Kelly T Dineley, Ph.D.

Associate Professor, Tenured

Division/ Program Title:

Mitchell Center for Neurodegenerative Disorders,
Department of Neurology
Center for Addiction Research
Director, Rodent In Vivo Assessment Core
Neuroscience Graduate Program
Pharmacology and Toxicology Graduate Program

Mailing Address:

301 University Blvd, Route 0616
Galveston, TX 77555-0616

Office:

Neuroscience Research Building (#17), Room 3.324D

Phone:

(409) 747-7060

Fax:

(409) 747-7050

Education and Post Graduate Training:

 

  • University of the Pacific - B.A., M.S.
  • Baylor College of Medicine - Ph.D.
  • Baylor College of Medicine - Postdoctoral Training
    (Laboratory of J David Sweatt, Ph.D.)

Research Interest:

  • Alzheimer's disease, Parkinson's disease, and related amyloidopathies, tauopathies, synucleinopathies.
  • Animal models for cognitive decline in neurodegenerative disease utilizing genetic and pharmacological manipulations.
  • Cocaine abuse and cue-induced relapse following abstinence; protection with PPARγ nuclear receptor agonism.
  • Nuclear receptor (PPARγ), ERK MAPK, CREB, CBP, nicotinic acetylcholine receptors, protein-protein interactions.
  • Omics approaches to generate hypotheses that test key players and mechanisms for cognitive and operant disorders resulting from aging, neurodegenerative disease, and drug abuse.

Selected Publications:

