Current MD-PhD Student - Pat Gulhati
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Name: Pat Gulhati
Year in Program: MY4
Undergrad University: University of British Columbia
Mentor: B. Mark Evers, M.D.
Graduate Program: Cell Biology |
Research Interests
Novel therapies for metastatic colorectal cancer
Honors and Awards
- Katherine Siebert Award for Excellence in Oncology Research, University of Texas Medical Branch, Galveston, TX (2012)
- Kay and Cary W. Cooper Scholarship Award, University of Texas Medical Branch, Galveston, TX (2012)
- Robert Harrison M.D. Memorial MD/PhD Scholarship, University of Texas Medical Branch, Galveston, TX (2010)
- Margaret Saunders Travel Award, University of Texas Medical Branch, Galveston, TX (2010)
- Scholar-in-Training Award, American Association for Cancer Research, San Francisco, CA (2010)
- Poster of Distinction at Digestive Diseases Week, American Gastroenterological Association, New Orleans, LA (2010)
- Shirley Patricia Parker Oncology Scholarship, University of Texas Medical Branch, Galveston TX (2009)
- Cancer Day Student Poster Presentation Award, University of Texas Medical Branch, Galveston, TX (2009)
- Osler Award in Translational Medicine, National Student Research Forum, Galveston, TX (2009)
- Sealy Center for Cancer Biology Pre-Doctoral Fellowship Award, University of Texas Medical Branch, Galveston TX (2008)
- MD/PhD Fellowship Award, University of Texas Medical Branch, Galveston TX (2006-Present)
- British Columbia Cancer Studentship Award, Canadian Breast Cancer Foundation and BC Cancer Agency, Vancouver BC, Canada (2006)
- Summer Academic Scholarship, University of British Columbia, Vancouver BC, Canada (2005)
- Faculty of Medicine Summer Research Studentship, University of British Columbia, Vancouver BC, Canada (2005)
- Dean's Honor List, University of British Columbia, Vancouver BC, Canada (2003-2005)
- Golden Key Honor Society Nomination (2003-2005)
- Undergraduate Academic Scholarship, University of British Columbia, Vancouver BC, Canada (2002-2005)
- Undergraduate Entrance Scholarship, Government of British Columbia & University of British Columbia, Vancouver BC, Canada (2002)
Publications:
- Gulhati P, Bowen KA, Liu J, Stevens PD, Rychahou PG, Chen M, Lee EY, Weiss HL, O'Connor KL, Gao T and Evers BM. mTORC1 and mTORC2 regulate motility, EMT and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Research. 2011. 71(9): 3246-3256.
- Gulhati P, Cai Q, Li J, Liu J, Rychahou PG, Qiu S, Lee EY, Silva SR, Bowen K, Gao T and Evers BM. Targeted inhibition of mTOR signaling inhibits tumorigenesis of colorectal cancer. Clinical Cancer Research. 2009. 15(23): 7207-16.
- Gulhati P, Zaytseva YY, Valentino JD, Stevens PD, Kim JT, Sasazuki T, Shirasawa S, Lee EY, Weiss HL, Dong J, Gao T and Evers BM. Sorafenib enhances the therapeutic efficacy of rapamycin against colorectal cancers harboring oncogenic K-RAS and PIK3CA. Carcinogenesis. 2012. 33(9):1782-90.
- Johnson SM*, Gulhati P*, Arrieta I, Wang X, Gao T and Evers BM. Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling. Anticancer Research. 2009.29: 3185-3190. (*authors contributed equally)
- Gulhati P, Kopetz S. K-RAS mutation is associated with development of lung metastases in colorectal cancer. In Preparation
- Wang X, Gulhati P, Li J, Dobner PR, Weiss HL, Townsend CM and Evers BM. Characterization of promoter elements regulating expression of the human neurotensin/neuromedin N gene. Journal of Biological Chemistry. 2011. 286(1): 542-554.
- Johnson SM, Gulhati P, Rampy BA, Han Y, Rychahou PG, Doan HQ, Weiss HL and Evers BM. Novel expression patterns of PI3K/AKT/mTOR signaling pathway components in colorectal cancer. Journal of American College of Surgeons. 2010. 210(5): 767-776.
