R. Glenn Smith, M.D., Ph.D.

Professor and Vice Chair for Faculty Affairs

Division/ Program Title:

Department of Neurology

Mailing Address:

301 University Blvd, Route 0539
Galveston, TX 77555-0539


9.128 John Sealy Annex


(409) 772-8053


(409) 772-6940

Education and Post Graduate Training:


  • Medical School: Baylor College of Medicine, Houston, TX (1977-1979,1984-1986)
  • PhD in Biochemistry: Baylor College of Medicine, Houston, TX (1979-1984)
  • Internal Medicine Internship - Baylor Affiliated Hospitals, Houston, TX (1986-1987)
  • Neurology Residency: Baylor College of Medicine, Houston, TX (1987-1990)
  • Resident Instructorship / Chief: Baylor College of Medicine, Houston, TX (1989-1990)
  • Fellowship in Neuromuscular Medicine and Neurodegenerative Diseases: Baylor College of Medicine, Houston, TX (1990-1991)
  • American Federation for Aging Research Fellowship (1997-1999)
  • Link to CV
Board Certifications:
  • Neurology (American Board of Psychiatry and Neurology)
  • Neuromuscular Medicine (ABPN)
  • Electrodiagnostic Medicine (AANEM)
  • Autonomic Disorders (UCNS)
  • Neuromuscular diseases, Neuroimmunology, Autonomic disorders

Research Interest:

  • Immune-mediated neurologic disease
      Atypical presentations of inflammatory neuropathies and their etiologies
      Immunology of myasthenia gravis
      Prediabetic neuropathy
      Mitochondrionopathies; biochemical and genetic associations
  • Neurodegenerative diseases
      Etiopathogenesis of Amyotrophic lateral sclerosis
      Previous Coinvestigator, site Principal Investigator, or Senior Investigator on 28 clinical Phase II-IV trials; Previous Co-Investigator or Co-PI on 6 NIH sponsored RO-1 grants

Selected Publications:

  • Selected recent publications from 80 peer reviewed research publications and review articles, and from over 60 abstracts
  • Oshima M, Deitiker P, Smith RG, Mosier D, Atassi MZ. T-cell recognition of acetylcholine receptor provides a reliable means for monitoring autoimmunity to acetylcholine receptor in antibody-negative myasthenia gravis patients. Autoimmunity 45(2):153-160. doi:10.3109/08916934.2011.611550 (2012).
  • Deitiker PR, Oshima M, Smith RG, Mosier D, Atassi MZ. Association with HLA DQ of early onset myasthenia gravis in Southeast Texas region of the United States. Int J Immunogenet. 38(1):55-62. doi: 10.1111/j.1744 313X.2010.00979.x. Epub 2010 Nov 25. (2011)
  • Deitiker PR, Oshima M, Smith RG, Mosier DR, Atassi MZ. Subtle differences in HLA DQ haplotype-associated presentation of AChR alpha-chain peptides may suffice to mediate myasthenia gravis. Autoimmunity 39:277-88 (2006).
  • Oshima M, Ohtani M, Deitiker PR, Smith RG, Mosier DR, Atassi MZ. Suppression by mAbs against DQB1 peptides of in vitro proliferation of AChR-specific T cells from myasthenia gravis patients. Autoimmunity 38:161-169 (2005).
  • Vigh L, Smith RG, Soos J, Engelhardt JI, Appel SH, Siklos L. Sublethal dose of 4-hydroxynonenal reduces intracellular calcium in surviving motor neurons in vivo. Acta Neuropathol (Berl) 109:567-575 (2005).
  • Simpson EP, Henry YK, Henkel JS, Smith RG, Appel SH. Increased lipid peroxidation in sera of ALS patients: a potential biomarker of disease burden. Neurology 62:1758-65 (2004).
  • Smith RG, Roher A, Appel SH, Doody RS, Killian JM, Corey-Bloom J, Sabbagh M. Autonomic sudomotor dysfunction in Alzheimer’s disease. Curr Med Chem-Immun, Endoc & Metab 3:77-84 (2003).
  • Beers DR, Ho BK, Siklos L, Alexianu ME, Mosier DR, Mohamed AH, Otsuka Y, Kozovska ME, McAlhany RE., Smith RG, Appel S.H. Parvalbumin overexpression alters immune-mediated increases in [Ca2+], and delays disease onset in a transgenic model of fALS. J Neurochem 79:499-509 (2001).
  • Smith, R.G., Y.K. Henry, M.P. Mattson, and S.H. Appel. Presence of 4-hydroxynonenal in CSF of patients with sporadic ALS. Ann Neurol, 44:696-699 (1998).
  • Appel, S.H., R.G. Smith. The pathogenesis of Amyotrophic Lateral Sclerosis. In: Pathogenesis of Neurodegenerative Disorders (Mattson M.P., ed), Humana Press Inc., Totowa NJ, pp149-175 (2001).

For full list of publications:

Honors and Awards:

  • Paul Beeson Faculty Scholar (Hartford Foundation)
  • Fellow of the American Neurological Association.
  • Fellow of the American Association of Neuromuscular and Electrodiagnostic Medicine

Professional Affiliations:

  • American Academy of Neurology, 1994 F present
  • Texas Medical Association, 1990 - present
  • Texas Neurological Society, 1994 - present
  • Harris County Medical Society, 1990 - present
  • American Society for Neurochemistry, 1994 - present
  • American Society for Neurosciences, 1990 - 2000
  • AAAS, 1980 - present
  • American Association for Neuromuscular and Electrodiagnostic Medicine 2008 - present