Partha S. Sarkar, Ph.D.

Assistant Professor

Division/ Program Title:

Mitchell Center for Neurodegenerative Disorders, 
Department of Neurology

Mailing Address:

301 University Blvd, Route 0620
Galveston, TX 77555-0620

Office:

Research Building 17, Suite 4.212E

Phone:

(409) 747-4559

Fax:

(409) 747-6940

Education and Post Graduate Training:

Undergraduate (Honors in Chemistry); Calcutta University, India
Master of Science; Indian Institute of Technology, Bombay, India
Ph.D.; Molecular Biophysics, Indian Institute of Science, Bangalore, India

Link to CV

Board Certifications:

  • N/A

Specialties:

  • N/A

Clinical Interest:

  • N/A

Research Interest:

  • Mechanism of degenerative muscle phenotypes in myotonic dystrophy type 1 (DM1)
  • Mechanism of metabolic abnormalities in myotonic dystrophy type 1 (DM1)
  • Huntington disease (HD)
  • Spinocerebellar Ataxia Type 10 (SCA10)

Selected Publications:

Mandal, SM, Hegde ML, Chatterjee A, Hedge PM, Szczesny B, Bannerjee D, Bolgogh I, Gao R, Falkenberg M, Gustafsson CM, Sarkar PS and Hazra T (2012) Role of human DNA glycosylase Nei-like 2 (NEIL2) and single strand break repair protein polynucleotide kinase 3’-phosphatase in maintenance of mitochondrial genome, J. Biol. Chem., 287, 2819-2829; PMID: 22130663

Jones K., Jin B., Polina I., Huichalaf C., Sarkar P.S., Schneider-Gold C., Schoser B., Meola G., Shyu A.B., Timchenko N., Timchenko L. (2011): RNA Foci, CUGBP1, and ZNF9 Are the Primary Targets of the Mutant CUG and CCUG Repeats Expanded in Myotonic Dystrophies Type 1 and Type 2., Am J Pathol., PMID: 21889481

Zhao Y, Banerjee S, Dey N, Lejeune WS, Sarkar PS, Brobey R, Rosenblatt KP, Tilton RG, Choudhary S. (2011)  Klotho Depletion Contributes to Increased Inflammation in Kidney of the db/db Mouse Model of Diabetes via RelA (Serine)-536 Phosphorylation; Diabetes, 60 (7), 1907-1916

White MC, Gao R, Xu W, Mandal SM, Lim JG, Hazra TK, Wakamiya M, Edwards SF, Raskin S, Teive HA,  Zoghbi HY, Sarkar PS, Ashizawa T,(2010) Inactivation of hnRNP K by Expanded Intronic AUUCU Repeat Induces Apoptosis via Translocation of PKCδ to Mitochondria in Spinocerebellar Ataxia 10, PLoS Genetics, 6, e1000984; PMID: 20548952

Huichalaf C., Sakai K., Jin B., Wang Guo-Li, Schoser B., Schneider-Gold C., Sarkar PS, Olivia M. Pereira-Smith, Timchenko N., and Timchenko LT (2010) Expansion of CUG-RNA repeats causes stress and inhibition of translation in Myotonic Dystrophy, FASEB J., 24, 3706-3719. PMID: 20479119

Huichalaf C., Schoser B., Schneider-Gold C., Jin B., Sarkar PS, and Timchenko LT (2009) Reduction of the rate of protein translation in patients with myotonic dystrophy type 2, J. Neuroscience, 29, 9042-9049; PMID: 19605641

Salisbury E, Schoser B, Schneider-Gold C, Wang GL, Huichalaf C, Jin B, Sirito M, Sarkar PS, Krahe R, Timchenko NA, Timchenko LT. (2009) Expression of RNA CCUG Repeats Dysregulates Translation and Degradation of Proteins in Myotonic Dystrophy 2 Patients, Am. J. Pathol., 175, 748-762; PMID: 19590039

Banerjee D, Mandal SM, Das A, Hegde ML, Das S, Bhakat KK, Nogales E, Boldogh I, Sarkar PS, Mitra S, Hazra TK (2010), NEIL2-Initiated Preferential Repair of Oxidized Base Damage in the Transcribed DNA Strand, J.Biol. Chem, 286, 6086-16: PMID: 21169365

Sarkar PS, Paul S., Han J. and Reddy S, (2004) Six5 is required for spermatogenic cell survival and spermiogenesis, Human Molecular Genetics, 13(14), 1421-1431

Sarkar PS, Appakutan B, Han J, Ito Y, Ai C, Tsai W, Chai,Y, Stout JT, and Reddy S, (2000) Heterozygous loss of Six5 is sufficient to cause ocular cataract, Nature Genetics, 25, 110

Sarkar PS, Chang HC, Boudi FB, and Reddy S, (1998) CTG repeat show bimodal amplification in E.coli. Cell, 95, 531

Honors and Awards:

  • N/A

Professional Affiliations:

  • International myotonic dystrophy consortium (IDMC)
  • American Society for Human Genetics (ASHG)
  • International Myotonic Dystrophy Organization (IDMO)