Giulio Taglialatela, Ph.D.

Professor and Vice Chair for Research
Director, Mitchell Center for Neurodegenerative Diseases

Division/ Program Title:

Professor and Vice Chair for Research
Director, Mitchell Center for Neurodegenerative Diseases

Mailing Address:

301 University Blvd, Route 1045
Galveston, TX 77555-1045

Office:

10.138 Medical Research Building

Phone:

(409) 772-1679

Fax:

(409) 747-0015

Education and Post Graduate Training:

 

  • 1984: M.S. Biology (Neuroendocrinology), University of Rome “La Sapienza”, Rome, Italy
  • 1988: Ph.D Neuropharmacology, University of Rome “La Sapienza”, Rome, Italy
  • 1990: Postdoc, Dept. of Human Biological Chemistry & Genetics (currently Biochemistry & Molecular Biology), UTMB Galveston, Texas
  • Link to CV

Board Certifications:

  • N/A

Specialties:

  • N/A

Clinical Interest:

  • N/A

Research Interest:

  • Molecular mechanisms of neurodegeneration and cognitive decline in Alzheimer Disease and related disorders

Selected Publications:

  • (from 85 peer-reviewed publications)Karlnoski R, Wilcock D, Dickey C, Ronan V, Gordon MN, Zhang WR, Morgan D, Taglialatela G (2007): Up-Regulation of Bcl-2 in APP Transgenic Mice is Functionally Neuroprotective, Neurobiol Dis, 25(1):179-88; E-pub ahead of print October 25, 2006.
  • Dineley K, Hogan D, Zhang W, Taglialatela G (2007): Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice. Neurobiol Learn Mem. 88(2):217-224.
  • Reese LC, Zhang W, Dineley KT, Kayed R, Taglialatela G (2008): Selective induction of calcineurin activity and signaling by amyloid beta oligomers. Aging Cell, 7:824-835.
  • Taglialatela G, Hogan D, Zhang W, Dineley K (2009): Intermediate and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition. Behav Brain Res, 200(1):95-9.
  • Vascotto C, Cesaratto L, Zeef LA, Deganuto M, D’Ambrosio C, Scaloni A, Romanello M, Damante G, Taglialatela G, Delneri D, Kelley MR, Mitra S, Quadrifoglio F, Tell G (2009): Genome-wide analysis of proteomic studies reveal APE/Ref-1 multifunctional role in mammalian cells. Proteomics 9(4):1058-74.
  • Dineley K, Kayed R, Neugebauer V, Yu F, Zhang W, Reese L, Taglialatela G (2010): Calcineurin mediates memory deficits induced by Intracerebral injection of amyloid beta oligomers in mice. J Neurosci Res, 88(13):2923-32.
  • McNearney TA, Ma Y, Chen Y, Taglialatela G, Yin H, Zhang WR, Westlund KN (2010): A peripheral neuroimmune link: glutamate agonists upregulate NMDA NR1 receptor mRNA and protein, vimentin, TNF-alpha, and RANTES in cultured human synoviocytes. Am J Physiol Regul Integr Comp Physiol. 298(3):R584-98.
  • Mukherjee A, Morales R, Gonzales D, Green K, Taglialatela G, Soto C (2010): Calcineurin Inhibition at the Clinical Phase of Prion Disease Decreases Neurodegeneration Leading to Clinical Improvement and Increase of Animal Survival. PLoS Pathogens, 6(10):1-12.
  • Reese L and Taglialatela G (2010): Neuroimmunomodulation by calcineurin in aging and Alzheimer Disease. (Invited review) Aging and Disease, 2010.
  • Dineley KT, Kayed R, Neugebauer V, Fu Y, Zhang W, Reese LC, Taglialatela G (2010): Amyloid-beta oligomers impair fear conditioned memory in a calcineurin-dependent fashion in mice. J Neurosci Res. Oct;88(13):2923-32.
  • Reese LC, Laezza F, Woltjer R, Taglialatela G (2011): Dysregulated phosphorylation of Ca++/Calmudulin-dependent protein kinase IIa in the hippocampus of subjects with mild cognitive impairment and Alzheimer’s disease. J Neurochem, 119(4)791-804
  • Reese L and Taglialatela G (2011):  A role for calcineurin in Alzheimer’s Disease. (Invited review) Curr Neuropharm, 9(4):685-92.
  • Crawford J, Taglialatela G, Bjorklund N, Gomer R (2012): Brain Serum amyloid P levels are reduced in individuals that lack dementia while having Alzheimer's disease neuropathology. Neurochem Res, 37(4):795-801.
  • Bjorklund NL, Sadagoparamanujam VM, Taglialatela G (2012): Selective, quantitative measurement of releasable synaptic zinc in human autopsy hippocampal brain tissue from Alzheimer’s disease patients. Neurosci Methods, 2012, 203(1):146-151
  • Mantha A., Dhiman M., Tagliatatela G, Perez-Polo R, Mitra S (2012): Proteomic Study of Amyloid Beta (25-35) Peptide Exposure to Neuronal Cells: Impact on APE1/Ref-1’s Protein-Protein Interaction. J Neurosci Res, 90(6):1230-9
  • Martin ZS, Neugebauer V, Dineley KT, Kayed R, Zhang W, Reese LC, Taglialatela G (2012): Alpha synuclein oligomers oppose long term potentiation and impair memory through a calcineurin-dependent mechanism: relevance to human synucleopathic diseases. J Neurochem, 120(3):440-52.
  • Bjorklund NL, Reese LC, Sadagoparamanujam VM, Ghirardi V, Woltjer RL, Taglialatela G (2012): Absence of amyloid beta oligomers at postsynapse and regulated synaptic zinc in cognitively intact aged individuals with Alzheimer’s disease neuropathology. Mol Neurodegener  7(1):23.
  • Stoica G, Lungu G, Bjorklund NL, Taglialatela G, Zhang X, Chiu V, Hill HH, Schenk JO, Murray I. (2012): Potential role of alpha synuclein in Neurodegeneration: Studies in a rat animal model. J Neurochem, 122(4):812-22.
  • Sallam HS, Tuvdendorj D, Tumurbaatar B, Zhang W, Taglialatela G, Nicola Abate (2014): Peripheral adipose tissue insulin resistance alters lipid composition of CNS hippocampal synapses. J Neurosci Res, submitted.
  • Bjorklund NL, Ghirardi V, Zhang W, Taglialatela G (2014). Sustained hippocampal neurogenesis in non demented individuals with Alzheimer neuropathology. In preparation.
  • Bjorklund NL, Sadagoparamanujam VM, Cicalese P, Taglialatela G (2014). Differential metal regulation and preserved metallothionin-3 levels in the CNS of non demented individuals with Alzheimer neuropathology. In preparation.

Honors and Awards:

  • Elected President, Society for Neuroscience Galveston Chapter.
  • Elected Chair, UTMB Faculty Senate (2002)
  • Graduate Program Teaching Excellence Award in Neuroscience (2010)
  • Appointed Mace Bearer, UTMB GSBS Commencement (2012)
  • Appointed Chair, Biophysical, Physiological, Pharmacological and Bioengineering Neuroscience Study Section, NIH.
  • Graduate School Faculty Service Award (2013)
  • Graduate School/GSO Teaching Excellence Award (2013)
  • Graduate Program Teaching Excellence Award in Neuroscience (2014)

Professional Affiliations:

  • Society for Neuroscience
  • American Society for Neurochemistry