- Rychahou PG, Kang J, Gulhati P, Doan HQ, Chen LA, Xiao SY, Chung DH and Evers BM. Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis. Proceedings of the National Academy of Sciences USA. 2008. 105(51): 20315-20.
- Bowen KA, Silva SR, Johnson JN, Doan HQ, Jackson LN, Gulhati P, Qiu S, Riall TS, Evers BM. An Analysis of Trends and Growth Factor Receptor Expression of GI Carcinoid Tumors. J. Gastrointestinal Surgery. 2009. 13(10): 1773-80.
- Zaytseva YY, Valentino JD, Gulhati P and Evers BM. mTOR inhibitors in cancer therapy. Cancer Letters. 2012. 319(1): 1-7.
- Zaytseva YY, Rychahou PG, Gulhati P, Elliott VA, Mustain WC, O'Connor KL, Morris AJ, Sunkara M, Weiss HL, Lee EY and Evers BM. Inhibition of Fatty Acid Synthase Attenuates CD44-associated Signaling and Reduces Metastasis in Colorectal Cancer. Cancer Research. 2012. 72(6):
1504-17.
- Li X, Stevens PD, Yang H, Gulhati P, Wang W, Evers BM and Gao T. The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer. Oncogene. 2012. In Press
- Kim JT, Li J, Jang ER, Gulhati P, Rychahou PG, Townsend CM, Liu C and Evers BM. The Wnt signaling pathway is deregulated in human neuroendocrine tumor cells by mutation or epigenetic silencing of Wnt inhibitor genes. Submitted to Cancer Research
Presentations:
- Gulhati P, Bowen K, Liu J, Stevens P, Rychahou P, Chen M, Lee E, Weiss H, O'Connor K, Gao T and Evers BM. mTORC1 and mTORC2 regulate EMT, motility and metastasis of colorectal cancer via RhoA and Rac1 signaling. Presented at 'Digestive Diseases Week', Chicago, Illinois, May 7-May 10,
2011.
- Gulhati P, Zaytseva Y, Weiss H, Gao T, Dong J and Evers BM. Combination of rapamycin with sorafenib as a therapeutic strategy against colorectal cancers with mutational activation of KRAS and PIK3CA. Presented at 'American Association for Cancer Research 102nd Annual Meeting', Orlando,
Florida, April 2-6, 2011.
- Gulhati P, Bowen K, Liu J, Stevens P, Rychahou P, Chen M, Lee E, Weiss H, O'Connor K, Gao T and Evers BM. mTORC1 and mTORC2 regulate motility and metastasis of colorectal cancer via RhoA and Rac1 signaling. Presented at 'AACR: Targeting PI3K/mTOR Signaling in Cancer 2011', San
Francisco, California, February 24-February 27, 2011.
- Gulhati P, Zaytseva Y, Bowen K, Weiss H, Gao T, Dong J and Evers BM. Combined Inhibition of mTOR and MAPK Signaling Attenuates the Growth and Progression of Colorectal Cancer. Presented at 'AACR: Translational Cancer Medicine 2010', San Francisco, California, July 11-July 14, 2010.
- Gulhati P, Bowen K, Gao T, Dong J and Evers BM. Dual Inhibition of mTOR and MAPK Signaling Attenuates the Growth and Progression of Colorectal Cancer. Presented at 'Digestive Diseases Week', New Orleans, Louisiana, May 1-May 5, 2010.
- Gulhati P, Bowen K, Liu J, Li J, Qiu S, Weiss HL, Gao T and Evers BM. Targeted inhibition of the mTOR complex components, Raptor and Rictor, attenuates progression of colorectal cancer. Presented at 'American Association for Cancer Research 101st Annual Meeting', Washington, District
of Columbia, April 17-21, 2010.
- Targeted inhibition of mTOR signaling inhibits tumorigenesis and metastasis of colorectal cancer.
'Markey Cancer Center Research Day', Lexington, Kentucky, April 14, 2010.
- Gulhati P, Cai Q, Bowen K, Li J, Liu J, Qiu S, Gao T and Evers BM. Targeted inhibition of mTOR signaling inhibits growth and progression of colorectal cancer. Presented at 'AACR: Frontiers in Basic Cancer Research', Boston, Massachusetts, October 8-11, 2009.
