D. Mark Estes, Ph.D.
Professor and Senior Scientist,
Department of Pediatrics and Microbiology &Immunology
Sealy Center for Vaccine Development
Center for Biodefense and Emerging Infectious Diseases
School of Medicine
University of Texas Medical Branch
6.200T Galveston National Laboratory
301 University Boulevard
Galveston, TX 77555-0610
Office: (409) 266-6523
Fax: (409) 266-6810
dmestes@utmb.edu
|
Professional Education
| Degree |
Institution |
Field of Study |
Graduation Year |
| B.S. |
Texas Tech University, Lubbock, TX |
Microbiology |
1982 |
| Ph.D. |
Texas A&M University, College Station, TX |
Genetics |
1988 |
| Post-Doctoral Fellow / Instructor |
University of Texas Health Sciences Center at San Antonio, San Antonio, TX |
Immunology |
1992 |
Honors
| 1981 |
E.C. McFadden Academic Scholarship, Texas Tech University |
| 1981 |
National Dean's List, Texas Tech University |
| 1991 |
National Institutes of Health-National Research Service Award, University of Texas Health Sciences Center at San Antonio, Division of Medicine, Rheumatology/Immunology Section |
| 1996 |
Pfizer Award for Research Excellence, University of Missouri College of Veterinary Medicine |
| 1997 |
Visiting scientist, Institute for Animal Health, Compton, Newbury, UK |
| 1998 |
Visiting scientist-United States Agency for International Development (USAID), International Livestock Research Institute (ILRI), Nairobi, Kenya |
| 2000 |
Phi Zeta (honorary) |
| 2005 |
Certified in Good Laboratory Practices (GLP) |
| 2005 |
Certified in Assay Validation under Good Laboratory Practices |
| 2005 |
Completed GLP training for Principal Investigators and Study Directors |
| 2008–Present |
Advisory Board member, Center for Silver Therapeutics, University of Akron |
| 2009 |
Association of Veterinary Immunologists, Distinguished Veterinary Immunologist |
Professional Affiliations
- American Association for the Advancement of Science
- American Association of Immunologists
- American Association of Veterinary Immunologists
- Conference of Research Workers for Animal Diseases
- American Society for Microbiology
- International Society for Vaccines
Research Interests
Our laboratory focuses on immunoregulatory mechanisms in infection and cancer. These interests are relatively broadly defined in several model systems in man and animals. Our long term goals are to develop improved immunotherapeutics and vaccines.
We are currently pursuing several projects in various species. The first project is an extension into humans of previous work done in a ruminant model system via funding through the NIH. We are evaluating a soluble factor derived from dendritic cells which plays a key role in promoting IgA responses by B cells. Several applications are possible to vaccine development and targeting in addition to selective immunodeficiencies.
A second area is to investigate the role of sex steroid hormones and naturally occurring analogues on the innate and adaptive immune response to infection, allergy/asthma, vaccination and cancer. Portions of this project are funded by the Department of Defense and the Sealy Foundation. Our studies have shown differential effects on antigen presenting cells versus CD4+ T cells by estradiol. Specific aspects of signaling are being investigated in ER-deficient mice at the molecular and cellular levels.
A third project is to investigate various vaccination schemes to improve memory and effector responses by CD8+ T cells to subunit vaccination for tuberculosis in addition to better prognostic markers for vaccine efficacy. This project involves multiple collaborations throughout the world in TB endemic areas.
An additional area of interest are in the use of high throughput protective antigen discovery methods such as expression library immunization (ELI) in collaboration with investigators at Arizona State University for use in vaccines to protect against potential threat agents. Genome based approaches are currently in use for a model bacterial pathogen.
Finally, we are collaborating with multiple investigators on campus to develop and characterize animal model systems for evaluation of flavirus and alpha virus infections and vaccination.
