UTMB MoLMeL
    Vicente A. Resto, M.D., Ph.D.
 

Our Research Focus

Our laboratory focuses on the study of lymphatic metastasis with special interest in the molecular mediators of lodgment and growth of tumor cells within the lymph node microenvironment. Furthermore, we are interested in understanding the impact these interactions have towards promoting tumor tolerance by the immune system. To these ends we apply functional genetic screening, biophysical, and biochemical techniques to the study of this novel biology.

Ongoing projects:

One Biochemical analysis of L-selectin ligands active under low shear stress

Two Biochemical analysis of receptors expressed on human lymphocytes that are important for low shear stress dependent binding to cancer cells

Three Functional genetic analysis of determinants important for L-selectin ligand expression in cancer

Four Functional genetic analysis of determinants important for E-selectin ligand expression in cancer

Lab Members
Link Vicente A. Resto, M.D., Ph.D., Principle Investigator
Link Susan M. Fennewald, Ph.D., Senior Research Associate
Link Tovë M. Goldson, M.D., Ph.D., Postdoctoral Fellow

Links
 UTMB
Link Moody Medical Library
Link Sealy Center for Cancer Cell Biology (SCCCB)
Link SCCCB Research in Progress Fall 2006 Seminar Series
Link Core Facilities


 External
Link Entrez PubMed
Link Human Protein Reference Database
Link Immunohistochemistry World

  Cancer Cells
enter lymph nodes via afferent lymphatic vessels.
  Lymph Node
Lymphocytes and Cancer Cells
interact under low shear stress.
 
 

 University of Texas
 Medical Branch
 301 University Boulevard
 Galveston, TX 77555-1063
 Tel: 409-772-2699
 Fax: 409-772-2694
 varesto@utmb.edu

 Last Modified: 10/12/2006

 

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