Danxia Liu, Ph.D.

Professor, Departments of Neurology and Biochemistry & Molecular Biology; Associate Member of the Graduate Faculty and the Neuroscience Graduate Program

Division/ Program Title:

Department of Neurology

Mailing Address:

301 University Blvd, Route 0881
Galveston, TX 77555-0881

Office:

2.152 Brackenridge Hall

Phone:

(409) 747-4558

Fax:

(409) 747-3065

Education and Post Graduate Training:

 

  • Undergraduate, Beijing (Peking) University, Beijing, China (1959-1963)
  • Graduate, Beijing University (1963-1965)
  • Post-graduate, Chinese Academy of Medical Science, Beijing, China (1965-1966)
  • Graduate, Beijing University, Beijing, China (1979-1982)
  • Post-graduate, the University of Tennessee at Memphis,
  • College of Medicine, Memphis, Tennessee (1986-1987)
  • Post-graduate, the Ohio State University, Columbus, Ohio (1987-1988)
  • Link to CV

Board Certifications:

  • N/A

Specialties:

Physics, Biophysics, Biochemistry, Neurochemistry, Neuroscience

Clinical Interest:

  • N/A

Research Interest:

  • To identify substances that contribute to secondary damage after central nervous system (CNS) injury
  • To explore the molecular mechanisms of neuronal degeneration and death caused by these substances following CNS injury
  • To develop therapeutic strategies to prevent secondary CNS injury
  • To investigate the roles and pathways by which reactive species cause secondary CNS injury and to explore the therapeutic potential of antioxidant therapy in spinal cord injury.
  • To identify the proteins most susceptible to oxidative damage following CNS injury by utilizing proteomic technology. 

Selected Publications:

Selected from 50 research articles published in peer-reviewed journals
Liu, D., Shan, Y., Valluru, L., and Bao, F. Mn (III) tetrakis (4-benzoic acid) porphyrin scavenges reactive species, reduces oxidative stress, and improves functional recovery after experimental spinal cord injury in rats: Comparison with methylprednisolone. BMC Neuroscience, 14:23. 2013, DOI: 10.1186/1471-2202-14-23. URL: http://www.biomedcentral.com/1471-2202/14/23

Valluru, L., Diao, Y., Hachmeister, J. E., and Liu, D. Mn (III) tetrakis (4-benzoic acid) porphyrin protects against neuronal and glial oxidative stress and death after spinal cord injury. CNS Neurol. Disord. Drug Targets. 11: 774-790, 2012.

Liu, D., Bao, F., Wen, J., and Liu, J. Mutation of superoxide dismutase elevates reactive species: Comparison of nitration and oxidation of proteins in different brain regions of transgenic mice with amyotrophic lateral sclerosis. Neuroscience, 146: 255-264, 2007

Hachmeister, J. E., Valluru, L., Bao, F., and Liu, D. Mn (III) tetrakis (4-benzoic acid) porphyrin administered into the intrathecal space reduces oxidative damage and neuron death after spinal cord injury: A comparison with methylprednisolone. J. Neurotrauma, 23: 1766-1778, 2006.

Liu, D., Bao, F., Prough, D. S., and Dewitt, D. S. Peroxynitrite generated at the level produced by spinal cord injury induces peroxidation of membrane phospholipids in normal rat cord: Reduction by a metalloporphyrin. J. Neurotrauma 22: 1123-1133, 2005

Liu, D., Liu, J., Sun, D., and Wen, J. The time course of hydroxyl radical formation following spinal cord injury: The possible role of the iron-catalyzed Haber-Weiss reaction. J. Neurotrauma, 21, 805-816, 2004.

Bao, F., and Liu, D. Peroxynitrite generated in the rat spinal cord induces apoptotic cell death and activates caspase-3. Neuroscience, 116:59-70, 2003.

Liu, D., Li, L., and Augustus, L. Prostaglandin release by impact injury mediates hydroxyl radical and malondialdehyde production and cell death: A site of the neuroprotective action of methylprednisolone. J. Neurochem. 77: 1036-1047, 2001.

Liu, D., Ling, X., Wen, J., and Liu, J. The role of reactive nitrogen species in secondary spinal cord injury: Formation of nitric oxide, peroxynitrite, and nitrated protein. J. Neurochem. 75: 2144-2154, 2000.

Liu, D., Wen, J., Liu, J., and Li, L. The roles of free radicals in amyotrophic lateral sclerosis: Reactive oxygen species and elevated oxidation of protein, DNA and membrane phospholipids. FASEB Journal, 13: 2318-2328, 1999.

Honors and Awards:

Annual Outstanding Researcher for each year from 1972 to 1976 in Biology Research Institute.

Second Prize for Scientific and Technical Achievement of Beijing City (1978-1979).

Prize for Outstanding Investigator at Beijing University (1983-1984).

Professional Affiliations:

Member, National Institute of Health, Special Emphasis Panel for RFA (ZNS1 SRB-R 01), 2000

Ad-hoc reviewer, Paralyzed Veterans of America, Spinal Cord Research Foundation

Ad-hoc reviewer, Department of Veterans Affairs, Western Research & Development Center

Journal Reviewer For Annuals of Neurology, the Journal of Neuroscience, Journal of Neurochemistry, Neuroscience, Experimental Neurology, Brain Research, Neuroscience Letters, Free Radical Biology and Medicine, Neurochemistry International, Anesthesiology, Anesthesia & Analgesia