Gangduo Wang, M.D., Ph.D.

Gangduo Wang, M.D., Ph.D.

Instructor, Environmental Toxicology, Department of Pathology

University of Texas Medical Branch
2.308 Mary Moody Northen Pavilion
301 University Boulevard
Galveston, TX 77555-0438

Office: (409) 747-0090
gawang@utmb.edu

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Gangduo Wang, M.D., Ph.D.

Professional Education

Degree Institution Field of Study Graduation Year
M.D. Shandong Medical University, Jinan, China Medicine  
Ph.D. Chinese Academy of Preventive Medicine, Beijing, China    

Professional Affiliations

  • Department of Pathology, University of Texas Medical Branch, Galveston, Texas

Research Interests

Experimental models and mechanisms of chemical-induced autoimmunity.

Selected Publications

  1. Wang G, Pierangeli S, Papalardo E, Ansari GAS, Khan MF. Markers of Oxidative and Nitrosative Stress in Systemic Lupus Erythematosus: Correlation with Disease Activity. Arthritis Rheum (submitted) 2009.
  2. Wang G, Reed E, Cuff CF, and Li QQ. An evaluation of ß-elemene in combination with cisplatin as a regimen for prostate cancer chemotherapy. Oncol Rep (submitted) 2009.
  3. Wang G, Wang J, Ma H, Ansari GA, Khan MF.Increased Nitration and Carbonylation of Proteins in Trichloroethene-Mediated Autoimmune Response. Toxicol Appl Pharmacol. 237:188-195, 2009.
  4. Li QQ, Wang G, Zhang M, Cuff CF, Huang L, Reed E. beta-Elemene, a novel plant-derived antineoplastic agent, increases cisplatin chemosensitivity of lung tumor cells by triggering apoptosis. Oncol Rep. 22: 161-170, 2009.
  5. Wang G, König R, Ansari GA, Khan MF. Lipid peroxidation-derived aldehyde-protein adducts contribute to trichloroethene-mediated autoimmunity via activation of CD4 (+) T cells. Free Radic Biol Med. 44:1475-1482, 2008
  6. Wang J, Wang G, Ansari GA, Khan MF. Activation of oxidative stress-responsive signaling pathways in early splenotoxic response of aniline. Toxicol Appl Pharmacol. 230: 227-234, 2008
  7. Wang G, Ansari GA, Khan MF. Involvement of lipid peroxidation-derived aldehyde-protein adducts in autoimmunity mediated by trichloroethene. J Toxicol Environ Health A. 70:1977-1985, 2007.
  8. Wang G, Cai P, Ansari GA, Khan MF. Oxidative and nitrosative stress in trichloroethene-mediated autoimmune response. Toxicology. 229:186-193, 2007.
  9. Yin XJ, Wang G, Khan-Dawood FS. Requirements of phosphatidylinositol-3 kinase and mammalian target of rapamycin for estrogen-induced proliferation in uterine leiomyoma- and myometrium-derived cell lines. Am J Obstet Gynecol. 196:176.e1-5, 2007.
  10. Zhao J, Li QQ, Wang G, Li X, Kim JE, Cuff CF, Huang L, Reed E, Gardner K. In vitro combination characterization of the new anticancer plant drug beta-elemene with taxanes against human lung carcinoma. Int J Oncol. 31:241-252, 2007.
  11. Wang G, Li X, Huang F, Zhao J, Ding H, Cunningham C, Coad J, Reed E and Li QQ. Antitumor Effect of ß-Elemene in Non Small Cell Lung Cancer Cells is Mediated via Induction of Cell Cycle Arrest and Apoptotic Cell Death. Cell Mol Life Sci. 62:881-93, 2005
  12. Li X, Wang G, Zhao J, Ding H, Cunningham C, Coad J, Reed E and Li QQ. Antiproliferative effect of ß-elemene in chemoresistant ovarian carcinoma cells is mediated through arresting the cell cycle at G2-M phase. Cell Mol Life Sci. 62: 894-904, 2005
  13. Li L, Luan Y, Li X, Tang B, Li D, Zhao J, Wang G, Ding H, Reed E, Li QQ. Demonstration of differential gene expression between sensitive and resistant ovarian tumor cells by fluorescence differential display-PCR analysis. Oncol Rep. 13: 793-799, 2005
  14. Hu J, Liu S, Wang J, Xia X, Feng Y, Tao D, Wang G, Li X, Zhao J, Ding H, Reed E, Li QQ, Gong J. Overexpression of the N-terminal end of the p55gamma regulatory subunit of phosphatidylinositol 3-kinase blocks cell cycle progression in gastric carcinoma cells. Int J Oncol. 26: 1321-1327, 2005
  15. Wang G, Reed E, Li QQ. Molecular basis of cellular response to cisplatin chemotherapy in non-small cell lung cancer. Oncol Rep. 12: 955-965, 2004
  16. Wang G, Reed E, Li QQ. Apoptosis in prostate cancer: Progressive and therapeutic implications. Int J Mol Med. 14: 23-34, 2004
  17. Han S, Zhang X, Wang G, Guan H, Garcia G, Li P, Feng L, Zheng B. FTY720 Suppresses Humoral Immunity by Inhibiting Germinal Center Reaction. Blood; 104: 4129-4133, 2004
  18. Hu G, Ryan S, Zhu Y, Reed E, Li X, Wang G, and Li QQ. Vascular endothelial growth factor modulates cisplatin sensitivity in human ovarian carcinoma cells. Cancer The. 1: 31-37, 2004
  19. Zhong X, Li X, Wang G, Zhu Y, Hu G,Zhao J, Ding H, Reed E, Li QQ.Mechanisms Underlying the Synergistic Effect of SU5416 and Cisplatin on Cytotoxicity in Human Ovarian Tumor Cells. Int J Oncol. 25: 445-451, 2004
  20. Li L, Luan Y, Wang G, Li D, Zhang W, Tang B, Reed E, Li QQ. Development and characterization of five cell models for chemoresistance studies of human ovarian carcinoma. Int J Mol Med. 14: 257-264, 2004