Giulio Taglialatela, Ph.D.

Dr. Taglialatela received his doctorate degree in 1985 from the University of Rome "La Sapienza", Italy. After postdoctoral training at UTMB, he directed the laboratory of molecular and cell biology of the Sigma Tau Pharmaceutical Co. in Pomezia, Italy for three years, before returning to UTMB as a research-track assistant professor in the Dept. of Human Biological Chemistry and Genetics. In 1999 he accepted a tenure-track Assistant Professorship position offered by the Dept. of Anatomy & Neuroscience, where in 2002 he became Associate Professor and was awarded tenure status.

The main research interest of Dr. Taglialatela's group has focused for many years on the molecular mechanisms underlying neurodegenerative events occurring in the aged central nervous system, with particular regard to age-associated neurodegenerative diseases such as Alzheimer's Disease. In particular, Dr. Taglialatela's laboratory is concerned with determining the molecular consequence of neuroinflammation and oxidative stress on neuronal homeostasis and gene expression.

Within this general view, studies focus on apoptosis and perturbation of gene expression mediated by bcl-2 proteins imbalances consequent to free radical exposure and on selective neurotoxicity exerted by proinflammatory cytokines in neurotrophin-dependent neurons. The methods used are primarily molecular (DNA/RNA, gene expression) and biochemical (exogenous expression of mutant and modified proteins) applied to both in vitro and in vivo models.

Dr. Taglialatela's lab has trained several students and post docs. Currently the lab has two graduate students, one MD/PhD student, and one senior research associate and supported by government (NIA, NINDS), state (Texas ARP) and intramural (Sealy Fund for Biomedical Research) grants.

Recent Publications

Massaad CA, Portier B, Taglialatela, G (2004): Inhibition of transcription factor activity by nuclear compartment-associated Bcl-2. J Biol Chem 279 (52):54470-54478.
Christensen BN. Kochukov M. McNearney TA. Taglialatela G. Westlund KN.: Proton-sensing G protein-coupled receptor mobilizes calcium in human synovial cells. Am J Physiol Cell Physiol 289(3):C601-8, 2005
Thomas M.S., Zhang W.R., Jordan P.M., Saragovi H.U., Taglialatela G. (2005): Signaling pathways mediating a selective induction of nitric oxide synthase II by tumor necrosis factor alpha in nerve growth factor-responsive cells. J Neuroinflammation 2: 19.
Korenaga K, Micci MA, Taglialatela G, Pasricha J (2006): Suppression of nNOS expression in rat enteric neurones by the receptor for advanced glycation end-products. J Neurogastroent Motil, 18(5) 392-400.
Portier B, Ferrari D, Taglialatela G (2006): Rapid assay for quantitative measurement of apoptosis in cultured cells and brain tissue. J Neurosci Meth, in press.



Giulio Taglialatela, Ph.D. gtaglial@utmb.edu Dr. Taglialatela received his doctorate degree in 1985 from the University of Rome "La Sapienza", Italy. After postdoctoral training at UTMB, he directed the laboratory of molecular and cell biology of the Sigma Tau Pharmaceutical Co. in Pomezia, Italy for three years, before returning to UTMB as a research-track assistant professor in the Dept. of Human Biological Chemistry and Genetics. In 1999 he accepted a tenure-track Assistant Professorship position offered by the Dept. of Anatomy & Neuroscience, where in 2002 he became Associate Professor and was awarded tenure status. The main research interest of Dr. Taglialatela's group has focused for many years on the molecular mechanisms underlying neurodegenerative events occurring in the aged central nervous system, with particular regard to age-associated neurodegenerative diseases such as Alzheimer's Disease. In particular, Dr. Taglialatela's laboratory is concerned with determining the molecular consequence of neuroinflammation and oxidative stress on neuronal homeostasis and gene expression. Within this general view, studies focus on apoptosis and perturbation of gene expression mediated by bcl-2 proteins imbalances consequent to free radical exposure and on selective neurotoxicity exerted by proinflammatory cytokines in neurotrophin-dependent neurons. The methods used are primarily molecular (DNA/RNA, gene expression) and biochemical (exogenous expression of mutant and modified proteins) applied to both in vitro and in vivo models. Dr. Taglialatela's lab has trained several students and post docs. Currently the lab has two graduate students, one MD/PhD student, and one senior research associate and supported by government (NIA, NINDS), state (Texas ARP) and intramural (Sealy Fund for Biomedical Research) grants. Recent Publications Massaad CA, Portier B, Taglialatela, G (2004): Inhibition of transcription factor activity by nuclear compartment-associated Bcl-2. J Biol Chem 279 (52):54470-54478. Christensen BN. Kochukov M. McNearney TA. Taglialatela G. Westlund KN.: Proton-sensing G protein-coupled receptor mobilizes calcium in human synovial cells. Am J Physiol Cell Physiol 289(3):C601-8, 2005 Thomas M.S., Zhang W.R., Jordan P.M., Saragovi H.U., Taglialatela G. (2005): Signaling pathways mediating a selective induction of nitric oxide synthase II by tumor necrosis factor alpha in nerve growth factor-responsive cells. J Neuroinflammation 2: 19. Korenaga K, Micci MA, Taglialatela G, Pasricha J (2006): Suppression of nNOS expression in rat enteric neurones by the receptor for advanced glycation end-products. J Neurogastroent Motil, 18(5) 392-400. Portier B, Ferrari D, Taglialatela G (2006): Rapid assay for quantitative measurement of apoptosis in cultured cells and brain tissue. J Neurosci Meth, in press.
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