Selected Publications
- Signal regulatory protein alpha (SIRPalpha) cells in the adaptive response to ESAT-6/CFP-10 protein of tuberculous mycobacteria. Waters WR, Palmer MV, Nonnecke BJ, Thacker TC, Estes DM, Larsen MH, Jacobs WR Jr, Andersen P, McNair J, F C Minion, Lyashchenko KP, Hewinson RG, Vordermeier HM, Sacco RE. PLoS One. 2009 Jul 29;4(7):e6414. PMID: 19641628 [PubMed - in process]
- Comparative Antimicrobial Activity of Granulysin against Bacterial Biothreat Agents. Endsley JJ, Torres AG, Gonzales CM, Kosykh VG, Motin VL, Peterson JW, Estes DM, Klimpel GR. Open Microbiol J. 2009 Jun 5;3:92-6. PMID: 19587798 [PubMed - in process
- ]CD4+ T cells provide protection against acute lethal encephalitis caused by Venezuelan equine encephalitis virus.Yun NE, Peng BH, Bertke AS, Borisevich V, Smith JK, Smith JN, Poussard AL, Salazar M, Judy BM, Zacks MA, Estes DM, Paessler S. Vaccine. 2009 Jun 19;27(30):4064-73. Epub 2009 May 3. PMID: 19446933 [PubMed - indexed for MEDLINE]
- Comparison of the in vitro and in vivo susceptibilities of Burkholderia mallei to Ceftazidime and Levofloxacin. Judy BM, Whitlock GC, Torres AG, Estes DM. BMC Microbiol. 2009 May 9;9:88. PMID: 19426516 [PubMed - indexed for MEDLINE]
- Burkholderia mallei cellular interactions in a respiratory cell model. Whitlock GC, Valbuena GA, Popov VL, Judy BM, Estes DM, Torres AG. J Med Microbiol. 2009 May;58(Pt 5):554-62. PMID: 19369515 [PubMed - indexed for MEDLINE]
- Human IgA-inducing protein from dendritic cells induces IgA production by naive IgD+ B cells. Endsley MA, Njongmeta LM, Shell E, Ryan MW, Indrikovs AJ, Ulualp S, Goldblum RM, Mwangi W, Estes DM. J Immunol. 2009 Feb 15;182(4):1854-9. PMID: 19201837 [PubMed - indexed for MEDLINE]
- Sero-characterization of lipopolysaccharide from Burkholderia thailandensis. Qazi O, Prior JL, Judy BM, Whitlock GC, Kitto GB, Torres AG, Estes DM, Brown KA. Trans R Soc Trop Med Hyg. 2008 Dec;102 Suppl 1:S58-60. PMID: 19121690 [PubMed - in process]
- Construction of a reporter system to study Burkholderia mallei type III secretion and identification of the BopA effector protein function in intracellular survival. Whitlock GC, Estes DM, Young GM, Young B, Torres AG. Trans R Soc Trop Med Hyg. 2008 Dec;102 Suppl 1:S127-33. PMID: 19121674 [PubMed - in process]
- Efficacy and immunogenicity of Mycobacterium bovis DeltaRD1 against aerosol M. bovis infection in neonatal calves. Waters WR, Palmer MV, Nonnecke BJ, Thacker TC, Scherer CF, Estes DM, Hewinson RG, Vordermeier HM, Barnes SW, Federe GC, Walker JR, Glynne RJ, Hsu T, Weinrick B, Biermann K, Larsen MH, Jacobs WR Jr. Vaccine. 2009 Feb 18;27(8):1201-9. Epub 2009 Jan 9. PMID: 19135497 [PubMed - indexed for MEDLINE]
- The calf model of immunity for development of a vaccine against tuberculosis. Endsley JJ, Waters WR, Palmer MV, Nonnecke BJ, Thacker TC, Jacobs WR Jr, Larsen MH, Hogg A, Shell E, McAlauy M, Scherer CF, Coffey T, Howard CJ, Villareal-Ramos B, Estes DM. Vet Immunol Immunopathol. 2009 Mar 15;128(1-3):199-204. Epub 2008 Oct 18. PMID: 19027175 [PubMed - indexed for MEDLINE]
