Gerald A. Campbell, M.D., Ph.D.
||Field of Study
||University of Kentucky, Lexington
||Physics and Mathematics
||University of Texas, Austin
||University of.Texas Southwestern Medical School, Dallas
||Lab of Neuropharmacology, NIMH, St. Elizabeth’s Hospital, Washington, D.C.
||Lab of Preclinical Studies, NIAAA, Rockville, MD
|Duke University Medical Center, Durham, NC
||Anatomic Pathology and Neuropathology
- Phi Beta Kappa
- Woodrow Wilson Foundation Honorary Fellow
- National Science Foundation Fellow in Physics
- Sigma Xi
- AANP - American Association of Neuropathologists
- ISN - International Society of Neuropathology
- ASIP - American Society for Investigative Pathology
- CAP - College of American Pathologists
- ASCP - American Society of Clinical Pathologists
- TSP - Texas Society of Pathologists
- AAAS - American Society for the Advancement of Science
- TMS - Texas Medical Society
- Galveston County Medical Society
- American Physical Society
Current interests are focused on the role of blood-brain barrier in the pathogenesis of cerebral small vessel disease and vascular dementia. Pathologic disruption of blood-brain barrier function by both chemical and cellular mediators alters the protected environment of the central nervous system (CNS), resulting in dysfunction and injury in a number of disease conditions. Normal blood-brain barrier function is essential to isolate the CNS from the chemical and immunologic environment of the peripheral vascular system. Physiologic regulation of blood-brain barrier permeability maintains a stable ionic environment in the CNS while permitting the entry of nutrients and precursor molecules and removal of waste materials and metabolites, but blocks the entry of harmful endogenous or exogenous blood-borne agents and severely restricts transmigration of blood leukocytes. The goal of my current work is to characterize substances deposited in brain vessel walls through leakage of plasma components across the endothelial barrier and to study the reactive processes that may be incited by such deposition. Most current work concentrates on the study of human tissue obtained from autopsies, but studies of specific mechanisms in spontaneously hypertensive, stroke prone rats are also planned.
I also have an interest in brain injury in chronic alcoholism, and I participate in collaborative studies on neuropathology of viral encephalitis, neuromuscular disease, cerebrovascular disease, genetic brain disease and toxicology with other investigators in pathology, neurology, medicine, pediatrics, biochemistry and ophthalmology.
- Gasco, J.; Franklin, B.; Rangel-Castilla, L.; Campbell, G.A.; Eltorky, M.; Salinas, P. Primary angioleiomyoma of the cerebellum: A new location for a rare entity. Case report and literature review. J. Neurosurg. 110:670-4; 2009 [Epub 2008 Nov 14]
- Duarte, A.G.; Terminella, L.; Smith, J.T.; Myers, A.C.; Campbell, G.A.; Lick, S. Restoration of cough reflex in lung transplant recipients. Chest 134:310-16; 2008 [Epub 2008 Mar 13]
- Hauck, E.F.; Vu, L.; Campbell, G.A.; Nauta, H.J. Intraventricular ganglioglioma. J. Clin. Neurosci. 15:1291-3; 2008
- Paessler, S.; Yun, N.E.; Judy, B.M.; Dziuba, N.; Grund, A.H.; Zacks, M.A.; Frolov, I.; Campbell, G.A.; Weaver, S.C.; Estes, D.M. Alpha-beta T cells provide protection against lethal encephalitis in the murine model of VEEV infection. Virology 367:307-23; 2007 [Epub 2007 Jul 5]
