Rinat O. Esenaliev, Ph.D.

Professor

  • Affiliations:
    Department of Neuroscience & Cell Biology,
    and Department of Anesthesiology,
    Director of Laboratory for Optical Sensing and Monitoring,
    Director of High-resolution Ultrasound Imaging Core,
    Scientist, Center for Biomedical Engineering,
    UTMB Cancer Center
    University of Texas Medical Branch
  • Route: 1156, 4.410C Research Building 21
  • Tel: (409) 772-8144
  • Fax: (409) 772-8144
  • riesenal@utmb.edu
  • Esenaliev CV

Rinat O. Esenaliev, Ph.D.

Research Focus

Dr. Esenaliev's research is in the field of bioengineering and biophysics.  The main focus of his research is in novel applications of biophotonic technology for non-invasive and continuous monitoring of multiple important physiological parameters and for non-invasive, efficient cancer therapy.  Dr. Esenaliev is developing high-resolution optical techniques (such as optoacoustic technique, optical coherence tomography) for non-invasive, continuous, and absolute measurement of cerebral and central venous blood oxygenation, total hemoglobin concentration, and blood glucose concentration.  His research interests include novel cancer therapy based on interaction of nanoparticles with electromagnetic or ultrasound radiation. Successful development of these techniques will substantially improve treatment of acute life-threatening illnesses, diabetes, and cancer. 

Major Inventions and Research Interests:

1. Novel diagnostic imaging modality: Optoacoustic/Photoacoustic Imaging and Tomography.

2. Nanoparticle-based therapy of tumors and drig delivery in tumors using laser, radiofrequency, microwave, or ultrasound radiation.

3. Real-time, noninvasive optoacoustic/photoacoustic monitoring of tissue properties.

4. Noninvasive, continuous monitoring of blood oxygenation including oxygenation in cerebral and central veins.

5. Noninvasive measurement and monitoring of total hemoglobin concentration.

6. Noninvasive monitoring of blood glucose concentration with Optical Coherence Tomography.

Selected Awards

UT System Chancellor’s Innovation and Entrepreneurship Award for "Multiple Therapeutic and Diagnostic Methods and Devices", 2010.

Education

1984  B.S.    Theoretical and Experimental Physics, Moscow Institute of Physics and Technology*

1987  M.S.    Applied Biophysics, Moscow Institute of Physics and Technology*

1992  Ph.D.    Applied Biophysics, Institute of Spectroscopy, Russian Academy of Sciences**

*Ranked #1 in Higher Education on Physics and Technology in Russia.

**One of the 10 Top Institutes of Russian Academy of Sciences. 

Active Projects:

1. Moody Center for Traumatic Brain & Spinal Cord Injury Research/Mission Connect. Program Grant.

2. Texas Emerging Technology Fund (TETF). "Noninvasive Platform for Blood Diagnostics", Subaward from Noninvasix, Inc.

3. Pinnacle Innovation, LLC. "Pilot Study of Insertable, Optical Reflectance-based Glucose Sensor". Contract.

4. DOD. "Non-Invasive Monitoring of Cerebral Venous Saturation in Patients with Traumatic Brain Injury". Contract.

5. NIH STTR grant "Rapid, Noninvasive Diagnosis and Monitoring of Shock". Subaward from Noninvasix, Inc.

6. DOD. "Rapid and Safe Assessment of Circulatory Shock with a Novel Noninvasive Technique". Contract.

Completed Projects:

1. The Whitaker Foundation, Biomedical Engineering Research Grants Program, "Laser Optoacoustic Imaging for Breast Cancer Detection".

2. Bayer Corporation, Research Agreement, "Dye-assisted Laser Poration of Skin for Minimally-Invasive Monitoring of Biomolecules in Dermal ISF".

3. National Medical Technology Testbed, Cooperative Agreement, "Novel Optoacoustic Monitoring System for Non-Invasive Measurement of Blood Oxygenation in Brain".

4. John Sealy Memorial Endowment Fund for Biomedical Research, Recruitment Grant Program, "Radiation-Enhanced Drug Delivery in Tumors".

5. Advanced Technology Program of the Texas Higher Education Coordinating Board, ATP-99, Research Grant, "Non-invasive Glucose Sensing with a Novel Optical Technique".

