Kelly T Dineley, Ph.D.

Associate Professor, Tenured

Division/ Program Title:

Mitchell Center for Neurodegenerative Disorders,
Department of Neurology
Center for Addiction Research
Director, Rodent In Vivo Assessment Core
Neuroscience Graduate Program
Pharmacology and Toxicology Graduate Program

Mailing Address:

301 University Blvd, Route 0616
Galveston, TX 77555-0616

Office:

Neuroscience Research Building (#17), Room 3.324D

Phone:

(409) 747-7060

Fax:

(409) 747-7050

Education and Post Graduate Training:

 

  • University of the Pacific - B.A., M.S.
  • Baylor College of Medicine - Ph.D.
  • Baylor College of Medicine - Postdoctoral Training
    (Laboratory of J David Sweatt, Ph.D.)

Research Interest:

  • Neurodegenerative diseases

  • Cognitive enhancement in early Alzheimer’s disease

  • Nuclear receptors in cognitive enhancement, maintenance of abstinence from psychostimulant abuse

  • Hippocampal memory consolidation - ERK MAPK

  • Nicotinic acetylcholine receptors - amyloid-β interaction

  • Cognitive dysfunction resulting from chronic pain

Selected Publications:

  • Dineley K.T., Westerman M., Bui D., Bell K., Hsiao Ashe K. and Sweatt J.D. Beta-amyloid activates the mitogen-activated protein kinase cascade through hippocampal α7 nicotinic acetylcholine receptors: in vitro and in vivo mechanisms related to Alzheimer’s disease. J. Neurosci. 21:4125-4133; 2001.

  • Dineley K.T., Xia X., Bui D., Sweatt J.D. and Zheng H. Accelerated plaque accumulation, associative learning deficits and up-regulation of α7 nicotinic acetylcholine receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. J. Biol. Chem. 277:22768-22780; 2002.

  • Dineley K.T., Bell K.A., Bui D., and Sweatt J.D. β-amyloid peptide activates α7 nicotinic acetylcholine receptors expressed in Xenopus oocytes. J. Biol. Chem. 277:25056-25061; 2002.

  • Bell K.A., O’Riordan K.J., Sweatt J.D., and Dineley K.T. MAPK recruitment by β-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time. J. Neurochem. 91:349-361; 2004.

  • Dineley, K.T., Hogan, D., Ru, W., Taglialatela, G. (2007) Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice. Neurobiol. Learn. Mem. 88(2):217-24, 2007 Sep.

  • Taglialatela, G., Hogan, D., Ru, W., Dineley, K.T. (2009) Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition. Behav. Brain. Res. 200(1):95-9.

  • Hernandez C.M., Kayed R., Zheng H, Sweatt J.D. and Dineley K.T. (2010) Loss of α7 nicotinic receptors enhances Aβ oligomer accumulation exacerbating early-stage cognitive decline and septo-hippocampal pathology in a mouse model for Alzheimer’s disease. J. Neurosci. 30(7):2442-2453.

  • Rodriguez-Rivera J., Denner, L.A., Dineley K.T. (2010) Rosiglitazone reversal of cognitive deficits in Tg2576 is independent of peripheral gluco-regulatory status. Behav. Brain Res. 216(1):255-61. PMID: 20709114

  • Parri HR, Hernandez CM, Dineley KT (2011) Research update: Alpha7 nicotinic acetylcholine receptor mechanisms in Alzheimer's disease. Biochem Pharmacol. 82(8):931-42. PMID: 21763291

  • Hernandez CM and Dineley KT (2012) α7 nicotinic acetylcholine receptors in Alzheimer’s disease: neuroprotective, neurotrophic or both? Curr Drug Targets. 13(5):613-22. PMID: 22300028

  • Denner LA, Rodriguez-Rivera J, Haidacher SJ, Jahrling JB, Carmical JR, Hernandez CM, Zhao Y, Sadygov RG, Starkey JM, Spratt H, Luxon BA, Wood TG, Dineley KT (2012) Cognitive Enhancement with Rosiglitazone Links the Hippocampal PPARĪ³ and ERK MAPK Signaling Pathways. J Neurosci 32(47):16725-35. PMID: 23175826

Honors and Awards:

08/15/12 Inclusion of “PPARgamma Drug Abuse Therapeutic” Project in Patient Impact Initiative (Partnership for Cures)

11/13/12 Diabetes: Funding, education and awareness
Galveston Daily News, Nov. 13, 2012
In this guest column by UTMB’s Larry Denner and Kelly Dineley: During aging, many people experience diminished control over blood glucose levels and the ability to produce or use insulin properly. This is called insulin resistance, which puts the elderly at risk for type 2 diabetes and may add to their risk for other age-related diseases.

05/31/13 Graduate student recipient of the UTMB Fisher Academic Excellence Award in Neuroscience - Cognitive Enhancement following PPARy Agonism is Mediated by a Hippocampal pERK-PPARy Complex

Professional Affiliations:

  • Alzheimer’s Association
  • Society for Neuroscience
  • American Association for the Advancement of Science
  • New York Academy of Sciences
  • Alzheimer’s Research Forum
  • Texas Alzheimer’s Disease Partnership