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Cryptococcus antigen test: (088-0451)

Clinical Indication:

 Screening test for the detection of Cryptococcus neoformans antigen in serum and CSF.

Test Mnemonic:

 F CRY

Methodology:

Enzyme immunoassay - Meridian

Performed:

 Clinical Microbiology

Turnaround Time:

 Test is performed daily

Specimen Requirements:

Collect: Submit at least 0.5 ml of CSF. Collect serum in gold topped (SST) tube

Specimen Preparation: None for CSF; centrifuge SST tube

Storage/Transport:  Refrigerate

Stability: 48 hours

Causes for Rejection:  Insufficient quantity, hemolysis, lipemia

Clinical Information:

A positive result is considered to be a critical value and the LIP is notified, first occurrence only.

This test replaces the India ink prep to detect Cryptococcus in CSF.

Reference Range:

Negative

Note:

CSF and serum samples that are positive by screening test are submitted to a reference laboratory for antigen titer.

CPT 4 Code:

 87327

Review 9/17/2012 by T. Friloux

When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient.  Components of the organ or disease panels may be ordered individually.  The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-9 code or its verbal equivalent.

 

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