- Matalon, R.; Surendran, S.; Campbell, G.A.; Michals-Matalon, K.; Tyring, S.K.; Grady, J.; Cheng, S.; Kaye, E. Hyaluronidase increases the biodistribution of acid alpha-1,4 glucosidase in the muscle of Pompe disease mice: An approach to enhance the efficacy of enzyme replacement therapy. Biochem. Biophys. Res. Commun. 350:783-7; 2006 [Epub 2006 Oct 2]
- Schneider, B.S.; Soong, L.; Girard, Y.A.; Campbell, G.A.; Mason, P.; Higgs, S. Potentiation of West Nile encephalitis by mosquito feeding. Viral Immunol. 19:74-82; 2006
- Surendran, S.; Campbell, G.A.; Tyring, S.K.; Matalon, R. Aspartoacylase gene knockout results in severe vacuolation in the white matter and gray matter of the spinal cord in the mouse. Neurobiol. Dis. 18:385– 389; 2005
- Holbrook, M.R.; Aronson, J.F.; Campbell, G.A.; Jones, S.; Feldmann, H.; Barrett, A.D.T. An animal model for the tick-borne flavivirus Omsk hemorrhagic fever virus. J. Infect. Dis. 191:100-8; 2005
- Peng, B.H.; White, M.A.; Campbell, G.A.; Robert, J.J.; Lee, J.C.; Sutton, R.B. Crystallization and preliminary X-ray diffraction of the ZO-binding domain of human occludin. Acta Cryst. F61:369-371; 2005
- Ahmed, A.E.; Campbell, G.A.; Jacob, S. Neurological impairment in fetal mouse brain by drinking water disinfectant byproducts. Neurotoxicol. 26:633-640; 2005
- Ahmed, A.E.; Jacob, S.; Campbell, G.A.; Hassan, H.M.; Perez-Polo, J.R.; Johnson, K.M. Fetal Origin of Adverse Pregnancy Outcome: The Water Disinfectant Byproduct Chloroacetonitrile Induces Oxidative Stress and Apoptosis in Mouse Fetal Brain. Brain Res. Dev. Brain Res. 159:1-11; 2005.
- Paessler S., Aguilar P., Anishchenko M., Wang H.Q., Aronson J., Campbell G.A., Cararra A.S., Weaver S.C. The hamster as an animal model for eastern equine encephalitis--and its use in studies of virus entrance into the brain. J Infect Dis189:2072-2076, 2004
- Granwehr B.P., Lillibridge K.M., Higgs S., Mason P.W., Aronson J.F., Campbell G.A., Barrett A.D.T. West Nile virus: where are we now? Lancet Infect. Dis. 4:547-556, 2004.
- Matalon, R., Surendran, S., Rady, P.L., Quast, M.J., Campbell, G.A., Matalon, K.M., Tyring, S.K., Peden, C.S., Wei, J., Ezell, E.L., Muzyczka, N., Mandel, R.J. Adeno-associated virus-mediated aspartoacylase gene transfer to the brain of knockout mouse for Canavan disease. Mol. Ther., 7:580-7, 2003
- Surendran, S., Rady, P.L., Michals-Matalon, K., Quast, M.J., Rassin, D.K., Campbell, G.A., Ezell, E.L., Wei, J., Tyring, S.K., Szucs, S., Matalon, R. Expression of glutamate transporter, GABRA6, serine proteinase inhibitor 2 and low levels of glutamate and GABA in the brain of knock-out mouse for Canavan disease. Brain Res. Bull. 61:427-435, 2003
- Molina, C.P., Chaljub, G., Campbell, G.A. Pathologic quiz case: A 37-year-old man with spinal cord compression. Arch. Pathol. Lab. Med.., 127:827-829, 2003
- Surendran S, Campbell GA, Tyring SK, Matalon K, McDonald JD, Matalon R. High levels of orexin A in the brain of the mouse model for phenylketonuria: possible role of orexin A in hyperactivity seen in children with PKU. Neurochem. Res.28:1891-1894, 2003
- Peng, B.H., Lee, J.C., Campbell, G.A. In vitro protein complex formation with cytoskeleton anchoring domain of occludin identified by limited proteolysis. J. Biol. Chem. 278:49644-51, 2003
- Raja, V., Campbell, G.A. Unusual Cases Involving the CNS and Nasal Sinuses: CASE 2. Sinonasal Undifferentiated Carcinoma. J. Clin. Oncol., 21:3877-3880, 2003
- Mansour, A.M., Saad, A.J., Haque, A.K., Campbell, G.A., Frangieh, G.T. Ocular pathology in acquired immunodeficiency syndrome. Comp. Ther. 28:155-159, 2002