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SYPHILIS IGG SCREEN (088-0236)
Clinical Indication:

 Infection with Treponema pallidium, primary, secondary or tertiary syphilis diseases.
Test Mnemonic:

 SYPG
Methodology:

 Multiplex immunoassay, RPR, TP-PA
Performed:

 Clinical Microbiology
Turnaround Time:

 Test is performed daily, Monday through Friday
Specimen Requirements: Patient Preparation: Routine venipuncture

Collect: SST (Serum separator tube)

Specimen Preparation: Let sample fully clot, then centrifuge

Storage/Transport: Refrigerate 2-80C; indefinitely frozen

Stability: 7 days, refrigerated

Causes for Rejection: Insufficient quantity, gross hemolysis, lipemia, specimen container unlabeled or labeled incorrectly. No date and time of collection on requisition form.
Clinical Information:

All samples are screened with the Syphilis IgG  test. If the screening test is positive or indeterminate, RPR titer and confirmation test (TP-PA) are performed.

RPR titer is performed on previously positive patients samples, but confirmation is not required. If following a positive patient and need RPR titers only, request RPR QUANT Test
Reference Range:

Negative or Non-reactive
Note:

Guidelines for testing patient samples: 

For patients diagnosed with syphilis (i.e., positive IgG and confirmatory test), the CDC recommends that response to therapy be assessed by testing the RPR (looking for a 4-fold decline in titer) after 6 months. Exception: Specimens from Labor and Delivery are tested if seven days have elapsed since the last test.

Tests are performed on all obstetrics patients regardless of previous results.  If there is no previous patient data, the requested tests are performed.

VDRL test is performed on CSF samples as a Sendout test for patients with positive serum test results, only.
CPT 4 Code:

 86780, 86753: RPR
Review 2/13/2013 by Theresa Friloux

When ordering tests for which Medicare or Medicaid reimbursement will be sought, physicians should only order tests that are medically necessary for the diagnosis or treatment of the patient.  Components of the organ or disease panels may be ordered individually.  The diagnostic information must substantiate all tests ordered and must be in the form of an ICD-9 code or its verbal equivalent.

 

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