My research will focus on determining the mechanism and functions of nonstructural protein 1 of coronaviruses.
I am interested in ticks and tickborne diseases, specifically tick borne encephalitis and spotted fever group Rickettsia infections. I am working in Dr. Walker's laboratory studying tick transmission of Rickettsia massiliae and the early immune events following infection.
|Andrew S. Beck
Pathogenesis of yellow fever disease, determinants of attenuation for the yellow fever vaccine strain 17D-204
|Nicholas A. Bergren
My primary area of research interest is geared towards developing novel, safe, and efficacious vaccine candidates for emerging infectious diseases primarily by way of genetic modification of the virus. I also am interested in studying mechanisms of virulence and attenuation in vitro and in vivo, and would ultimately like to elucidate genetic determinants of virulence. A comprehensive understanding of viral genetics will allow the scientific community to better understand pathogenic mechanisms and as a result develop more effective vaccines and therapeutics.
|Veronica E. Calderon
My research interests include Mycobacterium tuberculosis, and my research will involve the effects of the P2X7 receptor and activation of effector T cells during M. tb. autophagy.
My research will focus on the role of neutrophil in the pathogenesis of inflammatory bowel disease (IBD) and how neutrophil interact with microbiota.
|Erika C. Gomez, M.Sc.
Study of the mechanisms involved in the immuno-pathobiology of human diseases, adherence and colonization mechanisms, inflammatory immune response, immune effector mechanisms, and immune regulation.
|Meghan E. Hermance
My research will focus on the tick-borne flavivirus, Deer tick virus (DTV), and its natural vector, Ixodes scapularis. The long term goal of my research is to study the early host immune response to tick-borne flaviviruses. I will additionally investigate how I. scapularis endosymbionts influence the vector competence of DTV.
|Olga A. Kolokoltsova
Arenavirus pathogenesis and virus-host interaction
I am interested in novel immune cell signaling pathways that regulate inflammation during infection with pathogens. My research will focus on the metabolism of macrophages that enhance the pro-inflammatory capacity to clear the etiologic agent of Chagas cardiomyopathy, Trypanosoma cruzi.
|Jessica A. Lewis
My work focuses on domain III of the flavivirus envelope protein.
|Brian R. Mann
My research focus is on the molecular epidemiology and pathogenesis of West Nile virus. My dissertation research considers the role of the West Nile virus non-structural proteins in antagonism of the innate immune response in acute human infection.
|John T. Manning
My goal is to investigate different attenuating factors within the genomes of New World arenaviruses in order to develop attenuated live vaccine candidates.
|Sandra V. Mayer
My research interest is to study dengue pathogenesis in a humanized mouse model.
My research interests are characterizing novel Arboviruses utilizing both in vitro and in vivo models.
|Michael J. Patterson
I am interested in arenavirus pathology, with specifics to Junin and the factors leading to persistence and neurological disease development in late stage infection.
I started my Ph.D. study on Rift Valley fever virus (RVFV) in particular for the vaccine development. The overall aim of my Ph.D. study is to develop highly safe candidate vaccine which specifically target DC, and the spread is restricted after infection.
Currently I am in the process of developing a live attenuated vaccine candidate for chikungunya virus (CHIKV).
|Sydney I. Ramirez
The current focus of my research is to study the mechanism(s) by which the nsp1 protein of coronaviruses inhibits translation, and to examine its role in viral virulence and pathogenesis.
My research lab focuses on neurological sequelae resultant alphavirus and arenavirus infections.
I am interested in Rickettsia spp and host endothelial cell interactions. I am examining Rickettsia spp use of type IV secretion systems.
My research interests are focused on the molecular mechanisms underlying the high pathogenicity of hemorrhagic arenaviruses.
|Thomas R. Shelite
My research interest includes determining the mechanisms of immunity and pathogenesis of scrub typhus infection and development of relevant animal models.
|Jesus A. Silvas
My main interest lies in understanding the molecular pathogenesis of emerging viral diseases. Currently, my research is focused on understanding how a novel virus, Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV), counteracts the innate immune response.
My research will focus on protective innate immune mechanisms of the host in response to rickettsial infection.
|Stephan P. Willias
My prior experience has facilitated the progression to my current scope of research which focuses on Yersinia pestis metabolic reprogramming amidst host transitions. Specifically, I seek to ascertain the impact of regulatory elements upon the Y. pestis infectious process.
|Evandro R. Winkelmann
My research interests focus mainly on viral immunology and vaccinology.
I study infectious diseases like Rickettsia and Dengue. I not only comprehensively inspect the pathogens, but also investigate the response of host immunity.
Jere W. McBride, Ph.D.
Professor, Department of Pathology
Center for Biodefense and Emerging Infectious Diseases
Sealy Center for Vaccine Development
Director, Experimental Pathology Graduate Program
Office: (409) 747-2498
Fax: (409) 747-2455