Kayed Laboratory

Our laboratory utilizes Biophysical and biochemical analyses, cell culture, animal models and human tissues. We constantly develop new methods and reagents. We are working on many exciting projects, listed below; we also work in collaboration with many laboratories at UTMB and other institutions.

Alzheimer’s related projects:

·   Tau oligomers and their role in AD, PD and neurodegenerative tauopathies.

·   Amyloid oligomers and annular protofibrils; Formation, toxicity and role in disease pathogenesis.

·   Immunotherapy for AD and PD and diabetes.

·   Early diagnostics of Alzheimer’s by measuring tau oligomer in biological fluids.

·   Screening for drug like molecules against different amyloid species.

·   Amyloid oligomers, structure and polymorphisms.

Other degenerative diseases:

·   Insulin and IAPP aggregation into toxic oligomers and their removal   immunotherapy.

·   Amyloidosis in human tissues and animal models, characterization and immunotherapy.

·   Prion oligomers formation, infectivity and their role in species variations.

Publications via PubMed