6. NIH (NIDDK) R21, Research Grant, "OCT-based Glucose Sensor".

7. NIH (NINDS) R21, Research Grant, "Optoacoustic Monitoring of Cerebral Blood Oxygenation".

8. Advanced Technology Program of the Texas Higher Education Coordinating Board, ATP-01, Research Grant, "Development of Novel System for Drug Delivery in Tumors".

9. DOD, Breast Cancer Research Program, Idea Award, "Novel Drug Delivery Technique for Breast Cancer Therapy".

10. National Medical Technology Testbed, Cooperative Agreement, "Novel Optoacoustic Monitoring System for Non-Invasive Measurement of Blood Oxygenation in Brain".

11. NIH (NIBIB) R01, Research Grant, "Novel Sensor for Measurement of Blood Oxygenation".

12. NIH (NINDS) R01, Research Grant, "Optoacoustic Monitoring of Cerebral Blood Oxygenation".

13. DOD, Prostate Cancer Research Program, Idea Award, "Prostate Cancer Therapy with Novel Drug Delivery Technique".

14. NIH (NIBIB) R01, Research Grant, "Continuous Glucose Monitoring in Critically Ill Patients".

15. John Sealy Memorial Endowment Fund, Bridging Grant Program, "Noninvasive Monitoring with Novel, High-resolution Optical Techniques".

16. NIH (NCI) R01, Research Grant, "Surgical Studies of Signaling Pathways in GI Cancers".

17. UTMB Seed Grant, "Initial Tests of Noninvasive, Optoacoustic Hemoglobin Monitoring Prototype".

Total costs of the research grants received as PI only: $5,963,024 and as PI or Co-PI only: $9,564,918.

Publications (selected from a total of 150 papers, patents, and book chapters, excluding abstracts) 

Issued Patents:

1. "Optoacoustic Imaging for Medical Diagnosis" (US #5,840,023 and corresponding international patents, 11/24/98). Oraevsky A.A., Jacques S.L., Esenaliev R.O.

2. Radiation and Nanoparticles for Enhancement of Drug Delivery in Solid Tumors" (US #6,165,440, 12/26/00). Esenaliev R.O.

3. "Real Time Optoacoustic Monitoring of Changes in Tissue Properties" (US #6,309,352, 10/30/01). Esenaliev R.O., Motamedi M., Karabutov A.A., Oraevsky A.A.

4. "Optoacoustic Monitoring of Blood Oxygenation." R.O. Esenaliev, M. Motamedi, D.S. Prough, A.A. Oraevsky. (US #6,498,942, 12/24/02).

5. "Methods for Noninvasive Analyte Sensing." M. Motamedi, R.O. Esenaliev. (US #6,725,073, 04/20/04).

6. "Continuous Optoacoustic Monitoring of Hemoglobin Concentration and Hematocrit." R.O. Esenaliev, M. Motamedi, D.S. Prough. (US #6,751,490 and corresponding international patents, 06/15/04).

7. "Noninvasive Blood Analysis by Optical Probing of the Veins under the Tongue." R.O. Esenaliev, D.S. Prough. (US #7,430,445, 09/30/08).

8. "Implantable Biosensor with Stratified Nanostructured Membranes". M. Motamedi, N.A. Kotov, J.P. Wicksted, R.O. Esenaliev. (US #7,863,038, 01/04/11).

9. "Noninvasive Glucose Sensing Methods and Systems." R.O. Esenaliev, D.S. Prough. (US #8,135,450 B2, 03/13/12).

Peer-reviewed papers:

1. Esenaliev R.O., Larina I.V., Larin K.V., Deyo D.E., Motamedi M., Prough D.S.  Optoacoustic Technique for Noninvasive Monitoring of Blood Oxygenation: A Feasibility Study. Applied Optics (Optical Technology and Biomedical Optics). v. 41(22), pp. 4722-4731, 2002.

2. Larin K.V., Eledrisi M.S., Motamedi M., Esenaliev R.O. Noninvasive Blood Glucose Monitoring with OCT Technique: A Pilot Clinical Study in Human Subjects. Diabetes Care, v.25(12), pp. 2263-2267, 2002.

3. Larin K.V., Larina I.V., Motamedi M., Esenaliev R.O. Optoacoustic Laser Monitoring of Cooling and Freezing of Tissues. Quantum Electronics, v.32(11), pp. 953-958, 2002.

4. Larin KV, Motamedi M, Ashitkov TV, Esenaliev RO Specificity of Noninvasive Blood Glucose Sensing Using Optical Coherence Tomography Technique: A Pilot Study, Physics in Medicine and Biology, v.48 pp. 1371-1390, 2003.

