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Dr. Ansari

Ghulam Ahmad Shakeel Ansari, Ph.D.

Professor, Department of Biochemistry & Molecular Biology;
Professor, Department of Pathology;
Co-Director, Integrative Health Science Facility Core, National Institute for Environmental Health & Sciences Center;
Member, Sealy Center for Environmental Health and Medicine

The University of Texas Medical Branch at Galveston
301 Univesity Boulevard
Galveston, TX  77555-0438

Office: (409) 772-3107
Fax: (409) 772-9679
Office: (409) 772-3655
Fax: (409) 747-1763
sansari@utmb.edu

Professional Education

Degree Institution Field of Study Graduation Year
B.S.

Aligarh Muslim University, Aligarh, India

 Chemistry 1966
M.S. Aligarh Muslim University, Aligarh, India Chemistry 1969
Ph.D. Aligarh Muslim University, Aligarh, India Chemistry 1973

Honors

1992–Present Associate Editor, Bulletin of Environmental Contamination and Toxicology
2000 Co-Chaired a session entitled, “Cellular Toxicity” at 3rd WorldCongress on Cellular and Molecular Biology, Jena, Germany
2003 Received “Researcher of the year” award from Department of Pathology, UTMB
2007–Present Issue Editor, Encyclopedia of Environmental Health
Editorial Boards
1988–Present Journal of Toxicology and Environmental Health
2000–Present Toxicology and Applied Pharmacology

Professional Affiliations

1975–Present American Chemical Society
1985–Present American Society of Biochemistry and Molecular Biology*
1985–Present Society of Toxicology*
1989–Present International Society for the Study of Xenobiotics*
2008–Present Association for study of Lime Disease

Research Interests

  • Molecular Toxicology
  • Biomarker Signatures
  • Metabolomics
  • Chemical-mediated Autoimmunity
  • Chemical-mediated Liver Injury
  • Systems Biology

Selected Publications

  1. Cai, P., Konig, R., Boor, P. J., Kondragant, S., Kaphalia, B.S., Khan, M.F., Ansari, G.A.S.  Chronic exposure to trichloroethene causes early onset of SLE-like disease in female MRL +/+ mice.  Toxicol. Appl. Pharmacol. 228:68-75, 2008.
  2. Konig, R., Cai, P., Guo, X., Ansari, G.A.S.  Transcription analysis reveals early signs of liver toxicity in female MRL/mice exposed to the acylating chemicals dichloroacetyl chloride and dichloroacetic anhydride. J. Chem. Res. Toxicol. 21:572-582, 2008.
  3. Cai, P., König, R., Khan, M.F., Kaphalia, B.S., Ansari, G.A.S.  Differential immune responses to albumin adducts of reactive intermediates of Trichloroethene in MRL +/+ mice. Toxicol. Appl. Pharmacol. 220:278–283, 2007.
  4. Wu, H., Cai, P., Clemens, D.L., Jerrells, T.R., Ansari, G.A.S., Kaphalia, B.S.  Metabolic basis of ethanol induced cytotoxicity in recombinant HepG2 cells: Role of nonoxidative metabolism. Toxicol. Appl. Pharmacol. 216:238-247, 2006.
  5. Sharma, R., Ansari, G.A.S. and Awasthi, Y.C.  Physiological substrates of glutathione S-transferases. “Toxicology of Glutathione Transferases,” Chapter 9 (Y.C. Awasthi, Editor), CRC Press (2006).
  6. Cai P., Kaphalia, B.S., Ansari, G.A.S.  Methyl palmitate: Inhibitor of phgocytosis in primary rat Kupffer Cells. Toxicology, 210:197-204, 2005.
  7. Mericle, K.A., Kaphalia, B.S., Ansari, G.A.S.  Modulation of fatty acid methyl esters in rats pre-treated with tri-o-tolyl phosphate.  J. Toxicol. Environ. Health, Part A 67:583-593, 2004.
  8. Green, S.M., Khan, M.F., Kaphalia, B.S., Ansari, G.A.S.  Immnohistochemical localization of protein adducts of tetrachloreoethene in mice.  J. Toxicol. Environ. Health 63:  145-157, 2001.
  9. Kaphalia BS, Fritz RR and Ansari GAS. Purification and characterization of rat liver microsomal fatty acid ethyl and 2-chloroethyl ester synthase and their relationship with carboxylesterase (Pl 6.1). Chem. Res. Toxicol. 10:211-218, 1997.
  10. Awasthi YC, Zimniak P, Awasthi S, Singhal SS, Srivastava SK, Piper JT, Chaubey M, Petersen DR, He N, Sharma R, Singh SV, Khan FM, Ansari GAS, Boor PJ.  A new group of glutathione S-transferase with protective role against lipid peroxidation.  Glutathione s-transferases: structure, function and clinical implications. (Vermeulen et al., editors; Taylorand Francis, 1996) pages 111-124.
  11. Ansari GAS, Kaphalia BS, Khan MF.  Fatty acid conjugates of xenobiotics. (invited review) Toxicol Lett 75:1–17, 1995.
    Kaphalia BS, Carr JB, Ansari GAS.  Increased endobiotic fatty acid methyl esters following exposure to methanol.  Fundam Appl Toxicol. 28:264-273, 1995.
  12. Khan MF, Kaphalia BS, Prabhakar BS, Kanz MF, Ansari GAS.  Trichloroethene - induced autoimmune response in female MRL +/+ mice. Toxicol Appl Pharmacol 134:155-160, 1995.
  13. Ansari GAS, Smith LL.  Assay of cholesterol oxidation.  Methods Enzymol. 233: 332–338, 1994.
    Kanz MF Kaphalia L, Kaphalia BS, Ramagnoli E, Ansari GAS.  Methylene dianiline: Acute toxicity and effect on biliary function.  Toxicol. Appl. Pharmacol. 117:89–92, 1992.
  14. Boor PJ, Khan MF, Kaphalia BS, Jerrells TR, Ansari GAS.  Synergistic vascular toxicity and fatty acid anilides in the toxic oil syndrome.  J Am Coll Cardio 18: 1824-1828; 1991.
  15. Bhat HK, Ansari GAS.  Cholesterol ester hydrolase mediated conjugation of haloethanols with fatty acids. Chem Res Toxicol 3: 311-317;1990.
  16. Ansari GAS, Kaphalia BS, Boor PJ. Selective pancreatic toxicity of palmitoylpentachlorophenol.  Toxicology 46: 57-63; 1987.
  17. Ansari GAS, Smith LL.  High performance liquid chromato­graphy of cholesterol autoxidation products. J Chromatogr 175: 307-315; 1979.
  18. Ahmad MS, Ansari GAS.  Mass spectral studies on steroidal compounds-I, steroidal 6–one ethylene acetals. Org Mass Spectrom 6: 1095–1108; 1973.

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