Koyanagi Y, O'Brien WA, Zhao JQ, Golde DW, Gasson JC, Chen ISY: Cytokines alter production of HIV from primary mononuclear phagocytes.  Science 241:1673-1675, 1988.

     O'Brien WA, Koyanagi Y, Namazie A, Zhao J-Q, Diagne A, Idler K, Zack JA, Chen ISY: HIV-1 tropism   for mononuclear phagocytes can be determined by regions of gp 120 outside the CD4-binding domain.  Nature 348:69-73, 1990.

     Chesebro B, Nishio J, Perryman S, Cann A, O'Brien WA, Chen ISY, Wehrly K:  Identification of HIV envelope gene sequences influencing viral entry into CD4-positive HeLa cells, T-cell leukemia cells and   macrophages.  J Virol  65:5782-5789, 1991

     Pang S, Vinters HV, Akashi T, O'Brien WA, Chen ISY:  HIV-1 Env sequence variation in brain tissue of patients with AIDS encephalopathy.  J AIDS 4:1082-1091, 1991.

     Rich EA, Chen ISY, Zack JA, Leonard ML, O'Brien WA:  Increased susceptibility of differentiated mononuclear phagocytes to productive infection with human immunodeficiency virus type 1 (HIV-1).  J Clin Invest 89:176-183, 1992.

     Cann AJ, Churcher MJ, Boyd M, O'Brien WA, Zhao J-Q, Zack JA, Chen ISY:  The region of the envelope gene of HIV-1 responsible for determination of cell tropism.  J Virol 66:305-309,1992.

     Hamilton JD, Hartigan PM, Simberkoff MS, Day PL, Diamond GR, Dickinson GM, Drusano GL, Egorin MJ, George WL, Gordin FM, Hawkes CA, Jensen PC, Klimas NG, Labriola AM, Lahart CJ, O'Brien WA, Oster CN, Weinhold KJ, Wray NP, Ziegler JL, Zolla-Pazner SB, VA Cooperative Study Group on AIDS Treatment:  Early versus later zidovudine therapy for patients with symptomatic human immunodeficiency virus infection:  Results of a randomized, double-blind VA cooperative study.  New Engl J Med, 326:437-443, 1992.

     Sharpless NE, O'Brien WA, Verdin EM, Kufta CV, Chen ISY, Dubois-Dalcq M:  A primary determinant of immunodeficiency virus 1 (HIV-1) neurotropism resides in a region of the env glycoprotein that also controls monocyte-macrophage tropism.  J Virol, 66:2588-2593, 1992.

     O'Brien WA, Chen ISY, Ho DD, Daar ES:  HIV-1 resistance to soluble CD4 is conferred by domains of gp 120 that determine cell tropism.  J. Virol, 66:3125-3130, 1992.

     O'Brien WA, Namazi A, Mao S-H, Kalhor H, Zack JA, Chen ISY:  Kinetics of HIV-1 reverse transcription in Blood mononuclear phagocytes are slowed by limitations of nucleotide precursors. J Virol 68: 1258-1263, 1994.

     O'Brien WA, Mao S-H, Cao Y, Moore JP:  Macrophage and T-cell line-adapted HIV-1 strains differ in their susceptibility to neutralization by soluble CD4 at different temperatures.  J Virol, 68:5864-5269, 1994.

       Yu X, McLane MF, Ratner L, O'Brien WA, Collman R, Essex M, Lee T-H:  Direct killing of primary CD4+ T-cells by HIV-1.  Proc Natl Acad Sci, USA, 91:10237-10241, 1994.

     O'Brien WA, Grovit-Ferbas K, Namazi A, Ovcak-Derzic S, Wang H-J, Park J, Yeramian C, Mao S-H, Zack JA: HIV-1 replication can be increased in peripheral blood of seropositive patients after influenza immunization. Blood, 86:1082-1089, 1995

     O'Brien WA, Hartigan P, Martin D, Rubin M, Simberkoff MF, Hamilton J:  Changes in plasma HIV-1 RNA and CD4+ lymphocyte counts and the risk of progression to AIDS.  New Engl J Med, 334:426-431, 1996.

     O'Brien WA, Sumner-Smith M, Mao S-H, Sadeghi S, Zhao J-Q, Chen ISY: Anti-HIV-1 activity of an oligocationic compound is mediated via gp120 V3 interactions.  J Virol 70:2825-2831, 1996.

     Saag MS, Holodniy M, Kuritzkes DR, O’Brien WA, Coombs R, Poscher ME, Jacobsen DM, Shaw GM, Richman DD, Volberding PA: HIV viral load markers in clinical practice.  Nature Medicine 2:625-629, 1996.

      O’Brien WA, Hartigan PM, Daar ES, Simberkoff MS, Hamilton JD: The relationship of antiretroviral treatment-associated plasma HIV RNA and CD4 lymphocyte count changes over time.  Ann Intern Med 126:939-945, 1997.

     Doranz BJ, Grovit-Ferbas K, Goetz MB, Daar ES, Doms RW, O’Brien WA:  A small moleculer inhibitor directed against the chemokine receptor CXCR4 prevents its use as an HIV-1 coreceptor, J Exp Med, 186:1-6, 1997.