5. Kholodnykh A.I., Petrova I.Y., Larin K.V., Motamedi M., Esenaliev R.O. Precision of Measurement of Tissue Optical Properties with OCT. Applied Optics (Special Issue on Biomedical Optics), v. 42(16), pp.3027-3037, 2003.

6. Kholodnykh A.I., Petrova I.Y., Motamedi M., Esenaliev R.O. Accurate Measurement of Total Attenuation Coefficient of Thin Tissue with Optical Coherence Tomography. Journal of Selected Topics on Quantum Electronics (Special Issue on Lasers in Medicine and Biology), v. 9(2), pp.210-221, 2003.

7. Hosseini K., Kholodnykh A.I., Petrova I.Y., Esenaliev R.O., Hendrikse F., Motamedi M. Monitoring of Rabbit Cornea Response to Dehydration Stress by Optical Coherence Tomography. Investigative Ophthalmology Vis. Sci., v.45, pp.2555-2562, 2004.

8. Larin K.V., Akkin T., Esenaliev R.O., Motamedi M., Milner T.E. Phase-Sensitive Optical Low-coherence Reflectometry for the Detection of Analyte Concentration. Applied Optics, v.43(17), pp.3408-3414, 2004.

9. Esenaliev R.O., Petrov Y.Y., Hartrumpf O., Deyo D.E., Prough D.S. Continuous, Noninvasive Monitoring of Total Hemoglobin Concentration by an Optoacoustic Technique. Applied Optics (Optical Technology and Biomedical Optics), v. 43(17), pp. 3401-3407, 2004.

10.Petrov Y.Y., Prough D.S., Deyo D.E., Klasing M., Motamedi M., Esenaliev R.O. Optoacoustic, Noninvasive, Real-time, Continuous Monitoring of Cerebral Blood Oxygenation: An In vivo Study in Sheep. Anesthesiology, v. 102(1), pp. 69-75, 2005 (The article is featured in "This Month in Anesthesiology").

11. Larina I.V., Larin K.V., Esenaliev R.O. Real-time Optoacoustic Monitoring of Temperature in Tissues. Journal of Physics D: Applied Physics, v. 38(15), pp.2633-2639, 2005.

12. Larin K.V., Larina I.V., Esenaliev R.O. Monitoring of Tissue Coagulation during Thermotherapy using Optoacoustic Technique. Journal of Physics D: Applied Physics, v. 38(15), pp.2645-2653, 2005.

13. Larina I.V., Evers B.M., Esenaliev R.O. Optimal Drug and Gene Delivery in Cancer Cells by Ultrasound-Induced Cavitation. Anticancer Research, v. 25(1), pp. 149-156, 2005.

14. Larina I.V., Evers B.M., Ashitkov T.V., Bartels C., Larin K.V., Esenaliev R.O. Enhancement of Drug Delivery in Tumors by Using Interaction of Nanoparticles with Ultrasound Radiation. Technology in Cancer Research and Treatment, v. 4(2), pp. 217-226, 2005 (This article is featured in the NCI Alliance for Nanotechnology in Cancer website).

15. Petrova I.Y., Esenaliev R.O., Petrov Y.Y., Brecht H.-P.F., Svensen C.H., Olsson J., Deyo D.J., Prough D.S., "Optoacoustic Monitoring of Blood Hemoglobin Concentration: A pilot clinical study". Optics Letters, vol. 30, no. 13, pp. 1677-1679, 2005

16. Chumakova O.V., Liopo A.V., Evers B.M., Esenaliev R.O. Effect of 5-fluorouracil, Optison and ultrasound on MCF-7 cell viability. Ultrasound in Medicine and Biology, v. 32(5), 2006, pp. 751-758.

17. Petrov Y.Y., Petrova I.Y., Patrikeev I.A., Esenaliev R.O., Prough D.S. Multiwavelength optoacoustic system for noninvasive monitoring of cerebral venous oxygenation: a pilot clinical test in the internal jugular vein. Optics Letters, v. 31(12) pp. 1827-1829, 2006.

18. Kuranov R.V., Sapozhnikova V.V., Prough D.S., Cicenaite I., Esenaliev R.O. In vivo study of glucose-induced changes in skin properties assessed with optical coherence tomography.  Physics in Medicine and Biology, 2006, v. 51(16), pp.3885-3900.

