1. Hernandez, C.M., Hogan, D., Song, W., Zheng, H., Sweatt, J.D, Dineley, K.T.,  (2007) Loss of alpha7 nicotinic receptors triggers cholinergic and hippocampal neurodegeneration in a mouse model of Alzheimer’s disease. Submitted: J. Neurosci.
2. Dineley, K.T., Hogan, D., Ru, W., Taglialatela, G. (2007) Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice.  Neurobiol. Learn. Mem.  In press.
3. Dineley, K.T., Ab peptide and nicotinic acetylcholine receptor interaction: The two faces of health and disease.  (2007) Frontiers in Bioscience: Nicotinic Acetylcholine Receptors in Adult and Developing Brain. 12: 5030-5038.

4.      Bell, K.A., O’Riordan, K.J., Sweatt, J.D. and Dineley, K.T.  (2004) MAPK recruitment by b-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time.  J. Neurochem.  91:349-361.

5.      Wang, R., Dineley, K.T., Sweatt, J.D. and Zheng, H. (2004) Presenilin 1 familial Alzheimer’s disease mutation leads to defective association learning and impaired adult neurogenesis.  Neurosci. 126:305-312

6.      Dineley, K.T., Bell K.A., Bui D., and Sweatt J.D. (2002) b-amyloid peptide activates a7 nicotinic acetylcholine receptors expressed in Xenopus oocytes.  J. Biol. Chem. 277:25056-25061.

7.      Dineley, K.T., Xia X., Bui D., Sweatt J.D. and Zheng H. (2002) Accelerated plaque accumulation, associative learning deficits and up-regulation of a7 nicotinic acetylcholine receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins. J. Biol. Chem. 277:22768-22780.

8.      Dineley, K.T., Westerman M., Bui D., Bell K., Hsiao Ashe K. and Sweatt J.D. (2001) Beta-amyloid activates the mitogen-activated protein kinase cascade through hippocampal a7 nicotinic acetylcholine receptors: in vitro and in vivo mechanisms related to Alzheimer’s disease. J. Neurosci. 21:4125-4133.

9.      Dineley, K.T., Weeber, E.J., Atkins, C.M., Adams, J.P., Anderson, A. and Sweatt, J.D. (2001) Leitmotifs in the biochemistry of LTP induction: amplification, integration, and coordination.  J. Neurochem. 77:961-971.

10. Dineley, K.T. and Patrick J. (2000) Molecular determinants of alpha7 nAChR surface expression. J. Biol. Chem. 275:13974-13985.

Current Projects:

1) Physiological role of Ab – nAChR Interaction in Health and Disease
2) Hyperinsulinemia as a Risk Factor for AD
3) Role of NF-kB Signaling Axis in Ab – Induced Cognitive Impairment
4) Calcineurin as a Mediator of Ab – Induced Cognitive Impairment
5) Mass-Spectrometry Identification of Therapeutic Targets in Early and Late AD
6) Proteome of Nicotine – Conditioned Context Associations