Kyungsoon Chung, Ph.D.
Department of Neuroscience & Cell Biology
- Route: 1069 2.102 Medical Research Building (MRB)
- Tel: (409) 747-4174
- Fax: (409) 762-9382
- Chung CV
Kyungsoon Chung, Ph.D.
Bachelor of Science, Sogang University, 1969
Doctor of Philosophy, Loyola University, Stritch School of Medicine, 1978
Post-Doctoral Training, University of Texas Medical Branch, 1978-1979
About the Lab
Pain is one of the most common reasons patients seek help from medical professionals. In contrast to acute pain which has a protective function, chronic pain is a state with maintained abnormalities in both the central nervous system and periphery. Dr. Chung is interested in the mechanisms of chronic pain. The studies in her laboratory include the changes in behavior, morphology, and physiological properties in primary afferent neurons and spinal dorsal horn neurons following peripheral nerve injury or tissue inflammation. The current studies focus on mitochondrial production of highly reactive oxygen species (free radicals) and their role in sensitization of spinal dorsal horn neurons and pain.
Park, E-S, Gao, X., Chung, J.M., and Chung, K. Levels of mitochondrial reactive oxygen species increase in rat neuropathic spinal dorsal horn neurons. Neurosci. Lett., 391:108-111, 2006.
Gao, X., Kim, H.K., Chung, J.M. and Chung, K. Reactive oxygen species (ROS) are involved in enhancement of NMDA-receptor phosphorylation in animal models of pain. Pain, 131:262-271, 2007.
Lee, I., Kin, H.K., Kim, J.H., Chung, K. and Chung, J.M. The role of reactive oxygen species in capsaicin-induced mechanical hyperalgesia and in the activities of dorsal horn neurons. Pain,133: 9-17, 2007.
Schwartz, E.S., Lee, I., Chung, K., and Chung, J.M. Oxidative stress in the spinal cord is an important contributor in capsaicin-induced mechanical secondary hyperalgesia in mice. Pain, 138:514-524, 2008. PMID: 18375065; PMC2581506
Kim, H.Y., Chung, J.M. and Chung, K. Increased production of mitochondrial superoxide in the spinal cord induces pain in mice: the effect of mitochondrial electron transport complex inhibitors. Neurosci. Lett., 447:87-91, 2008. PMCID: 2722070; NIHMS90374
Schwartz, E.S., Kim, H.Y., Wang, J., Lee, I.H., Klann, E., Chung, J.M. and Chung, K. Persistent pain is dependent on spinal mitochondrial antioxidant levels. J. Nerousci., 29(1):159-168, 2009. PMCID: 2757011, NIHMS85922
Kim, H.Y., Wang, J., Lu, W., Chung, J.M., and Chung, K. Superoxide signaling in pain is independent of nitric oxide signaling. NeuroReport. 20(16):1424-1428, 2009. PMID19794317