UTMB

Department of Obstetrics & Gynecology

Contact

 

K. Sathish Kumar, D.V.M., Ph.D.
Assistant Professor
Department of Obstetrics and Gynecology

Office:
UTMB Ob/Gyn, Route 1062
University of Texas Medical Branch
301 University Boulevard,
MRB 11.104B
Galveston, Texas 77555-1062
P: 409-747-6699 F: 409-772-2261
E:
kusathis@utmb.edu

 

Our laboratory studies cardiovascular physiology with an emphasis on women's health. Our investigations seek to understand the mechanisms of normal cardiovascular adaptations of pregnancy as well as the mechanisms of impaired vascular responses in women with preeclampsia. We use human tissues and animal models to address vascular tone as regulated by factors such as nitric oxide, EDHF, prostacyclin, intracellular calcium, renin angiotensin system and MAP kinases. Moreover, we study abnormal placental development, vascularity, and function as potential mechanisms of fetal growth restriction.

Another area of research for our laboratory is the mechanism of sex steroids in their action on vascular and metabolic function. We study novel pathways of androgen and estrogen’s action on vascular and metabolic function. Androgen and estrogen replacement is now controversial in regard to cardiovascular and metabolic health in aged men and post-menopausal women. Understanding the beneficial/detrimental role of androgen and estrogen in the vascular and metabolic system will lead to the development of alternative therapeutic approaches to reduce vascular and metabolic disease in men and post-menopausal women. Moreover, we study the effect of androgens on vascular smooth muscle and endothelial cell function as a potential mechanism for vascular dysfunction in women with preeclampsia.

Complications in pregnancy may also influence cardiovascular and metabolic health in the offspring. Numerous epidemiological studies have found a direct association of the perinatal environment (usually reflected by low birth weight) and the occurrence of cardiovascular and metabolic diseases later in life. It is likely that adaptive responses to fetal/neonatal environmental stresses lead to permanent changes that negatively influence metabolic and cardiovascular health in adult life. Although we have shown that the onset and severity of vascular and metabolic dysfunction are different in growth restricted males and females, the mechanisms underlying these changes are not known. We use animal models to understand mechanisms for altered cardiovascular responses in pregnancies from an adverse maternal environment as well as assessing the male and female offspring from these pregnancies in various life stages (fetal, neonatal, young and aged adults as well as subsequent pregnancies).

EDUCATION

Master of Veterinary Sciences
Tamil Nadu Veterinary and Animal Sciences University, India

Doctor of Philosophy (Pharmacology and Toxicology)
Indian Veterinary Research Institute, Izatnagar U.P., India

 FELLOWSHIP

Southern University and A&M College, Baton Rouge, LA (Cardiovascular Pharmacology)

University of Texas Medical Branch, Galveston, TX (Reproductive Biology)

 

RESEARCH METHODS

We use a multidisciplinary approach to address our research questions: whole animal acute and chronic measurements of arterial pressure (telemetry, carotid catheter, tail cuff); vascular function studies using myography on isolated small arteries; cellular imaging, confocal, and light microscopic analyses; molecular approaches (including micro array, real time PCR, and Western blot analysis); and cell cultures of placental, endothelial, and smooth muscle cells to assess intracellular signaling mechanisms.

 

NATIONAL ORGANIZATIONS

American Heart Association 2011-Present
Developmental Origins of Health and Disease (DoHAD)  2011-Present
Society for Study of Reproduction2008-2010  
Society of Toxicology 2007- 2009      
North American Vascular Biology Organization2005- 2009      
Society of Free Radical Biology and Medicine 2005-2007

 

HONORS AND AWARDS

Best Postgraduate Student, Madras Veterinary College, Chennai, India, 1999. 

Best Student in the Subject of Pharmacology, Madras Veterinary College, Chennai, India, 1999.

Gold medal for excellence in Pharmacology, Madras Veterinary College, Chennai, India, 1999

National Eligibility Test for Lectureship, Agricultural Scientist Recruitment Board, Indian Council of Agricultural Research, New Delhi, India, 2002.

Senior Research Fellowship for graduate studies, Indian Council of Agricultural Research, New Delhi, India, 2002.

Nominated for “Young Investigator Award”, Society of Free Radical Biology and Medicine, Denver, CO, 2006.

Invited to present at the Annual Earth Week Program, Southern University and A&M College, Baton Rouge, LA, 2006.

Invited to contribute two book chapters to the Free Radicals and Antioxidant Protocols, for the Methods in Molecular Biology series, Humana Press, Totowa, NJ, 2007.

Excellence in Basic Science Research, Center for Interdisciplinary Research in Women’s Health (CIRWH), University of Texas Medical Branch, Galveston, TX, 2008.

Larry Ewing Memorial Travel award, 42nd Annual Meeting of the Society of Reproduction, Pittsburgh, PA, 2009

NIH Young Investigator award, Perinatal Research Honor Society, Avon, CO, 2010

President’s Presenter Award from Society for Gynecological Investigation (SGI) for mentoring meritorious research/presentation, San Diego, CA, 2011                      

International Society for the Study of Hypertension in Pregnancy invited to present at their Late Breaking Science session, Geneva, Switzerland, 2012

 

GRANTS

R01 HL119869 (Sathishkumar)    07/01/2013–06/30/2018; NHLBI
Sex-specific fetal programming of adult vascular dysfunction and hypertension

R03 HD069750 (Sathishkumar)   07/25/2011–06/30/2014; NICHD
Maternal Androgen Excess: Vascular and Placental Function and Fetal Consequences

Search PubMed Database for Dr. Sathish Kumar's Publications


 
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