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Biotransformation
Publications Archive
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2004 Publications
Awasthi YC, Yang Y, Tiwari NK, Patrick B, Sharma A, Li J, Awasthi S.
2004 Sep 1. Regulation of 4-hydroxynonenal-mediated signaling by
glutathione S-transferases. Free Radic Biol Med37 (5):607-19.
Chen CS, Lin JT, Goss KA, He YA, Halpert JR, Waxman DJ. 2004 May.
Activation of the anticancer prodrugs cyclophosphamide and ifosfamide:
identification of cytochrome P450 2B enzymes and site-specific mutants
with improved enzyme kinetics. Mol Pharmacol65 (5):1278-85.
Davydov DR, Botchkareva AE, Kumar S, He YQ, Halpert JR. 2004 Jun 1. An
electrostatically driven conformational transition is involved in the
mechanisms of substrate binding and cooperativity in cytochrome
P450eryF. Biochemistry43 (21):6475-85.
Engle MR, Singh SP, Czernik PJ, Gaddy D, Montague DC, Ceci JD, Yang Y,
Awasthi S, Awasthi YC, Zimniak P. 2004 Feb 1. Physiological role of
mGSTA4-4, a glutathione S-transferase metabolizing 4-hydroxynonenal:
generation and analysis of mGsta4 null mouse. Toxicol Appl Pharmacol194
(3):296-308.
Heverin M, Bogdanovic N, Lutjohann D, Bayer T, Pikuleva I, Bretillon L,
Diczfalusy U, Winblad B, Bjorkhem I. 2004 Jan. Changes in the levels of
cerebral and extracerebral sterols in the brain of patients with
Alzheimer's disease. J Lipid Res45 (1):186-93.
Kaphalia BS, Mericle KA, Ansari GA. 2004 Oct 1. Mechanism of
differential inhibition of hepatic and pancreatic fatty acid ethyl ester
synthase by inhibitors of serine-esterases: in vitro and cell culture
studies. Toxicol Appl Pharmacol200 (1):7-15.
Levine-Fridman A, Chen L, Elferink CJ. 2004 Feb. Cytochrome P4501A1
promotes G1 phase cell cycle progression by controlling aryl hydrocarbon
receptor activity. Mol Pharmacol65 (2):461-9.
Li H, Wang J, Kaphalia B, Ansari GA, Khan MF. 2004 Mar 26. Quantitation
of acrolein-protein adducts: potential biomarker of acrolein exposure. J
Toxicol Environ Health A67 (6):513-24.
Mast N, Andersson U, Nakayama K, Bjorkhem I, Pikuleva IA. 2004 Aug 1.
Expression of human cytochrome P450 46A1 in Escherichia coli: effects
Arch Biochem Biophys428 (1):99-108.
Mericle KA, Kaphalia BS, Ansari GA. 2004 Apr 9. Modulation of fatty acid
methyl esters in rats pretreated with tri-o-tolyl phosphate. J Toxicol
Environ Health A67 (7):583-93.
Murtazina DA, Andersson U, Hahn IS, Bjorkhem I, Ansari GA, Pikuleva IA.
2004 Dec. Phospholipids modify substrate binding and enzyme activity of
human cytochrome P450 27A1. J Lipid Res45 (12):2345-53.
Pikuleva IA. 2004 Feb 27. Putative F-G loop is involved in association
with the membrane in P450scc (P450 11A1). Mol Cell Endocrinol215
(1-2):161-4.
Scott EE, Liu H, Qun He Y, Li W, Halpert JR. 2004 Mar 15. Mutagenesis
and molecular dynamics suggest structural and functional roles for
residues in the N-terminal portion of the cytochrome P450 2B1 I helix.
Arch Biochem Biophys423 (2):266-76.
Scott EE, White MA, He YA, Johnson EF, Stout CD, Halpert JR. 2004 Jun
25. Structure of mammalian cytochrome P450 2B4 complexed with
4-(4-chlorophenyl)imidazole at 1.9-A resolution: insight into the range
of P450 conformations and the coordination of redox partner binding. J
Biol Chem279 (26):27294-301.
Sharma R, Brown D, Awasthi S, Yang Y, Sharma A, Patrick B, Saini MK,
Singh SP, Zimniak P, Singh SV, Awasthi YC. 2004 May. Transfection with
4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads
to phenotypic transformation and immortalization of adherent cells. Eur
J Biochem271 (9):1690-701.
Sharma R, Singhal SS, Wickramarachchi D, Awasthi YC, Awasthi S. 2004 Dec
20. RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in
cancer cells: implications in drug resistance. Int J Cancer112
(6):934-42.
Sharma R, Yang Y, Sharma A, Awasthi S, Awasthi YC. 2004 Apr. Antioxidant
role of glutathione S-transferases: protection against oxidant toxicity
and regulation of stress-mediated apoptosis. Antioxid Redox Signal6
(2):289-300.
Yadav S, Singhal SS, Singhal J, Wickramarachchi D, Knutson E, Albrecht
TB, Awasthi YC, Awasthi S. 2004 Dec 28. Identification of
membrane-anchoring domains of RLIP76 using deletion mutant analyses.
Biochemistry43 (51):16243-53.
Yamaguchi Y, Khan KK, He YA, He YQ, Halpert JR. 2004 Jan. Topological
changes in the CYP3A4 active site probed with phenyldiazene: effect of
interaction with NADPH-cytochrome P450 reductase and cytochrome b5 and
of site-directed mutagenesis. Drug Metab Dispos32 (1):155-61.
Yang Y, Yang Y, Trent MB, He N, Lick SD, Zimniak P, Awasthi YC, Boor PJ.
2004 Apr. Glutathione-S-transferase A4-4 modulates oxidative stress in
endothelium: possible role in human atherosclerosis. Atherosclerosis173
(2):211-21.
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