleeding increases with an increasing INR, and may increase dramatically above an INR of 4.5 - 5.0.   Refer to Monitoring Oral Anticoagulant Therapy or contact laboratory [409-772-3314] for further recommendations.

Critical Values:  PT > 42.1 seconds

Interfering Substances: Heparin above therapeutic ranges, afibrinogenemia or hypofibrinogenemia

12.0 – 14.7 seconds

 85610  Limited Coverage Test (NCD)

When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient.  Components of the organ or disease panels may be ordered individually.  The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-9 code or its verbal equivalent.

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