19. Sapozhnikova V.V., Prough D., Kuranov R.V., Cicenaite I., Esenaliev R.O. Influence of osmolytes on in vivo glucose monitoring using optical coherence tomography. Experimental Biology and Medicine, 2006, v. 231(8), pp. 1323-1332.

20. Kuranov R.V., Sapozhnikova V.V., Prough D.S., Cicenaite I., Esenaliev R.O. In vivo study of glucose-induced changes in skin properties assessed with optical coherence tomography.  Phys Med Biol, 2006, v. 51(16), pp.3885-3900.

21. Petrov Y.Y., Petrova I.Y., Patrikeev I.A., Esenaliev R.O., Prough D.S. Multiwavelength optoacoustic system for noninvasive monitoring of cerebral venous oxygenation: a pilot clinical test in the internal jugular vein. Optics Letters, v. 31(12) pp. 1827-1829, 2006.

22. Kuranov R.V., Sapozhnikova V.V., Prough D.S., Cicenaite I., Esenaliev R.O. Correlation between OCT images and histology of pig skin.  Applied Optics, v.46(10), pp. 1782-1786, 2007.

23. Kuranov R.V., Sapozhnikova V.V., Prough D.S., Cicenaite I., Esenaliev R.O. Prediction capability of  Optical Coherence Tomography for blood glucose concentration monitoring.  Journal of Diabetes Science and Technology, v.1(4), pp. 164-171, 2007.

24. Patrikeev I., Y. Y. Petrov, I. Y. Petrova, D. S. Prough, R. O. Esenaliev. Monte Carlo Modeling of Optoacoustic Signals from Human Internal Jugular Veins. Applied Optics, Applied Optics, v.46(21), pp.4820-4827, 2007.

25. Brecht H. P., D. Prough, I. Patrikeev, D. Deyo, Y. Petrov, I. Cicenaite and R. Esenaliev. In vivo monitoring of blood oxygenation in large veins with a triple-wavelength optoacoustic system. Optics Express, v.15(24), pp. 16261-16269, 2007.

26. Sapozhnikova V.V., Kuranov R.V., Cicenaite I., Esenaliev R.O., Prough D.S. Effect on glucose monitoring of skin pressure exerted by an optical coherence tomography probe. Journal of Biomedical Optics, 2008, v. 13(2), 021112.

27. Chumakova O.V., Liopo A.V., Andreev V.G., Cicenaite I., Evers B.M., Chakrabarty S., Pappas T.C., Esenaliev R.O. Composition of PLGA and PEI/DNA nanoparticles improves ultrasound-mediated gene delivery in solid tumors in vivo. Cancer Letters, 2008, 261(2), pp. 215-225.

28. Esenaliev R.O., Prough D.S. Noninvasive Monitoring of Glucose Concentration with Optical Coherence Tomography. In: "Handbook of Optical Sensing of Glucose in Biological Fluids and Tissues", ed. by Valery Tuchin, Taylor and Francis, 2009.

29. Petrova I. Y., Y. Y. Petrov, R.O. Esenaliev, D. E. Deyo, I. Cicenaite and D.S. Prough. Noninvasive monitoring of cerebral blood oxygenation in ovine superior sagittal sinus with novel multi-wavelength optoacoustic system. Optics Express, v.17(9), pp. 7285-7294, 2009.

30. Esenaliev R.O. Biomedical Optoacoustics. Journal of Innovative Optical Health Sciences, Special Issue in Honor of Steven L. Jacques for His 60th Birthday, v.4(1) pp. 39-44, 2011.

31. Petrov I.Y., Y. Petrov, D.S. Prough, D.J. Deyo, I. Cicenaite and R.O. Esenaliev. Optoacoustic monitoring of cerebral venous blood oxygenation through extracerebral blood. Biomedical Optics Express, published on-line in 2011; v.3(1), pp. 125-136, 2012.

32. Petrov I.Y., Y. Petrov, D.S. Prough, I. Cicenaite, D.J. Deyo and R.O. Esenaliev. Optoacoustic monitoring of cerebral venous blood oxygenation through intact scalp in large animals. Optics Express, v.20(4), pp. 4159-4167, 2012.

33. Figueiredo M. and R.O. Esenaliev. PLGA nanoparticles for ultrasound-mediated gene delivery to solid tumors. Journal of Drug Delivery. Special Issue "Nanoparticles for targeted delivery of active agents against tumor cells", v. 2012, 767839, pp. 1-20, 2012.