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Dr. Herzog

Norbert K. Herzog, Ph.D.

Professor, Assistant Dean, GSBS,
Department of Pathology

University of Texas Medical Branch
301 University Blvd.
Galveston, TX 77555-0609

Office: (409) 772-3938
Fax: (409) 747-2437
nherzog@utmb.edu

Appointments

2009–Present Professor Departments of Pathology and Microbiology and Immunology, the University of Texas Medical Branch, Galveston, TX
2006–Present Assistant Dean for Recruitment Graduate School of Biomedical Sciences, the University of Texas Medical Branch, Galveston, TX
2006–Present Training Faculty Member Keck Center of the Gulf Coast Consortia Training Program in Nanobiology, Gulf Coast Consortia, Rice University, Houston, TX
2003–Present Member Faculty Center for Biodefense and Emerging Infectious Diseases, the University of Texas Medical Branch, Galveston, TX
2004–Present Member Faculty Institute for Human Infection and Immunity, the University of Texas Medical Branch, Galveston, TX
2004–Present Member Faculty Center for Addiction Research, the University of Texas Medical Branch, Galveston, TX
1994–Present Member Faculty WHO Collaborating Center for Tropical Diseases, the University of Texas Medical Branch, Galveston, TX
1989–Present Member Graduate School of Biomedical Sciences, the University of Texas Medical Branch, Galveston, TX

Professional Education

Degree Institution Field of Study Graduation Year
B.A. University of California at Los Angeles, Los Angeles, CA Bacteriology 1976
M.S. California State University Northridge, Northridge, CA Biology 1979
Ph.D. The University of Texas at Austin, Austin, TX Microbiology 1985

Honors

2009 Medical Discovery News awarded the 2009 Public Health Award for Media Excellence (PHAME)—The Texas Public Health Association
2009 Medical Discovery News awarded the 2009 Award of Excellence—AAMC Group on Institutional Advancement
2008 Graduate Student Organization Faculty Award for Student Advocacy
2008 Graduate Student Organization Distinguished Teaching Award—Graduate School of Biomedical Sciences, the University of Texas Medical Branch, Galveston, TX
2005–2006 Paul Brindley Distinguished Scholar Award
2004 Nominee for the 2004 Graduate Student Organization Teaching Award
2002 Nominee for the 2002 Graduate Student Organization Faculty Award for Student Advocacy
2001 The Leon Bromberg, M.D. Professorship for Excellence in Teaching of the Graduate School of Biomedical Sciences in honor of Truman Blocker, M.D.

Professional Affiliations

  • American Society of Virology (Member of the Public Affairs Committee)
  • American Society for Microbiology
  • American Society for Microbiology—Texas Branch
  • American Association for the Advancement of Science
  • Alliance for NanoHealth
  • Sigma Xi*—Nominated
  • Texas Society for Biomedical Research
  • Texas Association of Advisors for the Health Professions
  • Phi Kappa Phi*—Treasurer (2006–Present)

Research Interests

My research focuses on the mechanisms of cellular signal transduction in disease pathogenesis in particular the pathogenesis of arenaviruses.  Signal transduction has become an integral part of the mechanistic studies into disease pathogenesis including those caused by bacteria and viruses. Though we know a great deal about cellular signal transduction, we are still far from understanding this extraordinarily complex process. Dysregulation of the host response frequently results in pathologies associated with infections.  There are specific qualitative and quantitative changes in a variety of cellular signaling pathways in cultured macrophages and in macrophages derived from animal infected by virulent Pichinde virus (a model for human Lassa Fever) but not with the attenuated virus. We are involved in defining the genomic, proteomic and kinomic changes in cells in response to virulent and attenuated arenaviruses. We (in collaboration with Dr. Aronson) are in the process of defining the viral mechanisms that induce these changes in host cell signaling and their influence on pathogenesis of these arenaviruses. We are examining the role individual and combinations of arenaviral proteins in modulating cell signaling.  We are performing similar studies of West Nile virus infections.

In collaboration with our colleagues (Drs. Aronson, Gorenstein, Luxon) we are developing decoy oligonucleotides that act as decoys to modulte the antivities of transcription factors (i.e. NF-kB/Rel, AP-1) and modulate the expression of proinflammatory cytokines in response to Pichinde virus and West Nile virus infection and in an animal model of sepsis in an effort to reduce pathogenesis and to more precisely define which genes each dimer regulates.  We hope to generate novel anti-viral compounds to treat viral infections such as those which cause fatal hemorrhagic fevers.  We are also developing a novel proteomics chips to monitor changes in the host proteome in response to viral infections.

