Resto Laboratory - Home Page


	Vicente A. Resto, M.D., Ph.D.

UTMB Home Laboratory Home Department of Otolaryngology Otolaryngology Faculty Department of Biochemistry and Molecular Biology Graduate School of Biomedical Sciences Cell Biology Graduate Program Cancer Cell Biology Track Experimental Pathology Graduate Program	Our Research Focus Our laboratory focuses on the study of lymphatic metastasis with special interest in the molecular mediators of lodgment and growth of tumor cells within the lymph node microenvironment. Furthermore, we are interested in understanding the impact these interactions have towards promoting tumor tolerance by the immune system. To these ends we apply functional genetic screening, biophysical, and biochemical techniques to the study of this novel biology. Ongoing projects: Biochemical analysis of L-selectin ligands active under low shear stress Biochemical analysis of receptors expressed on human lymphocytes that are important for low shear stress dependent binding to cancer cells Functional genetic analysis of determinants important for L-selectin ligand expression in cancer Functional genetic analysis of determinants important for E-selectin ligand expression in cancer Lab Members Vicente A. Resto, M.D., Ph.D., Principle Investigator Susan M. Fennewald, Ph.D., Senior Research Associate Tovë M. Goldson, M.D., Ph.D., Postdoctoral Fellow Links UTMB Moody Medical Library Sealy Center for Cancer Cell Biology (SCCCB) SCCCB Research in Progress Fall 2006 Seminar Series Core Facilities External Entrez PubMed Human Protein Reference Database Immunohistochemistry World	Cancer Cells enter lymph nodes via afferent lymphatic vessels.
		Lymphocytes and Cancer Cells interact under low shear stress.

University of Texas Medical Branch 301 University Boulevard Galveston, TX 77555-1063 Tel: 409-772-2699 Fax: 409-772-2694 varesto@utmb.edu
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