Ahmed El-Sayed Ahmed, Ph.D.

Ahmed El-Sayed Ahmed, Ph.D.

Professor, Departments of Pathology, Pharmacology and Toxicology, Preventive Medicine and Community Health

University of Texas Medical Branch
301 University Boulevard
Galveston, TX 77555-0609

Office: (409) 772-2877
Fax: (409) 747-1763
aahmed@utmb.edu

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Ahmed El-Sayed Ahmed, Ph.D.

Professional Education

Degree Institution Field of Study Graduation Year
B. Pharm. & Pharm. Sci. College of Pharmacy, Cairo University, Cairo, Egypt Pharmacology 1966
Ph.D. College of Pharmacy, University of Minnesota, Minneapolis, MN Medicinal Chemistry 1975
Post-Doctoral Fellow College of Medicine, University of Minnesota, Mpls, MN   1975
Summer Fellow Massachusetts Institute of Technology, Boston, MA   1978
Swedish Medical Research Council Fellow Department of Toxicology, University of Uppsala, Uppsala, Sweden   1982-1983

Honors

- Honorary Professor, Cairo University, Cairo, Egypt
1964 Achievement Award of Pharmaceutical Sciences, Egypt
1971-1973 Melondy Fellowship Award, University of Minnesota
1975 NIH Postdoctoral Fellowship Award, University of Minnesota
1975-1977 NIH, National Research Service Award
1982-1983 Swedish Medical Research Council Fellowship Award
2007-2009 Member at Large ; Board of Directors; Association of Muslim Social Scientists

Professional Affiliations

  • Organizing Committee on Environment and Primary Health Care
  • New York Academy of Science
  • Southwest Oncology Group
  • Rho Chi Pharmaceutical Society
  • American Association for the Advancement of Science
  • American Pharmaceutical Association
  • Society of Environmental Toxicology and Chemistry - elected
  • Sigma Xi The Scientific Research Society - elected
  • UTMB Cancer Center
  • American Association of Cancer Research - elected
  • Society of Toxicology - elected
  • American Society for Pharmacology and Experimental Therapeutics - elected
  • International Society of Study of Xenobiotics - elected
  • American Society for Investigative Pathology - elected (local laison officer)

Research Interests

In the past three decades my colleagues and I focused our research efforts on the impact of chemicals in the environment on human health and its mechanisms. We received NIH grants, conducted research and published the results of our investigations in the appropriate journals. We wrote review and book chapters to express our opinion and current understandings in the field environmental toxicology as related to current and preceding findings in our laboratory. Recent epidemiologic studies indicated that chronic exposure to drinking water disinfectant byproducts (DBP) induce adverse pregnancy outcome including intra uterine fetal growth restriction (IUGR). Lately we investigated the effect of chemicals, such as DBPs, at environmentally relevant levels on fetal development including IUGR.

We acquired, in our laboratory, several preliminary evidences that support the initiation of IUGR in animal models exposed to DPBs. Furthermore, we identified that oxidative stress and chemically-induced reactive oxygen species play a major role in the mechanisms of such adverse activities.

Recent clinical evidences (Free Radicals Research, 41,870-873, 2007), have supported our theories and hypothesis and have detected that oxidative stress (induced environmentally and other wise) in uterine environment is the major cause of IUGR in pregnant women.

Selected Publications

  1. AHMED AE, Aronson J, Jacob S: Dichlonacetonitrile; a water disinfectant by-product induces oxidative stress as the mediator of apoptosis or necrosis in mouse peritoneal macrophages; Toxicology in vitro., 14,199-210,2000 .
  2. Chen K-H, Sreevastava K, Singhal RK, Jacob S, AHMED AE, Wilson SH: Modulation of base excision repair by low density lipoprotein, oxidized low density lipoprotein and antioxidants in mouse monocytes. Carcinogenesis. 21,106-110, 2001.
  3. Jacob S, AHMED AE: Acrylonitrile induces oxidative stress and 8-hydroxydeoxyguanosine formation in normal human astrocytes. Toxicology Mechanisms & Meth, 13, 169-179, 2003.
  4. Jacob S, and AHMED AE, Effect of route of administration on the Disposition of Acrylonitrile: Quantitative Whole Body Autoradiographic Study in Rats, Pharmacological Research, 48, 479-488, 2003
  5. S. Jacob and AHMED AE. Species Difference In The Disposition Of Acrylonitrile: Quantitative Whole Body Autoradiographic Study In Rats And Mice. Toxicology and Industrial Health 20, 9-19, 2004.
  6. AHMED AE, G. B. Campbell and *S. Jacob Neurological Impairment In Fetal Mouse Brain By Drinking Water Disinfectant Byproducts. NeuroToxicology 26, 533-64, 2005.
  7. AHMED AE., Jacob Sam, Campbell Gerald A., Harirah Hassan M., Perez-Polo, J. Regino, Johnson, Kenneth M., Fetal origin of adverse pregnancy outcome: The water disinfectant by-product chloroacetonitrile induces oxidative stress and apoptosis in mouse fetal brain, Development Brain Research, 190, 1-11, 2005.
  8. AHMED AE., El Mazar, H. Influence of Drinking Water Disenfetion by products, Kaser Aini Medical Journal. 29, 1-9, 2005
  9. S. Jacob, B. S. Kaphalia, N. Jacob and AHMED AE. The Water Disinfectant Byproduct Dibromoacetonitrile Induces Apoptosis in Rat Intestinal Epithelial Cells: Possible Role of Redox Imbalance; Toxicology Mechanisms and Methods,. 16, 1-8, 2006.
  10. M. Khalil, R. Mostafa and AHMED AE, Clinical Evaluation of 1,3 Butadiene Neurotoxicity, J. Tox and Industrial Health, 2007, 23,141.
  11. Ahmed A., Jacob S., Nagy A and Abdul Naim A., “Dibromoacetonitriles-Induced Protein Oxidation and Inhibition of Proteasomal Activities in Rat Glioma Cells”, Toxicology Letters,179, 29-33, 2008.
  12. Ahmed AE, El-Mazar HM, Nagy AA and Abdel-Naim AB. “Chloroacetonitrile Induces Intrauterine Growth Restriction and Musculo-Skeletal Toxicity in Fetal Mouse” J. Tox and Industrial Health, 24, 511-518, 2008.
  13. Lipscomb J, El-demerdash E., AHMED AE.,., Haloacetonitrile, Toxicity and Carcinogenicity. Review of Environmental Contaminants and Toxicology, 2009. 198, 169-200, 2009.
  14. Ashraf B Abdel-Naim, Ayman A. Nagy, Ahmed M Mohamadin, Hala M Elmazar, Ahmed AE "Chloroacetonitrile induces oxidative stress and apoptosis in mouse fetal liver" 2009, Toxicology Letters, In press

Additional Biographical Information