Musculoskeletal Physiology and Histomorphometry Laboratory
Faculty and Personnel
Zbigniew Gugala, MD, PhD
Overview and Facilities
Research is focused on the endocrinological and nutritional factors which influence the pace on
bone turnover, and how those factors can be modulated by environmental factors/cues (light-dark cycle,
feeding schedule, etc.) which play an important role in physiologic and pharmacologic behavior of skeletal tissue cells.
Work in the laboratory has also involved the physiology of fracture/wound healing, alkaline earth metabolism in
laboratory animals and biomaterials such as charged resins. We seek to understand the interrelationships between bone
and marrow cells which appear to play such an important role in the development of osteoporosis and other metabolic bone diseases.
- Bone turnover and remodeling
- Marrow stromal cells
- Electrically charged dextran resins
- Lumbar vertebral instability (animal and human models)
- Biomaterials for vertebral body fusion
- Fracture healing and the effect of cytokines