  • Dineley KT, Pandya AA, Yakel JL. Nicotinic ACh receptors as therapeutic targets in CNS disorders. Trends Pharmacol Sci. 2015 Jan 29. pii:S0165-6147(14)00215-6. doi: 10.1016/j.tips.2014.12.002. Review. PubMed PMID: 25639674.
  • Dineley KT, Jahrling JB, Denner L. Insulin resistance in Alzheimer's disease. Neurobiol Dis. 2014 Dec;72 Pt A:92-103. doi: 10.1016/j.nbd.2014.09.001. Epub 2014 Sep 16. PubMed PMID: 25237037; PMCID: PMC4253975.
  • Nenov MN, Tempia F, Denner L, Dineley KT, Laezza F (2014) Impaired firing properties of dentate granule neurons in an Alzheimer's disease animal model are rescued by PPARγ agonism. J Neurophys Dec 24:jn.00419.2014. doi: 10.1152/jn.00419.2014.
  • Fawver JN, Ghiwot Y, Koola C, Carrera W, Rodriguez-Rivera J, Hernandez C, Dineley KT, Li J, Jhamandas J, Perry G, and Murray IVJ (2014) Islet Amyloid Polypeptide (IAPP) Association with Alzheimer's Disease Pathology and Diagnosis. Current Alzheimer's Res, Curr Alzheimer Res. 2014;11(10):928-40. PMID:25387341
  • Hernandez CM, Cortez I, Gu Z, Colón-Sáez JO, Lamb PW, Wakamiya M, Yakel JL, Dineley KT (2014) Research tool: validation of floxed α7 nicotinic acetylcholine receptor conditional knockout mice using in vitro and in vivo approaches. J Physiol. Aug 1;592(Pt 15):3201-14. doi: 10.1113/jphysiol.2014.272054. PMID: 24879866; PMCID: PMC4146370.
  • Jahrling JB, Hernandez CM, Denner L, Dineley KT (2014) PPARγ recruitment to active ERK during memory consolidation is required for Alzheimer's disease-related cognitive enhancement. J Neurosci. Mar 12;34(11):4054-63. doi: 10.1523/JNEUROSCI.4024-13.2014. PMID: 24623782
  • Nenov MN, Laezza F, Haidacher SJ, Zhao Y, Sadygov RG, Starkey JM, Spratt H, Luxon BA, Dineley KT, Denner L. (2013) Cognitive enhancing treatment with a PPARγ agonist normalizes dentate granule cell presynaptic function in Tg2576 APP mice. J Neurosci 34(3):1028-36. doi: 10.1523/JNEUROSCI.3413-13.2014
  • Pirttimaki T, Codadu NK, Awni A, Pratik P, Nagel D, Hill EJ, Dineley KT, Parri HR (2013) α7 nicotinic receptor-mediated astrocytic gliotransmitter release: Aβ effects in a preclinical Alzheimer's mouse model. PLoS ONE November 28;8(11):e81828. doi: 10.1371/journal.pone.0081828.
  • Denner LA, Rodriguez-Rivera J, Haidacher SJ, Jahrling JB, Carmical JR, Hernandez CM, Zhao Y, Sadygov RG, Starkey JM, Spratt H, Luxon BA, Wood TG, Dineley KT (2012) Cognitive Enhancement with Rosiglitazone Links the Hippocampal PPARγ and ERK MAPK Signaling Pathways. J Neurosci 32(47):16725-35. PMID: 23175826
  • Hernandez CM, Kayed R, Zheng H, Sweatt JD and Dineley KT (2010) Loss of α7 nicotinic receptors enhances Aβ oligomer accumulation exacerbating early-stage cognitive decline and septo-hippocampal pathology in a mouse model for Alzheimer's disease. J Neurosci. 30(7):2442-2453.
  • Taglialatella G, Hogan D, Zhang W-R and Dineley KT (2009) Intermediate- and long-term recognition memory deficits in Tg2576 mice are reversed with acute calcineurin inhibition. Behav Brain Res. 200(1):95-9.
  • Bell, K.A., O'Riordan, K.J., Sweatt, J.D. and Dineley, K.T. (2004) MAPK recruitment by -amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time. J. Neurochem. 91:349-361.
  • Dineley K.T., Bell K.A., Bui D., and Sweatt J.D. (2002) β-amyloid peptide activates α7 nicotinic acetylcholine receptors expressed in Xenopus oocytes. J. Biol. Chem. 277:25056-25061.
  • Dineley K.T., Xia X., Bui D., Sweatt J.D. and Zheng H. (2002) Accelerated plaque accumulation, associative learning deficits and up-regulation of α7 nicotinic acetylcholine receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. J. Biol. Chem. 277:22768-22780.
  • Dineley K.T., Westerman M., Bui D., Bell K., Hsiao Ashe K. and Sweatt J.D. (2001) Beta-amyloid activates the mitogen-activated protein kinase cascade through hippocampal α7 nicotinic acetylcholine receptors: in vitro and in vivo mechanisms related to Alzheimer's disease. J. Neurosci. 21:4125-4133.
  • Dineley K.T. and Patrick J. (2000) Molecular determinants of alpha7 nAChR surface expression. J. Biol. Chem. 275:13974-13985.

Honors and Awards:

08/15/12 Inclusion of “PPARgamma Drug Abuse Therapeutic” Project in Patient Impact Initiative (Partnership for Cures)

2012 Invited Member, Center for Houston's Future: The Regions Think Tank

11/13/12 Diabetes: Funding, education and awareness
Galveston Daily News, Nov. 13, 2012
In this guest column by UTMB’s Larry Denner and Kelly Dineley: During aging, many people experience diminished control over blood glucose levels and the ability to produce or use insulin properly. This is called insulin resistance, which puts the elderly at risk for type 2 diabetes and may add to their risk for other age-related diseases.

05/31/13 Graduate student recipient of the UTMB Fisher Academic Excellence Award in Neuroscience - Cognitive Enhancement following PPARy Agonism is Mediated by a Hippocampal pERK-PPARy Complex

Professional Affiliations:

  • Alzheimer’s Association
  • Society for Neuroscience
  • American Association for the Advancement of Science
  • New York Academy of Sciences
  • Alzheimer’s Research Forum
  • Texas Alzheimer’s Disease Partnership