    Herbein G. and S. Gordon. 55-kDa and 75-kDa tumor necrosis factor receptors mediate distinct actions in regard to human immunodeficiHerbein, G., H. Sovalat, E. Wunder, M. Baerenzung, J. Bachorz, H. Lewandowski, C. Schweitzer, C. Schmitt, A. Kirn, and Ph. Henon. Isolation and identification of two CD34+ cell subpopulations from normal human peripheral blood. Stem Cells 1994, 12: 187-197.

    Herbein, G., S. Keshav, M. Collin, L.J. Montaner, and S. Gordon.  HIV-1 induces tumor necrosis factor and interleukin-1 gene expression in primary human macrophages independent of productive infection. Clin. Exp. Immunol. 1994, 95: 442-449.

    Montaner, L.J., A.G. Doyle, M. Collin, G. Herbein, P. Illei, W. James, A. Minty, D. Caput, P. Ferrara, and S. Gordon. Interleukin-13 inhibits human immunodeficiency virus type 1 production in primary blood-derived human macrophages in vitro. J. Exp. Med. 1993, 178: 743-747.

    Ott M., S. Emiliani, C. Van Lint, G. Herbein, J. Lovett, N. Chirmule, T. McCloskey, S. Pahwa, and E. Verdin. Immune hyperactivation of HIV-1-infected T cells mediated by Tat and the CD28 pathway. Science (Wash. DC) 1997; 275:1481-1485.

    Herbein G. Cytokines, viruses and macrophages: an interactive network. - An immune dysregulation involving the members of the tumor necrosis factor (TNF) receptor superfamily could be critical in AIDS pathogenesis. Path. Biol. 1997; 45: 115-125.

    Herbein, G., L.J. Montaner, and S. Gordon. Tumor necrosis factor a inhibits entry of human immunodeficiency virus type 1 into primary human macrophages: a selective role for 75-kDa receptor. J. Virol. 1996; 70: 7388-7397.

    Karsten, V., Gordon S., Kirn A. and G. Herbein. HIV-1 envelope glycoprotein gp120 downregulates CD4 expression in primary human macrophages through induction of endogenous tumor necrosis factor alpha. Immunology 1996; 88: 55-60.

    Herbein, G., A.G. Doyle, L.J. Montaner, and S. Gordon. Lipopolysaccharide downregulates CD4 expression in primary human macrophages through induction of endogenous tumor necrosis factor (TNF) and interleukin-1b. Clin. Exp. Immunol. 1995; 102: 430-437.

    Montaner, L.J., G. Herbein, and S. Gordon. Regulation of macrophage activation and HIV replication. Adv. Exp. Med. Biol. 1995; 374: 47-56.
 

Book Chapters

     O'Brien WA, Koyanagi Y, Chen ISY: Virologic aspects of AIDS and the nervous system, in Neuropathology of AIDS, Vinters HV, Anders KH (eds).  CRC Press, Philadelphia PA, 1990, pp. 189-207.

    O’Brien WA, Pomerantz RJ:  AIDS and other diseases due to HIV infection.  In: Viral Pathogenesis. Nathanson N (ed) Lippincott-Raven Press, Philadelphia, PA, 1997, 815-863.

     Grovit-Ferbas K, Pappas T, O'Brien WA: Human immunodeficiency viruses.  In: Persistent Viral Infections, Chen ISY and Ahmed R (eds) John Wiley & Sons, New York, NY, 1997, in press.
 
     Montaner, L.J, M. Collin, and G. Herbein. Human monocytes: isolation, cultivation, and applications. In: Hanbook of Experimental Immunology (5th edition), The myeloid system, Weir D.,  Herzenberg L., Blackwell C., Herzenberg L., eds, Blackwell Press, Boston, 1997, vol. IV, sect.26, chapt 155, p155.1-155.11.

    Collin, M., L.J. Montaner, G. Herbein, and S. Gordon. HIV infection of macrophages.  In HIV-1: Practical Approach; Balkwill F.R. ed, IRL Press, Oxford University Press, Oxford, 1995, p. 63-75.

    Montaner, L.J., Herbein, G., and S. Gordon. Regulation of macrophage activation and HIV replication. In Cell activation and apoptosis in HIV infection. Plenum Press, 1995, p. 47-56.

    Wunder, E., G. Herbein, H. Sovalat, and A. Kirn. Separation of hematopoietic cells of different maturity in mononuclear cell subsets generated by elutriation. In: Hematopoietic Stem Cells, The Mulhouse Manual; Henon P., Wunder E., Sovalat H., S. Serke, eds, Alpha Medical Press, Dayton, OA, 1994, p. 271-279.

    Montaner, L.J., Herbein, G., and S. Gordon. Proinflammatory, TH1 and TH2 cytokine regulation of HIV-1 in macrophages. In: Chalenges of Modern Medicine Vol 8, Cytokines: basic principles and practical applications. Romagnani S., Del Prete G., Abbas AK. (eds), Ares-Serono Symposia Publications, Rome, Italy, 1994, p. 203-208.