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Current MD-PhD Student - James Sowers

Name: James Sowers

Year in Program: MY1

Undergrad University: Johns Hopkins Univeristy

Mentor: TBD

Graduate Program: TBD


    Research Interests

  • Developing mass spectrometry-based assays to follow epigenetic reprogramming in glioblastoma stem cells and human neural stem cells (hNSC) and to measure metabolic changes resulting from tissue damage and inflammation.
  • To better understand the pathophysiology of neurodegeneration due to disease or trauma and ultimately to develop better strategies for treating patients with neurodegenerative disorders.

    Honors & Awards

  • Graduated with University Honors, Johns Hopkins University (2013)
  • Graduated with Departmental Honors in Chemistry, Johns Hopkins University (2013)
  • Dean's List (2009-2013)
  • Golden Key Society


  • Sowers, J. L., Johnson K. M., Conrad C., Patterson J. T., Sowers, L.C. (2014) "The Role of Inflammation in Brain Cancer" Adv. Exp. Med. Biol. 816, 75-105.
  • Darwanto, A., Theruvathu, J. A., Sowers, J. L., Rogstad, D. K., Pascal, T., Goddard, WA III, and Sowers, L. C. (2009) Mechanism of base selection by single-stranded selective monofunctional uracil-DNA glycosylase. J. Biol. Chem. 284, 15835-46.


  • James L. Sowers, Jason L. Herring, Ping Wu, Lawrence C. Sowers. "Epigenetic Reprogramming in Human Neural Stem Cells" at UT Austin MD/PhD Symposium.

    Hobbies or just something about yourself in general:

Career Development

The career development of an MD-PhD student is critically important and extends out well past the date of graduation with the dual degrees. The UTMB MD-PhD Program carefully guides and nurtures students throughout the Program. Early in the Program, critical issues are mentor selection and choice of a graduate program. MD-PhD students meet regularly with a faculty advisor, a student "big sibling" and members of the advisory committee. Opportunities to be exposed to research opportunities are provided through Program activities as well as the scientific activities on campus. Most students do their initial laboratory rotation during the summer before starting medical school. Additional laboratory rotations can be completed during the summer before the first and second years of medical school and after the second year of medical school. Once students are established in their labs, they are guided through their research by a mentor and dissertation committee.

For MD-PhD students, selection of the dissertation committee is essential and our Program requires students to include a member who is an MD scientist who can provide guidance on career progress and residency selections. As thesis defense approaches, students design their optimal clinical experiences with members of the MD-PhD committee to maximize chances to obtain the types of residency training that will be most compatible with further development as a physician scientist. The Program runs career guidance seminars to alert students to many of the important issues, pitfalls and milestones that they will need to navigate in the future. These include the pros and cons of short-track residencies, the need for additional postdoctoral training, and how to select and negotiate a first faculty appointment. The UTMB MD-PhD graduate is thus well positioned to make the most out of the advantages that MD-PhD careers offer.