- Host immunity in the protective response to vaccination with heat-killed Burkholderia mallei. Whitlock GC, Lukaszewski RA, Judy BM, Paessler S, Torres AG, Estes DM. BMC Immunol. 2008 Sep 29;9:55. PMID: 18823549 [PubMed - indexed for MEDLINE]
- Glanders: off to the races with Burkholderia mallei. Whitlock GC, Estes DM, Torres AG. FEMS Microbiol Lett. 2007 Dec;277(2):115-22. Review. PMID: 18031330 [PubMed - indexed for MEDLINE]
- Mycobacterium bovis BCG vaccination induces memory CD4+ T cells characterized by effector biomarker expression and anti-mycobacterial activity. Endsley JJ, Hogg A, Shell LJ, McAulay M, Coffey T, Howard C, Capinos Scherer CF, Waters WR, Nonnecke B, Estes DM, Villarreal-Ramos B. Vaccine. 2007 Dec 5;25(50):8384-94. Epub 2007 Oct 23. PMID: 17996992 [PubMed - indexed for MEDLINE]
- Failure of a Mycobacterium tuberculosis DeltaRD1 DeltapanCD double deletion mutant in a neonatal calf aerosol M. bovis challenge model: comparisons to responses elicited by M. bovis bacille Calmette Guerin. Waters WR, Palmer MV, Nonnecke BJ, Thacker TC, Scherer CF, Estes DM, Jacobs WR Jr, Glatman-Freedman A, Larsen MH. Vaccine. 2007 Nov 7;25(45):7832-40. Epub 2007 Sep 4. PMID: 17931755 [PubMed - indexed for MEDLINE]
- Advances in immunology and vaccine discovery report of the United States-European Commission workshop. Gay CG, Richie TL, Pastoret PP, Minguez-Tudela I, de Baetselier P, Göbel T, Goddeeris B, Kaiser P, Morrison I, Sánchez-Vizcaíno JM, Anderson K, Baillie LW, Brown WC, Estes DM, Herrera E, Nara PL, Ockenhouse CF, Roth JA, Sztein MB. Vaccine. 2007 Oct 10;25(41):7007-11. Epub 2007 Aug 6. PMID: 17728022 [PubMed - indexed for MEDLINE]
- Alpha-beta T cells provide protection against lethal encephalitis in the murine model of VEEV infection. Paessler S, Yun NE, Judy BM, Dziuba N, Zacks MA, Grund AH, Frolov I, Campbell GA, Weaver SC, Estes DM. Virology. 2007 Oct 25;367(2):307-23. Epub 2007 Jul 5. PMID: 17610927 [PubMed - indexed for MEDLINE]
- Early production of type I interferon during West Nile virus infection: role for lymphoid tissues in IRF3-independent interferon production. Bourne N, Scholle F, Silva MC, Rossi SL, Dewsbury N, Judy B, De Aguiar JB, Leon MA, Estes DM, Fayzulin R, Mason PW. J Virol. 2007 Sep;81(17):9100-8. Epub 2007 Jun 13. PMID: 17567689 [PubMed - indexed for MEDLINE]
- Vesicular stomatitis New Jersey virus (VSNJV) infects keratinocytes and is restricted to lesion sites and local lymph nodes in the bovine, a natural host. Scherer CF, O'Donnell V, Golde WT, Gregg D, Estes DM, Rodriguez LL. Vet Res. 2007 May-Jun;38(3):375-90. Epub 2007 Mar 13. PMID: 17506968 [PubMed - indexed for MEDLINE]
- An ESAT-6:CFP10 DNA vaccine administered in conjunction with Mycobacterium bovis BCG confers protection to cattle challenged with virulent M. bovis. Maue AC, Waters WR, Palmer MV, Nonnecke BJ, Minion FC, Brown WC, Norimine J, Foote MR, Scherer CF, Estes DM. Vaccine. 2007 Jun 11;25(24):4735-46. Epub 2007 Apr 24. PMID: 17499400 [PubMed - indexed for MEDLINE]
- Environmental estrogens induce mast cell degranulation and enhance IgE-mediated release of allergic mediators. Narita S, Goldblum RM, Watson CS, Brooks EG, Estes DM, Curran EM, Midoro-Horiuti T. Environ Health Perspect. 2007 Jan;115(1):48-52.
NIH Biosketch
|