Selected Publications

  1. Lin, J, Tao, J, Dyer, Roy B, Herzog, NK, Justement, LB.  Kinase-independent potentiation of B cell antigen receptor-mediated signal transduction by the protein tyrosine kinase. J Allergy Clin  Immun 99: 882-882 1997.
  2. Dyer, Roy B, Herzog, NK.  Differential regulation of NFkB/Rel protein activities during LPS-induced 70Z/3 cell differentiation. In Vitro 23:231-238 1998
  3. Dyer, Rex B, Herzog, NK.  Utilization of Tris/Tricine polyacrylamide gels in the analysis of peptide/DNA interactions.  Biotechniques.25:447-449 1998.
  4. Yang, X.-B, Fennewald, S Luxon, BA, Aronson, J, Herzog, NK, Gorenstein, DG.  Aptamers containing thymidine 3’-O-phosphorothioates:  Synthesis and binding to Nuclear factor-kB. Bioorganic Medicinal Chemistry Letters: 9:3357-3362  1999. Times Cited (12)
  5. Kain, K.H., Popov, S., Herzog, NK  A role for the mitochondrial transcription factor in regulating respiratory capacity during differentiation Biochimica Biophysica Acta 1494(1-2):91-103 2000. Times Cited (5)
  6. Fennewald, SM, Aronson, JF Zhang L, Herzog, NK Alterations in NFkB and RBP-Jk by Arenavirus Infection of Macrophages in vitro and in vivo. J. Virol. 76(3):1154-1162 2002. Times Cited (14)
  7. King, DJ, Basset, SE, Herzog, NK, Shope, RS, Fennewald, SA, Luxon, BA, Gorenstein, DG.  Combinatorial selection and binding of phosphorothioate aptamers targeting human NF-kB RelA(p65) and p50 Biochemistry 41:9696-9706  2002. Times Cited (21)
  8. Volk DE, Yang, X,. Fennewald, SM, King, DJ, Bassett, SE, Venkitachalam, S, Herzog NK, Luxon, BA and Gorenstein, DG. Solution structure and design of dithiophosphate backbone aptamers targeting transcription factor NF-kB. Bioorganic Chemistry 30 396-419 2002.  Times Cited (2)
  9. Yang,X, Bassett,S,  Li, X, Luxon, BA, Herzog, NK, Shope, RE, Aronson, J, Prow, TW, Leary, JF, Romy, K, Ellington, A, Gorenstein, DG Construction and Selection of bead-bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries designed for rapid PCR-based sequencing.  Nucleic Acids Research 30(23):e132 2002. Times Cited (8)
  10. Yang,X,  Li, X, Prow TW, Reese, LM, Bassett S, Luxon, BA, Herzog, NK, Aronson, J, Shope, RE, Leary, JF, Gorenstein, DG Immunofluorescence assay and flow cytometry selection of bead bound aptamers. Nucleic Acids Research 31(10): 1-8 2003.
  11. Bassett, SE, Fennewald, SM, King, DJ, Li, X, Herzog, NK, Shope, RE, Aronson, JF, Luxon, BA, Gorenstein, DG.  Combinatorial selection and edited combinatorial selection of phosphorothioate aptamers targeting human NF-kB RelA/p50 and RelA/RelA.  Biochemistry 43(28): 9105-9115, 2004. Times Cited (11)
  12. Wang, H, Yang, X, Bowick, GC,  Herzog, NK, Luxon, BA,. Lomas, LO, Gorenstein, DG.  Identification of proteins bound to a thioaptamer probe on a proteomics array.  BBRC 347:586-593, 2006. Times Cited (6)
  13. Bowick, GC, Fennewald, SM, Scott, EP, Zhang, L, Elsom, BL, Aronson, JF, Spratt, HM, Gorenstein, DG, Herzog, NK. Differentially activated cell signaling networks following haemorrhagic fever infections. J. Virology 80(20):10248 – 10252, 2006. Times Cited (9).
  14. Yang, X, Wang, HE, Beasley DWC, Volk, DE, Zhao, X, Luxon, BA,  Lomas, LO,  Herzog, NK, Aronson, JF, Barrett, ADT, Leary, JF, Gorenstein, DG. Selection of Thioaptamers for Diagnostics and Therapeutics.  NY Acad Sci, 1082, 116-119, 2006.
  15. Tacker, DH, Herzog, NK, Okorodudu, AO. Cocaethylene activation of p38 Mitogen-activated protein kinase and nuclear factor kappa-B DNA binding.  (Clinical Chemistry 52(10),1926-1933, 2006).
  16. Fennewald, SM, Webb, ES, Zhang, L, Yang, XB, Aronson, JF, Gorenstein, DG, Luxon, BE,  Shope,RE, Herzog, NK.  Thioaptamer Decoys Targeting AP-1 Proteins Influence Cytokine Expression and the Outcome of Arenavirus Infections. J. General Virology 88:  981-990, 2007. Times Cited (4)
  17. Bowick, GC, Fennewald, SM, Scott, EP, Zhang, L, Elsom, BL, Aronson, JF, Spratt, HM, Luxon, BA, Gorenstein, DG, Herzog, NK. Identification of differentially activated cell signaling networks associated with hemorrhagic fever virus pathogenesis using systems kinomics Journal of Virology 81(4): 1592-1600, 2007. Featured on the JV Spotlight Page as an “Article of Significant Interest From This Issue by the Editors”. Times Cited (7)
  18. Vela EM, Bowick G, Herzog, N, Aronson JF. 2008. Genistein treatment of cells inhibits arenavirus infection. Antiviral Research 77(2): 153-156. Times Cited (2)
  19. Bowick, GC, Spratt, HM, Wiktorowicz, JM, Kurosky, A, Luxon, BA, Gorenstein, DG, Herzog, NK. 2009  Analysis of the Differential Host-Cell Nuclear Proteome Induced by Attenuated and Virulent Hemorrhagic Arenavirus Infection. J. Virology, 83(2): 687-700 Times Cited (0)
  20. Hogg, A, Bowick, G, Herzog,NK, Cloyd, MW, Endsley, J.  Induction of granulysin in CD8+ T cells by IL-21 and IL-15 is suppressed by human immunodeficiency virus-1" by (In Press,  J. of Leukocyte Biology, 2009)

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