- Gulhati P, Li J, Dong J and Evers BM. Combined inhibition of mTOR and MAPK signaling inhibits growth, induces apoptosis, and prevents cell cycle progression in colorectal carcinoma. Presented at 'Digestive Diseases Week', Chicago, Illinois, May 30-June 4, 2009.
- Gulhati P, Cai Q, Li J, Liu J, Gao T, Qiu S and Evers BM. Effect of targeted inhibition of mTOR complexes on proliferation, apoptosis and cell cycle progression in colorectal carcinoma. Presented at 'National Student Research Forum', Galveston, Texas, April 23-25, 2009.
- Gulhati P, Cai Q, Li J, Liu J, Gao T, Qiu S and Evers BM. Effect of targeted inhibition of mTOR complexes on proliferation, apoptosis and cell cycle progression in colorectal carcinoma. Presented at 'American Association for Cancer Research 100th Annual Meeting', Denver, Colorado, April 18-22,
2009.
- Gulhati P and Herring FG. 'Rules' for Designing Effective Multimedia Presentations. Presented at the 'Gordon Research Conference – Visualization in Science and Education', Oxford, United Kingdom, July 3-8, 2005.
- Zaytseva YY, Rychahou PG, Gulhati P, Elliott VA, Mustain WC, O'Connor KL, Morris AJ, Sunkara M, Weiss HL, Lee EY and Evers BM. Inhibition of Fatty Acid Synthase Attenuates CD44-associated Signaling and Reduces Metastasis in Colorectal Cancer. Presented at 'Digestive Diseases Week', San Diego, California, May 19-May 22, 2012.
- Slone S, Gulhati P, Evers BM, Rinehart J and Weiss HL. Robustness of Modified Versions of the Continual Reassessment Method in Selecting a Phase I Trial Design. Presented at '31st Annual Meeting of the Society for Clinical Trials', Baltimore, Maryland, May 16-May 19, 2010.
- Wang XF, Gulhati P, Rychahou P, Silva S and Evers BM. Suppression of neurotensin receptor type 1 expression and function by apigenin in human colorectal cancers involves protein kinase CK2/JNK pathway. Presented at 'American Association for Cancer Research 101st Annual Meeting',
Washington, District of Coulmbia, April 17-21, 2010.
- Johnson SM, Gulhati P, Rampy BA, Han Y, Rychahou PG, Doan HQ, Weiss HL and Evers BM. Novel expression patterns of PI3K/AKT/mTOR signaling pathway components in colorectal cancer. Presented at 'Southern Surgical Association Annual Meeting', The Homestead, Hot Springs, Virginia,
December 6-9, 2009.
- Rychahou P, Gulhati P and Evers BM. RNAi-Mediated Selective Inhibition of PI3K/Akt Pathway Components. Presented at 'NCI Translational Science Meeting', Vienna, Virginia, November 5-7, 2009.
- Rychahou PG, Kang J, Gulhati P, Chen LA, Chung DH, Mark Evers. Akt2 is a critical regulator of colorectal cancer metastasis establishment. Presented at 'American Surgical Congress', Huntington Beach, California, February 12-15, 2008.
- Mifflin RC; DiMari J; Qiu S; Pinchuk IV; Saada JI; Gulhati P and Powell DW. Phenotypic Characterization of Human Myofibroblasts Isolated from Sporadic Colonic Adenocarcinomas. Presented at 'Digestive Diseases Week', Washington D.C., May 19-24, 2007.
- Powell DW, Mifflin R, DiMari J, Adegboyega P, Pinchuk I, Saada J, Gulhati P, Shao J and Sheng H. Role of myofibroblasts in colonic inflammation and cancer. Presented at the 'Stem Cells in Gastrointestinal Development, Regeneration and Neoplasia Conference', Tyson's Corner, Virginia,
September 8-9, 2006.
- Sorokin A, Anglesio M, Gulhati P, Ruzanov P, Sonenberg N, Ovchinnikov L, Sorensen PHB and Evdokimova V. Role of YB-1 in Cell Growth and Stress Response. Presented at the 'Seventh Conference on Signaling in Normal and Cancer Cells', Banff, Alberta, Canada, March 3-7, 2006.
Hobbies or just something about yourself in general:
I enjoy golf, soccer, tennis, and traveling.