M. Firoze Khan, Ph.D.

M. Firoze Khan, Ph.D.

Professor and Vice Chair for Research, Department of Pathology;
Member, NIEHS Center;
Member, Sealy Center for Environmental Health & Medicine

University of Texas Medical Branch
301 University Boulevard
Galveston, TX 77555-0438

Office: (409) 772-6881
Fax: (409) 747-1763
mfkhan@utmb.edu

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M. Firoze Khan, Ph.D.

Professional Education

Degree Institution Field of Study Graduation Year
B.S. Aligarh Muslim University, Aligarh, India Chemistry, Zoology, Botany 1976
M.S. Aligarh Muslim University, Aligarh, India Biochemistry 1978
M.Phil. Aligarh Muslim University, Aligarh, India Biochemistry 1980
Ph.D. Aligarh Muslim University, Aligarh, India Biochemistry 1983

Honors

2007 “Researcher of the Year”, Department of Pathology, UTMB, Galveston, TX
2006 Chairperson of a session on “Biomarkers”, 45th Annual Meeting of Society of Toxicology, San Diego, CA
1998 Young Scientist Award, Association of Scientists of Indian Origin in America, San Francisco, CA
1996 Chairperson of a session on “Hematopoietic System”, 35th Annual Meeting of Society of Toxicology, Anaheim, CA

Professional Affiliations

2003-Present Society for Free Radical Biology and Medicine (SFRBM)
1997-2009 American Chemical Society (ACS)
1997-2007 Society for Experimental Biology and Medicine (SEBM
1996-2006 American Association for the Advancement of Science
1996-Present

American Society for Pharmacology and Experimental Therapeutics (Elected)

1994-Present Society of Toxicology (Elected)
1993-Present International Society for the Study of Xenobiotics (ISSX)

Research Interests

  • Oxidative stress and autoimmune diseases
  • Molecular mechanisms of splenic toxicity of aromatic amines
  • Chemical-induced autoimmunity
  • Biomarkers of chemical exposure

Selected Publications

  1. Khan MF, Gallagher JE, Brody AR. Effect of alveolar lining layer proteins and lipids on particle binding and phagocytosis. Toxicol In Vitro 4:93-101, 1990.
  2. Lemaire I, Jones S, Khan MF. Bombesin-like peptides in alveolar macrophage -increased release in pulmonary inflammation and fibrosis. Neuropeptides 20:63-72, 1991.
  3. Khan MF, Gupta GSD. Cellular and biochemical indices of bronchoalveolar lavage for the detection of lung injury following insult by airborne toxicants. Toxicol Lett 58:239-255, 1991.
  4. Khan MF, Boor PJ, Kaphalia BS, Alcock NW, Ansari GAS. Hematopoietic toxicity of linoleic acid anilide: Importance of aniline. Fundam Appl Toxicol 25:224-232, 1995.
  5. Khan MF, Srivastava SK, Singhal SS, Chaubey M, Awasthi S, Petersen DRR, Ansari GAS, Awasthi YC. Iron induced lipid peroxidation in rat liver is accompanied with preferential induction of glutathione S-transferase 8-8 isozyme. Toxicol Appl Pharmacol 131:63-72, 1995.
  6. Khan MF, Kaphalia BS, Prabhakar BS, Kanz MF, Ansari GAS. Trichloroethene-induced autoimmune response in female MRL+/+ mice. Toxicol Appl Pharmacol 134:155-160, 1995.
  7. Khan MF, Gu, Y, Alcock NW, Boor PJ, Ansari GAS. Oxidative stress in splenotoxicity of aniline. Fundam Appl Toxicol 35:22-30, 1997.
  8. Khan MF, Green, SM, Ansari GAS, Boor PJ. Phenylhydroxylamine: Role in aniline-associated splenic oxidative stress and induction of subendocardial necrosis in rats. Toxicol Sci 42:64-71, 1998.
  9. Khan MF, Wu X, Boor PJ, Ansari GAS. Oxidative modification of proteins and lipids in aniline-induced splenic toxicity. Toxicol Sci 48:134-140, 1999.
  10. Khan MF, Wu X, Ansari GAS. Anti-malondialdehyde antibodies in MR +/+ mice treated with trichloroethene and dichloroacetyl chloride:Possible role of lipid peroxidation in autoimmunity. Toxicol Appl Pharmacol 170:88-92, 2001.
  11. Khan MF, Wu, X, Tipnis UR, Ansari GAS, Boor PJ. Protein adducts of malondialdehyde and 4-hydroxynonenal in the livers of iron-loaded rats: Quantitation and localization. Toxicology 173:193-201, 2002.
  12. Khan MF, Wu X, Wang J. Up-regulation of transforming growth factor-beta 1 in splenic toxicity of aniline. Toxicol Appl Pharmacol 187:22-28, 2003.
  13. Khan MF, Wu X, Boor PJ, Ansari GAS. Nitrotyrosine formation in splenic toxicity of aniline. Toxicology 194:95-102, 2003.
  14. Wang J, Kannan S, Li H, Khan MF. Cytokine gene expression and activation of NF-κB in aniline-induced splenic toxicity. Toxicol Appl Pharmacol 203:36-44, 2005.
  15. Khan MF, Kannan S, Wang J. Activation of transcription factor AP-1 and mitogen-activated protein kinases in aniline-induced splenic toxicity. Toxicol Appl Pharmacol 210:86-93, 2006.
  16. Wang G, Cai P, Ansari GAS, Khan MF. Oxidative and nitrosative stress in trichloroethene-mediated autoimmune response. Toxicology 229:186-193, 2007.
  17. Wang G, Konig R, Ansari GAS, Khan MF. Lipid peroxidation-derived aldehyde-protein adducts contribute to trichloroethene-mediated autoimmunity via CD4+Tcell activation. Free Radic Biol Med 44:1475-1482, 2008.
  18. Wang J, Wang G, Ansari GAS, Khan MF. Activation of oxidative stress-responsive signaling pathways in early splenotoxic response of aniline. Toxicol Appl Pharmacol 230:227-234, 2008.
  19. Ma H, Wang J, Abdel-Rahman SZ, Boor PJ, Khan MF. Oxidative DNA damage and its repair in rat spleen following subchronic aniline exposure. Toxicol Appl Pharmacol 233:247-253, 2008.
  20. Wang G, Ma H, Wang J, Khan MF. Nitration and carbonylation of proteins in MRL+/+ mice exposed to trichloroethene: Possible role of protein oxidation in autoimmunity. Toxicol Appl Pharmacol 237:188-195, 2009.

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