Jianli Dong, M.D., Ph.D.Jianli Dong, MD, PhD, FACMG

Professor,
Director, Molecular Diagnostics Division ,
Department of Pathology;

Office: (409) 772-4866
Fax: (409) 772-5683
Pager (409) 943-3258
jidong@utmb.edu

 

Division of Molecular Diagnostics

Welcome to the Molecular Diagnostics Division web page. The Division of Molecular Diagnostics provides timely and accurate assays for nucleic acid targets found in settings of germline and somatic genetics, and infectious diseases. The Division is staffed with 8 core FTEs who perform over 20,000 tests annually. We are open Monday-Friday, 8 am-5 pm.

The Molecular Diagnostics Division uses a variety of nucleic acid assays including a range of extraction methods, qualitative and quantitative PCR, Sanger and pyrosequencing, membrane and fluorescent in situ hybridization, hybrid capture, and whole genome SNP microarray. Our test menu is listed below with more information in the Lab Survival Guide: http://www.utmb.edu/lsg/. Additional tests are continuously evaluated to bring in house and input from clinical providers is welcome.

MOLECULAR DIAGNOSTICS TESTS:

Inherited and Somatic Genetic Diseases:

  • Cystic fibrosis 32 mutations
  • Whole genome SNP microarray
  • Factor 5 mutation
  • Prothrombin (Factor 2) mutation
  • Hyperhomocysteinemia (MTHFR) C677T, A1298C mutations
  • BRAF V600 mutations
  • KRAS codons 12, 13, 61 mutations
  • HER2/ERBB2 DNA fluorescent in situ hybridization

Infectious Diseases:

  • BK viral load quantification
  • CMV viral load quantification
  • Hepatics B viral DNA quantification
  • Hepatitis C viral RNA quantification
  • Hepatitis C virus genotyping
  • Detection of high risk HPV (Digene and SurePath)
  • HIV-1 viral load quantification
  • HIV-1 drug resistance mutation analysis

The Division of Molecular Diagnostics serves as a rotation/elective site for medical technologists, medical students, residents, and fellows to become familiar with fundamentals of molecular biology in clinical diagnostics. Trainees gain experience with laboratory activities including selection of tests and methods, processing and analysis of various types of specimens, and interpretation and reporting of test results.